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Preparation method of antifungal tablet

A technology for antifungal drugs and tablets, which is applied in the field of preparation of antifungal drugs, can solve the problems of improper addition of excipients, disintegration time, difficult quality control, low dissolution limit, etc., and achieve strong effect on superficial fungal infection and good formability Good quality stability and oral absorption

Inactive Publication Date: 2011-09-28
哈尔滨乐泰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of complex process, high cost, difficult quality control, prolonged disintegration time and low dissolution limit caused by improper addition of auxiliary materials in the preparation of existing terbinafine hydrochloride tablets, and to provide an antifungal Preparation method of pharmaceutical tablet

Method used

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  • Preparation method of antifungal tablet
  • Preparation method of antifungal tablet
  • Preparation method of antifungal tablet

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specific Embodiment approach 1

[0011] Specific embodiment one: the preparation method of the antifungal drug tablet of the present embodiment is carried out according to the following steps: one, take by weight 100~150 parts of terbinafine hydrochloride, 4~8 parts of binder, 8 parts by weight ~15 parts of carboxymethyl starch sodium, 50~60 parts of starch and 0.5~3 parts of magnesium stearate; 2. Place the weighed terbinafine hydrochloride, starch and 6~10 parts of carboxymethyl starch sodium Mix in a mixing tank for 20 minutes, then add binders to mix to make soft materials, pass through a 14-mesh sieve for granulation, pass through a 14-mesh sieve for granulation after drying, add the weighed magnesium stearate and the remaining amount of carboxymethyl starch sodium, After mixing and pressing into tablets, the preparation of antifungal drug tablets is completed; in step 1, the binder consists of hypromellose solution with a mass concentration of 1% to 10% and starch slurry with a mass concentration of 4% t...

specific Embodiment approach 2

[0014] Specific embodiment two: What this embodiment differs from specific embodiment one is that in step one, take by weight 100 parts of terbinafine hydrochloride, 4 parts of adhesive, 8 parts of sodium starch glycolate, 50 parts of starch and 0.5 parts of magnesium stearate. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0015] Specific embodiment three: the difference between this embodiment and specific embodiment one is that in step one, take by weight 150 parts of terbinafine hydrochloride, 8 parts of adhesive, 15 parts of sodium starch glycolate, 60 parts starch and 3 parts magnesium stearate. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention discloses a preparation method of an antifungal tablet and solves the problems of complex process, high cost and high quality control difficulty in the preparation of traditional Terbinafine hydrochloride tablets. The method comprises the steps of: 1, weighing Terbinafine hydrochloride, adhesive, carboxyrnethyl starch sodium, starch and magnesium stearate; and 2, putting and mixing the Terbinafine hydrochloride, the starch and a part of carboxyrnethyl starch sodium in a mixing tank, then adding and mixing the adhesive with the mixture, pelletizing, drying and finishing, adding the magnesium stearate and the rest carboxyrnethyl starch sodium, mixing and tabletting. In the preparation method of the antifungal tablet provided by the invention, by the use of the composite adhesive, the compressibility of drug particles and promote drug disintegration can be enhanced, tight tabletting and good adhesive force are obtained, the obtained tablets are bright and free from sticking, the degree of disintegration is remarkably reduced, the drug solubility is improved, the preparation process is simple in implementation, the cost of raw materials and accessories for every tablet is less than 1 Yuan, therefore, the price is low, and the product quality can be easily controlled.

Description

technical field [0001] The invention relates to a preparation method of antifungal medicine. Background technique [0002] Terbinafine hydrochloride can interfere with the metabolism of fungi. It can specifically inhibit the squalene epoxidase of fungi, and finally rupture the cell membrane to achieve the effect of killing fungi. Oral absorption is good, and it is mainly distributed in the stratum corneum of the skin at a high concentration. It has a strong effect on superficial fungal infections. External application or short-term oral administration can cure most skin fungal diseases, and has no effect on normal mammalian cells. This is Terbinafine hydrochloride and other allylamine antifungals have a unique bactericidal method. [0003] Terbinafine hydrochloride is a lipophilic and keratophilic compound, so it diffuses readily to the skin and nails. Terbinafine is the first drug that can effectively treat onychomycosis and has been widely promoted around the world. Te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/137A61K47/36A61P31/10
Inventor 郎伟君
Owner 哈尔滨乐泰生物科技有限公司
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