Formula and preparation method of iodine complex solution

Abstract

The invention discloses a formula and a preparation method of an iodine complex solution. The formula comprises the specific components of 1-6 percent of iodine, 1-5 percent of potassium iodide, 20-40 percent of surface active agent, 5-20 percent of glycerol dimethoxymethane, 10-20 percent of glycerol, 0.2-0.4 percent of phosphoric acid and the balance of purified water. Because the surface active agent, the glycerol and the glycerol dimethoxymethane are used in the iodine complex solution, thus the iodine complex solution has the characteristics of strong stability, longer storage period, more thorough sterilization, large dilution factor, small consumption, high content of effective iodine, and the like; and the preparation method is simple and is suitable for industrialized production.

Description

Technical field: [0001] The invention relates to the field of medical disinfectants, in particular to a solution formulation and preparation method of complexed iodine. Background technique: [0002] The bactericidal mechanism of iodine preparations is to change the configuration of microbial cell wall proteins and increase membrane permeability, thereby causing damage to mitochondria, inhibition of respiratory enzymes, energy metabolism disorders, direct oxidation and halogenation of cytoplasmic substances, and destruction of intracellular structures. Impairment of DNA replication and transcription can cause spore swelling, deformation, depression or local damage, and can cause damage to the permeability barrier between the crustin layer and the cortex layer, resulting in the leakage of DPA, DNA, RNA, etc. At the same time, it also causes the activity of glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and alkaline phosphatase in the bacteria to decrease, which aff...

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Problems solved by technology

At the same time, it also causes the activity of glucose-6-phosphate dehydrogenase, lactate dehydrogenase and alkaline phosphatase to decrease in the bacteria, which affects the transmission of genetic information and the synthesis of proteins, resulting in the final death of fungal cells.

[0003] At present, there are many disinfectants with iodine as the main component on the market, such as iodine tincture solution, iodophor, povidone iodine solution, complexed iodine disinfectant, double-chain quaternary ammonium salt complexed iodine solution, etc., which play a major role The most important is the effective I. Since iodine is a relatively active element and is very easy to volatilize, most of these iodine preparations have a short shelf life. At present, the domestically produced iodine preparations have a validity period ranging from 0.5 to 2 years. Generally low, generally 0.1% to 1%, the curative effect is reduced, the quality is unstable, and it cannot meet the demand for multiple uses of iodine preparations

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