Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel selenic acid biological material with anti-aging function

A technology of arginine selenate, raw material, applied in the field of food science, can solve the problems of narrow range of selenium therapeutic dose and poisoning dose, high dose, dependence on antioxidant effect, etc.

Inactive Publication Date: 2011-10-19
天津市食品加工工程中心
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the range of therapeutic and toxic doses of selenium is very narrow, and the antioxidant effects of selenium often depend on higher doses

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel selenic acid biological material with anti-aging function
  • Novel selenic acid biological material with anti-aging function
  • Novel selenic acid biological material with anti-aging function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Using arginine selenate as raw material, the pre-column derivatization method was used for HPLC analysis, and it was found that compared with Arg, the polarity of arginine selenate increased, and the peak eluting time in the reversed-phase C18 column was earlier. FTIR detection found: 1047cm was added in the FTIR image -1 and 869cm -1 The characteristic bands of stretching vibration of Se-O and Se=O, and the absorption peaks of other groups are also shifted correspondingly by the influence of the newly introduced groups. NMR analysis and FTIR comprehensive analysis show that arginine selenate is in the C of Arg molecule 2 Introduced -SeO on the primary amine 3- , Fluorescence photometer detection found that the selenium content of the product was 213.7 mg / g, which confirmed that only one Se atom was introduced into Arg, which was consistent with the structure of arginine selenate obtained from structural characterization. Further detection of conventional indicators ...

Embodiment 2

[0031] This experiment replicates the D-gal aging model. The Morris water maze test shows that arginine selenate can delay the decline of learning and memory ability of aging mice to a certain extent. eArg can significantly increase the brain index and brain protein content, and can maintain the balance of the central cholinergic nervous system and protect neurons by reducing the activity of acetylcholinesterase. Arginine selenate can reduce the NO content of mice in the model group, inhibit the neurotoxicity mediated by high concentrations of NO in the brain, and reduce the attack of NO on SOD, thereby protecting brain function. Arginine selenate can significantly increase Na + -K + -ATPase and Ca 2+ -ATPase activity, improve brain energy metabolism, regulate cell transport function, improve the functional state of neuron plasma membrane, alleviate a series of pathophysiological reactions induced by the decrease of ATPase activity, and delay the aging of brain tissue. The...

Embodiment 3

[0033] This experiment replicates the D-gal aging model. Liver pathological examination proved that D-gal can cause damage to the liver morphology and structure of mice, and arginine selenate has obvious inhibitory effect on the morphological changes of liver cells, steatosis and liver fibrosis induced by D-gal. Serum enzymatic test results show that arginine selenate has a certain protective effect on the stability of liver cell membrane structure, can reduce the degree of liver damage, and effectively inhibit the increase of serum ALT, AST, AKP caused by liver damage , and the effect of low concentration is better than that of high concentration. The analysis of liver fatty acid composition showed that arginine selenate can effectively maintain the content of unsaturated fatty acids oleic acid, linoleic acid and linolenic acid in the liver, which plays an important role in maintaining the normal shape and function of cell membranes. The results of oxidative stress detection...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel selenic acid biological material with an anti-aging function, which is prepared by the following steps: taking arginine and SeO2 as raw materials, leading selenic acid-perssad into the arginine by utilizing a chemical synthesis method, and preparing a new organic selenium source. The selenic acid has an obvious anti-aging function, and is low-toxic and efficient, thus being served as a new supplemental se preparation to be used in the fields such as medicament, health-care products, cosmetics and the like.

Description

technical field [0001] The invention belongs to the field of food science and technology. In particular, it relates to the preparation of a novel arginine selenate and the verification of its anti-aging function. Background technique [0002] Aging or aging is an inevitable stage in the body's metabolic process. The mechanism of aging is quite complicated, involving changes in the structure and function of various systems in the body. Anti-aging and life extension has always been the subject of research in the scientific community. According to the calculation of modern biology, the life expectancy of a person is 8 to 10 times that of sexual maturity (ie 100 to 150 years). With the natural aging of the human body, the body's ability to adapt to environmental stimuli is reduced or lost, various tissue functions gradually decline, people's cognitive behaviors appear various obstacles, Parkinson's disease, Alzheimer's disease and multiple sclerosis, etc. The incidence of neu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C391/00A61K31/185A23L1/29A61K8/58A61P3/02A61P25/00A61P39/06A61P37/04A61P1/16A23L33/00
Inventor 刘安军王维君郑捷张春霞刘东岳
Owner 天津市食品加工工程中心
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com