Device and method for stretching elastic tissue under simulated physiological condition

A stretching device and elastic tissue technology, which is applied in the field of basic medical experiments, can solve the problems of easy detachment of adhesion points, small size, short adhesion points, etc., and achieve the effect of controllable freezing temperature and maintaining physiological activity

Inactive Publication Date: 2011-11-23
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using this device for experiments, the sample needs to be sent into the clamping hole for a long distance and fully frozen to ensure the stability of the clamping, so that the sample cannot be guaranteed to have biological activity.
On the other hand, when doing the tensile test of small-sized ligaments, the test sample size is small and the adhesion point is short, which cannot guarantee stability; when doing the tensile test of larger-sized ligaments, the pulling force is large, and the frozen adhesion points are easy to fall off

Method used

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  • Device and method for stretching elastic tissue under simulated physiological condition
  • Device and method for stretching elastic tissue under simulated physiological condition
  • Device and method for stretching elastic tissue under simulated physiological condition

Examples

Experimental program
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Effect test

Embodiment 1

[0028] An elastic tissue stretching device under simulated physiological conditions, comprising a lower fixture 1 connected to the stretching machine table and equipped with a lower clamp 3 and an upper fixture connected to the rising part of the stretching machine and equipped with an upper clamp 5 part 8, the size of the clamping part of the lower clamping part 3 and the upper clamping part 5 is adjustable, and a water bath cavity containing physiological saline is formed between the sealing sleeve 2 installed on the lower fixing part 1 and the lower clamping part 3 13. The upper fixing part 8 is equipped with a liquid nitrogen container 6 with a piston surrounding the upper clamping part 5, the lower clamping part 3 and the upper clamping part 5 have through holes for elastic tissue to pass through, and the water bath chamber 13 The depth is adjusted by the lower clip 3 and the sealing sleeve 2 which are threadedly connected to the lower fixture 1, and the liquid nitrogen co...

Embodiment 2

[0044] A method for stretching elastic tissue under simulated physiological conditions, comprising the following steps:

[0045] 1). Extracting tissue: extracting elastic tissue with bone at one end as a sample from a freshly dead animal used as an experiment;

[0046] 2). Sample processing: cut off the soft tissue around the elastic tissue, and measure the length, width, and thickness of the elastic tissue;

[0047] 3). Embedding treatment: embedding the end of the sample without bone with tissue freezing embedding agent;

[0048] 4). Assembly device: connect the upper fixing part of the stretching device to the rising part of the stretching machine, and connect the lower fixing part of the stretching device to the bottom fixing part of the stretching machine;

[0049] 5). Simulation of physiological conditions: the lower clamp of the stretching device is installed on the lower fixture, and a water bath chamber containing physiological saline is formed between the sealing s...

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Abstract

The invention aims to overcome the defects in the prior art and provides a device for stretching elastic tissue under a simulated physiological condition. The device comprises a lower fixed piece and an upper fixed piece, wherein the lower fixed piece is connected with the table surface of a stretching machine and is provided with a lower clamping piece; the upper fixed piece is connected with a hoisting piece of the stretching machine and is provided with an upper clamping piece; a water bath cavity for accommodating normal saline is formed between a sealing sleeve arranged on the lower fixed piece and the lower clamping piece; and the upper fixed piece is provided with a liquid nitrogen container which is provided with a piston and surrounds the upper clamping piece. The invention also provides a method for simulating the physiological condition in vitro and stretching the elastic tissue. The method comprises the steps of extracting the tissue, performing embedding processing, loading the samples, simulating the physiological condition, stretching and the like. By the device and the method provided by the invention, the small elastic tissue can be stretched under the simulated physiological condition in vitro.

Description

technical field [0001] The invention relates to basic medical experiments, in particular to provide an experimental device and an experimental method for simulating physiological conditions. Background technique [0002] In vivo research on the physiological properties of elastic tissues such as ligaments or tendons is costly and takes a long time. Therefore, simulating physiological conditions in vitro and studying elastic tissues is an urgent problem to be solved in basic medical experiments. At present, the equipment for in vitro research on elastic tissue is mainly produced by instron and bose. However, the existing equipment can only stretch some larger ligaments and tendon tissues such as the back tendon of cattle. When stretching some small ligaments or tendons, the surface of the tendon or ligament will slip when the clamping force is small, and the clamping When the force is large, the tendon or ligament will be damaged and ruptured, and the experiment cannot be co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N3/08G01N1/28
Inventor 杨力刘二福徐伟彭永金王业全穆罕纳德.哈立德.艾哈迈德吕永钢
Owner CHONGQING UNIV
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