Bufo bufo gargarizans cantor skin extract dry powder inhalant and preparation method and use thereof

A dry powder inhaler and dry powder inhaler technology are applied in the application field of preparing medicines for treating lung tumors, which can solve problems such as no research reports, and achieve the effects of no liver first pass, convenient application, and small adverse reactions.

Active Publication Date: 2011-10-12
南通思启高家具有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the study of toad skin extract dry powder inhalation with anti-lung tumor effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation of toad skin extract: wash dry toad skin, add 10 times the amount of water, decoct twice for 1.5 hours each time, combine the filtrate, concentrate to a relative density of 1.1-1.2 (85°C), and cool to Add ethanol for precipitation at 40°C to make the alcohol content reach 60%, let it stand for 24 hours, take the supernatant to recover the ethanol until it has no alcohol smell, add ethanol to the concentrated solution to make the alcohol content reach 85%, let it stand for 48 hours, filter , recover ethanol to a thick paste, and dry at 60°C to obtain toad skin extract.

[0030] 2. Preparation of the inhalant: the toad skin extract was pulverized to D 50 Below 5 microns, mix with lactose with a particle size of 45-70 microns in a mass ratio of 1:10, pack the drug powder into capsules or blisters or dry powder inhalers to obtain inhalers.

Embodiment 2

[0032] 1. Preparation of toad skin extract: Take dry toad skin and wash it, add 12 times the amount of water, decoct twice for 2 hours each time, combine the filtrate, concentrate to a relative density of 1.2-1.3 (85°C), and cool to Add ethanol for precipitation at 40°C to make the alcohol content reach 70%, let it stand for 24 hours, take the supernatant solution and recover the ethanol until there is no alcohol smell, add ethanol to the concentrated solution to make the alcohol content reach 85%, let it stand for 48 hours, filter , recovering ethanol to no alcohol smell, spray drying, to obtain toad skin extract powder, powder D 50 Below 5 microns.

[0033] 2. Preparation of inhalant: mix toad skin extract powder, lactose with a particle size of 45-80 microns, and leucine with a particle size of 20-50 microns in a mass ratio of 10:100:1, pack into Capsules or blisters or dry powder inhalers, get inhalers.

Embodiment 3

[0035] 1. Preparation of toad skin extract: Take dry toad skin and wash it, add 30 times the amount of water, microwave-assisted extraction 3 times, each time for 1 hour, combine the extracts, and ultrafilter the ultrafiltration membrane with a molecular weight of 1000, and the ultrafiltrate Spray drying to obtain toad skin extract powder, powder D 50 Below 5 microns.

[0036] 2. Preparation of inhalant: pack toad skin extract powder into capsules or blisters or dry powder inhaler to obtain inhaler.

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Abstract

The invention relates to dry powder inhalants, in particular to a dry powder inhalant prepared from bufo bufo gargarizans cantor skin extract, the preparation method of the dry powder inhalant and the use of the dry powder inhalant in preparation of medicines for treating lung tumors. The dry powder inhalant is characterized by consisting of bufo bufo gargarizans cantor skin extract and medicallyacceptable auxiliary material in a mass ratio ranging from 1:0 to 1:110. The dry powder inhalant made of the bufo bufo gargarizans cantor skin extract can directly act on lung diseases with less toxic and side reactions and high medicine bioavailability; the dry powder inhalant can overcome the drawbacks of slow effectiveness, undesirable liver firstpass effect, body toxic and side effects, low biological bioavailability and the like; and the dry powder inhalant also can solve the problems of inconvenient use, low obedience in patients and the like of powder injections.

Description

Technical field: [0001] The invention relates to a dry powder inhaler, in particular to a dry powder inhaler made of toad skin extract, a preparation method of the dry powder inhaler and an application in the preparation of a drug for treating lung tumors. Background technique: [0002] Cinobufacin is an extract obtained by extracting and purifying the dried skin of Bufobufo gargarizans Cantor, an animal of the Bufonidae family. It has the effects of detoxification, swelling, and pain relief. etc., the physiologically active substances are mainly bufotoxins and their hydrolysis products bufageins, bufoteinines and so on. At present, cinobufacin injections, oral liquids, and tablets have been used clinically, and have good curative effects on liver cancer, lung cancer, and gastric cancer. In particular, cinobufacin injection, which is a water-soluble preparation processed from the skin of Bufo bufo, has achieved comprehensive effective rates of 44% and 56% in the treatment o...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K9/14A61K9/16A61P35/00A61K35/65
Inventor 陈彦张振海贾晓斌王晋艳贺俊杰
Owner 南通思启高家具有限公司
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