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Chinese medicinal composition and preparation method thereof

The technology of a composition and a traditional Chinese medicine preparation is applied in the field of traditional Chinese medicine composition and its preparation, and can solve the problems such as low transfer rate of effective components, high leaching rate of ineffective components and influence on drug efficacy and the like

Inactive Publication Date: 2011-09-14
史志辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the traditional Chinese medicine tablets for the treatment of bacillary dysentery and acute and chronic gastroenteritis made by these three kinds of Chinese medicinal materials can cover the bad smell and taste of the medicine, improve the stability of the medicine, improve the bioavailability of the medicine, be easy to swallow, convenient to take, The dosage is accurate, easy to carry and store, but during its preparation, the transfer rate of active ingredients is low, only 60-70%, and the leaching rate of ineffective ingredients is too high to affect the efficacy

Method used

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  • Chinese medicinal composition and preparation method thereof
  • Chinese medicinal composition and preparation method thereof
  • Chinese medicinal composition and preparation method thereof

Examples

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preparation example Construction

[0032]The invention provides a preparation method of a traditional Chinese medicine composition. The raw materials include: 2,280-11,400 parts by weight of Flying Grass, 1,140-5,700 parts by weight of Futanmu, and 580-2,900 parts by weight of Jiubing;

[0033] Step 1: Take 456-2280 parts by weight of Jiubing, mix with 2280-11400 parts by weight of Feiyangcao, and 1140-5700 parts by weight of Futan mother, add 8 times the weight of deionized water for the first decoction for 2 hours, Collect the decoction; add 6 times the weight of deionized water for the second decoction for 1 hour, collect the decoction, combine it with the decoction described for the first time, filter and collect the filtrate, and concentrate it into a thick liquid with a relative density of 1.25-1.30 paste;

[0034] Step 2: Pulverize the remaining amount of jiubing and pass through a 100-mesh sieve to obtain jiubing fine powder;

[0035] Step 3: adding the Gubing fine powder into the thick ointment to pre...

Embodiment 1

[0046] The influence of each parameter on the extraction effect in the preparation method of embodiment 1 Chinese medicine composition

[0047] The amount of water added for the first decoction was fixed, and the influence of the amount of water added for the second time and the time of two decoctions on the transfer rate of medicinal active ingredients was investigated:

[0048] Weigh 2280g of Feiyangcao, 1140g of Huotanmu, and 456g of Jiubingying, add water to decoct twice, add water for the first time to be 8 times the total amount of the three raw materials, decoct and extract according to the orthogonal test conditions, and combine the decoction, Filtrate, concentrate the filtrate into a thick paste with a relative density of 1.25-1.30 (70°C), dry and pulverize through a 100-mesh sieve to obtain a dry paste fine powder, accurately weigh the total amount of the dry paste fine powder, and use high-performance liquid chromatography The percentage content of the above four ac...

Embodiment 2

[0091] Embodiment 2 The preparation method provided by the present invention affects the transfer rate of active ingredients

[0092] Weigh 4560g of Feiyangcao, 2280g of Huotanmu, and 912g of Jiubingying. According to the optimal decoction conditions selected in Example 1, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, and decoct for the second time Add 6 times the amount of water, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate into a thick paste with a relative density of 1.25-1.30 (70°C), dry and pulverize through a 100-mesh sieve to obtain a dry paste powder, which is precisely weighed The total amount of fine powder of the dry paste, and the percentage content of the above four active ingredients in the original medicinal materials were determined by high performance liquid chromatography, and the percentage content of the original medicinal materials was determined to obtain the transfer ra...

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Abstract

The invention discloses a preparation method for a Chinese medicinal composition, which comprises the following steps of: mixing 456 to 2,280 weight parts of ovateleaf holly bark in 580 to 2,900 weight parts of ovateleaf holly bark, 2,280 to 11,400 weight parts of garden euphorbia herb and 1,140 to 5,700 weight parts of Chinese knotweed herb, adding deionized water in an amount which is 8 times the weight of the mixture, decocting for the first time for 2 hours and collecting decoction; adding the deionized water in an amount which is 6 times the weight of the mixture, decocting for the second time for 1 hour, collecting decoction, mixing the two-time decoction, filtering, collecting filter liquor, and concentrating to form thick paste with the density of between 1.25 and 1.30; and adding the residual weight parts of ovateleaf holly bark into the thick paste, and sieving with a 100-mesh sieve to prepare ovateleaf holly bark fine powder, namely the Chinese medicinal composition. In the preparation method, the transfer rate of medicinal active ingredients is improved to over 96 percent, and the leaching of invalid ingredients is reduced. The prepared Chinese medicinal composition has an obvious treatment effect on bacillary dysentery and acute and chronic gastroenteritis (P is less than 0.05).

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Bacillary dysentery is an intestinal infectious disease caused by Shigella, with colon suppurative inflammation as the main lesion, and systemic poisoning symptoms, abdominal pain, diarrhea (often frequently expelling blood, pus and mucus), and tenesmus as the main clinical manifestations. [0003] Acute gastroenteritis is divided into exogenous and endogenous two categories. Exogenous acute gastritis includes simple and corrosive; endogenous acute gastroenteritis includes infectious and suppurative. Simple gastroenteritis can be caused by chemicals, physical irritants, or oral bacteria and bacterial toxins. Corrosive gastroenteritis is caused by oral administration of corrosive agents such as strong acids. Infectious gastroenteritis is caused by bacteria or ba...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P1/00A61P1/12A61P31/04
CPCY02A50/30
Inventor 史志辉
Owner 史志辉
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