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Extract for treating pharyngolaryngitis and preparation method thereof

An extract and technology for pharyngitis, applied in the field of extracts for treating pharyngitis and its preparation, can solve problems such as the loss of volatile active ingredients, and achieve the effect of significant effect, improved practicability, and high extraction rate

Active Publication Date: 2013-01-23
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problem of large loss of volatile active ingredients in the direct water extraction method, and effectively enrich the main ingredients of each medicinal material

Method used

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  • Extract for treating pharyngolaryngitis and preparation method thereof
  • Extract for treating pharyngolaryngitis and preparation method thereof
  • Extract for treating pharyngolaryngitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of Example 1 "Anti-pharyngitis" Extract

[0029] Take 2 kg of Nepeta Nepeta, 8 kg of Platycodon grandiflorum, and 4 kg of raw licorice, and dry them at 40°C for 3 hours; crush the medicinal materials to a particle size of about 200 mesh. Then add 0.4 kg of methanol as an entraining agent, and extract in the separation tank of supercritical carbon dioxide extraction. The stage decompression separation pressure is 5Mpa, and the temperature is 35°C. The extract was collected as sample 1.

[0030] The outstanding advantages of this process technology are: (1) high extraction efficiency; (2) effectively enriching the main active ingredients, especially for terpenoids, etc. Basically, a large amount of such ingredients are lost, so that the application effect of the main drug is limited, and the volume of the extract is small, which improves the internal quality of traditional Chinese medicine; (3) fully removes impurities such as its polysaccharides; (4) reduce...

Embodiment 2

[0031] Preparation of Example 2 "Anti-pharyngitis" Extract

[0032] Take 2 kg of Nepeta Nepeta, 8 kg of Platycodon grandiflorum, and 4 kg of raw licorice, and dry them at a temperature of 60°C for 3 hours; grind the medicinal materials to a particle size of about 60 mesh. Put the dry powder in the extraction tank, add 15 kg of ethanol as an entrainer, and perform the first-stage decompression separation in the separation tank of supercritical carbon dioxide extraction. The pressure is 10Mpa and the temperature is 60°C; ℃. The extract was collected as sample 2.

Embodiment 3

[0033] Example 3 "Schizonepeta Soup" is prepared according to the traditional method recorded in ancient prescriptions

[0034] Take 2 kg of Nepeta Nepeta, 8 kg of Platycodon grandiflorum, and 4 kg of raw licorice, according to the traditional preparation method: add water, heat and reflux to extract twice, and concentrate the extract into a dry extract, which is used as sample 3. For comparison of samples 1 and 2.

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Abstract

The invention discloses an extract for treating pharyngolaryngitis. Medicinal materials such as 1 part of fine-leaf schizonepeta herb, 4 parts of platycodon root and 2 parts of raw liquorice are prepared by weight. The extract is prepared by the following steps of: 1) drying the medicinal materials, wherein the drying temperature is 40 to 60 DEG C, and the drying time is 3 to 4 hours; 2) crushing the medicinal materials into coarse powder; 3) filling the medicinal materials into a supercritical extraction tank, adding ethanol or methanol serving as an entrainer, and performing extraction for 3 to 4 hours under the conditions that the pressure is 5 to 10MPa, the temperature is 40 to 60 DEG C and the flow is 15 to 20L / h in the primary reduced pressure separation, and the pressure is 5 to 10MPa and the temperature is 35 to 50 DEG C in the secondary reduced pressure separation; and 4) dehydrating and drying the extract. By the supercritical preparation process, flavone, saponin and terpene components can be effectively enriched. The extract is characterized by comprising the following components in percentage by weight: more than or equal to 2.8 percent of glycyrrhizinic acid, more than or equal to 0.7 percent of liquiritin, more than or equal to 0.3 percent of platycodon D and 0.04 percent of menthone. The extract has anti-inflammatory and analgesic effects, and has more remarkable curative effect; and the preparation process is simple, the extraction rate is high, and the cost is low.

Description

technical field [0001] The present invention relates to an extract for treating pharyngitis and a preparation method thereof, in particular to an extract of a classic traditional Chinese medicine compound "Jiejie Decoction" and a preparation method thereof, and the use of the extract in the preparation of medicines for preventing and / or treating pharyngitis Applications. Background technique [0002] Pharyngitis belongs to the category of "throat numbness" in Chinese medicine. Modern medicine believes that it is an acute inflammation of the pharyngeal mucosa caused by pathogenic bacteria such as hemolytic streptococcus, staphylococcus, and pneumococcus. Traditional Chinese medicine believes that it is mostly caused by heat and evil poison that invades the throat, internally injures the lungs, and fights each other, causing throat swelling and pain; . The main clinical manifestations are pharyngeal redness, pain, dry itching, discomfort and foreign body sensation, often ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/538C12G3/04A61P11/04
Inventor 严启新李勇高媛陈萍
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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