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Anticoagulation coating and preparation method and application thereof

An anti-coagulation and coating technology, applied in the direction of coating, can solve the problems of poor treatment effect inside the tube wall, unsuitable for large-area use, poor mechanical properties, etc., to improve anti-coagulation performance, reduce operation time and operation. Difficulty, reducing the effect of interactions

Inactive Publication Date: 2012-01-18
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, MPC monomers and polymers have strong moisture absorption and poor mechanical properties, so their direct application is limited.
[0005] In order to solve the above problems, our research group used the ozone activation method to build MPC on the surface of the material, and achieved a good anticoagulant effect. However, the process is long and the treatment effect on the inside of the tube wall is poor, so it is not suitable for large-scale use.

Method used

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  • Anticoagulation coating and preparation method and application thereof
  • Anticoagulation coating and preparation method and application thereof
  • Anticoagulation coating and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh 1g (0.004mol) γ-(methacryloxy)propyltrimethoxysilane (KH-570, purified by distillation under reduced pressure), 0.0173g (0.1mmol) N,N,N',N ,'N''-pentamethyldiethylenetriamine (PMDETA), 0.03901g (0.2mmol) ethyl 2-bromoisobutyrate (EBiB) dissolved in 2ml ethanol (after anhydrous purification) into solution, under the protection of inert gas, repeated degassing several times to remove oxygen. Add 0.0072g (0.05mmol) CuBr powder under an inert gas protection atmosphere, and pump again for 10min. Then the reaction system was sealed, heated in an oil bath at 60° C., and reacted for 12 hours.

[0039] The reaction solution was rotary evaporated to remove ethanol, dissolved in THF, and the precipitated catalyst was removed by centrifugation. Then the upper layer solution was separated through a neutral alumina chromatography column to obtain a colorless THF solution. Use a rotary evaporator to distill under reduced pressure at 50°C for 10 minutes to remove the EBiB small-...

Embodiment 2

[0043] 1.5 grams of MPC is added to the reaction system, and 2-bromo-2-methylpropionyloxyethanol, pentamethyldiethylenetriamine, CuCl are mixed according to the ratio of M MPC :M 2-溴代异丁基酰氧基乙醇 :M 五甲基二亚乙基三胺 :M CuCl =50:1:0.2:0.1 was added to the reaction system, degassed, and reacted at 30°C for 24 hours. Under an inert gas atmosphere, add KH570, about 0.6 g, half the amount of MPC, and continue to react for 48 hours. With the activated cation exchange resin as the stationary phase and absolute ethanol as the mobile phase, the catalyst is eluted by column chromatography. The resulting final solution was diluted to 100 mL with ethanol, the number average molecular weight of the copolymer was 12200)

[0044] Immediately immerse the polyethylene membrane into the above solution after irradiating it with plasma, add 0.2 g of triethanolamine, shake it well, let it stand for 5 minutes, take it out and cure it at 100°C for 2 hours, rinse it with PBS buffer solution, and obtain antic...

Embodiment 3

[0046] Add 0.5 g of triethanolamine to the solution obtained in Example 1, immerse the cleaned cellulose membrane in the solution, solidify at 120° C. for 1 hour, and rinse to obtain an anticoagulant cellulose membrane with a coating thickness of 200 nanometers.

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Abstract

The invention discloses an anticoagulation coating. An alcohol solution of a segmented copolymer with a regular structure and narrow molecular weight distribution is formed by gradually polymerizing a zwitterionic monomer and gamma-(methacrylic acyloxy) propyltrimethoxysilane (KH-570); the number-average molecular weight of the copolymer is 5,000-50,000; and the zwitterionic monomer can be an ammonium phosphate, ammonium carboxyl or ammonium sulphur zwitterionic monomer which contains methacrylic acyloxy, methacrylic acylamino or cinnamenyl. The anticoagulation macromolecular coating can be effectively bonded on the surface of a material, so that the anticoagulation performance of the material is improved. The invention further discloses a preparation method and a using method of the coating.

Description

technical field [0001] The invention relates to a surface modification coating which can effectively improve the anticoagulant performance of the material surface and a preparation method thereof. Background technique [0002] Various devices in contact with blood have anticoagulation problems. At present, the main method of anticoagulation is to use heparin to coat the surface of the device, but this method is prone to spontaneous bleeding, thrombocytopenia and allergic reactions, hair loss, diarrhea, and osteoporosis. , spontaneous fractures and other adverse reactions, long-term use in patients with poor liver function can cause depletion of antithrombin III and thrombosis tendency; long-term use can cause abnormal blood lipid metabolism; heparin is contraindicated with many drugs, which seriously affects the development of medicine. [0003] In the past, anticoagulant substances such as heparin (Heparin) would dissolve and be used up from the coating, and the surface act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D153/00C09D5/00C09D7/12C08F293/00C08F220/36
Inventor 陈强袁勃丁文全刘莉莉沈健林思聪
Owner NANJING UNIV
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