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Preparation method of new material for separating chiral aspartic acid

A technology for aspartic acid and new materials, which is applied in the field of preparation of new materials for splitting chiral aspartic acid, can solve the problems of difficulty in achieving industrial production scale and low efficiency of splitting chiral amino acids, and improve mechanical The effect of intensity

Active Publication Date: 2011-10-26
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that the resolution of chiral amino acid is low and it is difficult to reach the scale of industrial production, and provides a method for preparing a new material for splitting chiral aspartic acid

Method used

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  • Preparation method of new material for separating chiral aspartic acid
  • Preparation method of new material for separating chiral aspartic acid
  • Preparation method of new material for separating chiral aspartic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A preparation method of a new material for splitting chiral aspartic acid, comprising the following steps:

[0043] (1) Chemical surface modification of silica gel: add 10g of activated silica gel to 130ml of water solvent, and add 13ml of coupling agent γ-(methacryloyloxy)propyltrimethoxysilane, react at 50°C for 22h , the product after suction filtration was repeatedly washed with ethanol and dried in vacuum to obtain surface-modified silica gel particles MPS-SiO 2 ;

[0044] (2), chemically grafted polymethacrylic acid on the surface of silica gel particles: add 1.3g of modified silica gel particles MPS-SiO to a four-necked flask 2 , then add 80mL of water and 4.5mL of monomer DMAEMA, pass nitrogen for 30min to remove the air in the system, then raise the temperature of the system to 40°C, add the initiator ammonium persulfate, the amount of ammonium persulfate is the monomer mass 1% of the graft polymerization reaction at 75 ° C for 10 h, suction filtration, to ob...

Embodiment 2

[0047] A preparation method of a new material for splitting chiral aspartic acid, comprising the following steps:

[0048] (1) Surface chemical modification of silica gel: Add 13g of activated silica gel to 150ml of water solvent, and add 10ml of coupling agent trimethoxyallylsilane, react at 50°C for 24h, and the product after suction filtration is washed with ethanol After repeated washing and vacuum drying, the surface-modified silica particles MPS-SiO 2 ;

[0049] (2), chemically grafted polymethacrylic acid on the surface of silica gel particles: add 1.5g of modified silica gel particles MPS-SiO to a four-necked flask 2 , then add 90mL of water and 5mL of monomer DMAEMA, pass nitrogen for 30min to remove the air in the system, then raise the temperature of the system to 40°C, add the initiator ammonium persulfate, the amount of ammonium persulfate added is 1% of the monomer mass 1.1%, carry out graft polymerization at 75°C for 11 hours, and filter with suction to obtain...

Embodiment 3

[0052] A preparation method of a new material for splitting chiral aspartic acid, comprising the following steps:

[0053] (1) Surface chemical modification of silica gel: Add 15g of activated silica gel to 100ml of water solvent, and add 15ml of coupling agent trimethoxyvinylsilane, react at 50°C for 20h, and the product after suction filtration is repeated with ethanol Washed and dried in vacuum to obtain surface-modified silica particles MPS-SiO 2 ;

[0054] (2), chemically grafted polymethacrylic acid on the surface of silica gel particles: add 1g of modified silica gel particles MPS-SiO to a four-necked flask 2 , then add 100mL of water and 4mL of monomer DMAEMA, pass nitrogen for 30min to get rid of the air in the system, then raise the temperature of the system to 40°C, add the initiator ammonium persulfate, the amount of ammonium persulfate added is the weight of the monomer 1.2%, carry out graft polymerization reaction at 75°C for 12h, and filter with suction to obt...

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Abstract

The invention discloses a preparation method of a new material for separating chiral aspartic acid, and solves the problems of difficulty and low efficiency of L-Asp separation currently. The method comprises the following steps of: activation of silica gel particles; chemical bonding of the silica gel particles with a double bond-containing silane coupling agent; chemical grafting of the silica gel particles with polydimethylaminoethyl methacrylate; and preparation of silica gel particle surface molecularly imprinted polymer. The invention adopts silica gel particles as carriers, adopts dimethylaminoethyl methacrylate as a functional macromolecular material grafted on the particles or the particle surfaces, and adopts ether dihalide as a cross-linking agent to prepare the surface imprinted material with high molecular binding speed, strong recognition selectivity, high binding capacity to L-Asp; the surface imprinted material prepared by the invention is suitable for the requirements of industrial production, and has high material utilization rate, low cost, and very good selectivity, recognition and bonding performance to L-Asp molecules.

Description

technical field [0001] The invention relates to a preparation method of a new material for splitting chiral aspartic acid. Background technique [0002] Amino acids are ubiquitous in nature and are the basic unit of protein, and the free amino acids in the living body also play an important role in the metabolism and function regulation of the body. The natural amino acids with biological activity are all L-type, while the amino acids prepared by chemical synthesis are generally DL-type racemates. The physiological functions of these two amino acid enantiomers are quite different, and their biological activities are similar to those in vivo. The chiral environment (enzymes, hormones, receptors, antibodies, etc.) is closely related. [0003] The separation of amino acid enantiomers is of great significance in the research of life sciences. At the same time, with the rapid development of the application of amino acids in the fields of drug synthesis, food and feed industry, a...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08J9/26C08J3/24C07C229/24C07C227/34B01J20/26B01J20/30B01D15/08
Inventor 安富强杜瑞奎高保娇
Owner ZHONGBEI UNIV
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