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Efficient panax notoginseng saponins injection and preparation method thereof

A technology of Panax notoginseng saponins and glycoside injections, applied in the field of pharmaceutical inventions, can solve problems such as differences in components and different production processes, and achieve the effects of strong LDH content, good effect, and improvement of nerve function

Inactive Publication Date: 2012-02-01
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The existing Panax notoginseng saponins are extracted from the raw materials of Panax notoginseng, and the composition ratio of each saponin in the Panax notoginseng saponins has not been deliberately adjusted. It is the same as the raw material of notoginseng, but the production process of each manufacturer is different, resulting in the composition of each saponin in the total saponins of notoginseng produced by each enterprise. Between -1.3:1

Method used

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  • Efficient panax notoginseng saponins injection and preparation method thereof
  • Efficient panax notoginseng saponins injection and preparation method thereof
  • Efficient panax notoginseng saponins injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Panax notoginseng total saponins freeze-dried powder injection

[0052] 1. Extraction method:

[0053] Take the main root of Panax notoginseng, make 40-mesh coarse powder, extract twice, add 12 times of 60% ethanol each time, extract for 2 hours each time, combine the extracts, filter, take the filtrate to recover the ethanol until it has no alcohol smell, and reduce the pressure Concentrate to contain about 0.5g of crude drug per 1ml, add sodium chloride to make the concentration of sodium chloride reach 0.05%, stir well, let stand, and filter;

[0054] Take the filtrate and add 0.1% sodium citrate, pass through a macroporous adsorption resin column 0.5 times the weight of Panax notoginseng for adsorption, the flow rate is 0.5BV / h; use 1BV, the concentration is 0.1% sodium hydroxide solution to elute, the flow rate is 0.5BV / h, the eluent was discarded; the column was washed with purified water until the effluent was neutral, and the eluent was discarded; t...

Embodiment 2

[0065] Embodiment 2: the extraction method of Panax notoginseng total saponins

[0066] 1. Extraction method:

[0067] Take notoginseng reed head, make 30 mesh coarse powder, extract 5 times, add 8 times of 95% ethanol each time, extract 5 hours each time, combine the extracts, filter, take the filtrate to recover ethanol until there is no alcohol smell, reduce Concentrate under pressure so that every 1ml contains about 1g of crude drug, add sodium chloride to make the concentration of sodium chloride reach 0.5%, stir well, let stand, and filter;

[0068] Take the filtrate and add 1.0% sodium citrate, and pass through a macroporous adsorption resin column 10 times the weight of Panax notoginseng for adsorption at a flow rate of 2.0 BV / h; elute with 0.5 BV and a concentration of 0.1% sodium hydroxide solution at a flow rate of 15 BV / h, the eluent was discarded; the column was washed with purified water until the effluent was neutral, and the eluent was discarded; then the col...

Embodiment 3

[0073] Embodiment 3: the extraction method of Panax notoginseng total saponins

[0074] 1. Extraction method:

[0075] Take the main root of Panax notoginseng, make 20 mesh coarse powder, extract 4 times, add 10 times of 70% ethanol each time, extract for 4 hours each time, combine the extracts, filter, take the filtrate to recover the ethanol until it has no alcohol smell, and reduce the pressure Concentrate to contain about 0.6g of crude drug per 1ml, add sodium chloride to make the concentration of sodium chloride reach 0.2%, stir well, let stand, and filter;

[0076] Take the filtrate and add 1.0% sodium citrate, and pass it through a macroporous adsorption resin column 3 times the weight of Panax notoginseng for adsorption at a flow rate of 1.0BV / h; elute with 3BV and a concentration of 0.1% sodium hydroxide solution at a flow rate of 5BV / h h, discard the eluent; then wash the column with purified water until the effluent is neutral, then discard the eluent; then wash th...

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Abstract

The invention discloses an efficient panax notoginseng saponins injection and a preparation method thereof. The injection comprises active ingredients in percentage by weight: 9.5-15.0% of notoginsenoside R1, 37.0-56.0% of ginsenoside Rg1, 5.0-8.0% of ginsenoside Re, 21.0-32.0% of ginsenoside Rb1 and no less than 0.45% of ginsenoside Rd; and a weight ratio of panaxtriol saponins to panaxadiol saponins is 1.5-3.5:1. By verifying through a pharmacodynamic experiment, the efficient panax notoginseng saponins injection, according with the ratio of the panaxtriol saponins to the panaxadiol saponins in the invention, has good effects in the treatment of cardio-cerebrovascular diseases, such as obstruction of collaterals by blood stasis, apoplectic hemiplegia, chest stuffiness and pains, central retinal vein occlusion and the like.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a highly effective Panax notoginseng saponin injection for treating diseases such as cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Panax notoginseng saponins are a commonly used medicine for the treatment of cardiovascular and cerebrovascular diseases in clinical practice. The injection preparations of Panax notoginseng total saponins currently used for the treatment of cardiovascular and cerebrovascular diseases include: Xueshuantong injection, Xueshuantong for injection, Xuesaitong injection, Xuesaitong for injection. [0003] The following table compares the proportions of the ingredients in Panax notoginseng total saponins injection published by national standards such as "Drug Standards of the Ministry of Health of the People's Republic of China" and "National Standards Compilation of Chinese Proprietary Medicine...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K9/08A61K9/14A61K31/704A61K36/258A61P9/00
Inventor 许淑清黄宇声刘冠萍张栩颜李钊文陈小杰
Owner GUANGXI WUZHOU PHARMA GRP
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