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Method for detecting medicinal composition for treating urinary system diseases

A technology of urinary system diseases and composition, which is applied in the field of pills for the treatment of chronic prostatitis, and can solve problems such as unsatisfactory curative effect

Active Publication Date: 2011-08-10
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the clinical symptoms of acute and chronic urinary system diseases such as pyelonephritis, chyluria, prostatitis, gout, chronic nephritis, and chronic pelvic inflammatory disease are different, TCM syndrome differentiation studies have found that these diseases all have a pathological state of positive deficiency and evil excess. Insufficiency of the spleen and kidney, and the evil is the accumulation of dampness and heat. Traditional Chinese medicine mostly uses the method of promoting dampness and removing turbidity, but the curative effect is not satisfactory.

Method used

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  • Method for detecting medicinal composition for treating urinary system diseases
  • Method for detecting medicinal composition for treating urinary system diseases
  • Method for detecting medicinal composition for treating urinary system diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0094] Experimental example 1. Screening of quality detection methods

[0095] Screening of identification methods

[0096] 1. Fen 萆薢

[0097] method one:

[0098] Preparation of the test solution: take an appropriate amount of the content of the pharmaceutical composition preparation, grind it finely, get the fine powder equivalent to 2g of the raw medicinal material, put it in a 100mL conical flask with a stopper, add ethanol water bath and reflux to extract 3 times, each 20mL, Each time for 30 minutes, the extracts were combined, and the solvent was recovered to dryness. Add 20 mL of 2 mol / L hydrochloric acid to the residue, reflux in boiling water for 3 hours, take it out, cool it, place it in a separatory funnel, add chloroform for extraction 3 times, 10 mL each time, combine the chloroform liquid, evaporate it in a water bath to about 3 mL, and use it as the test solution;

[0099] Negative control solution preparation: Weigh the prescription Chinese herbal medicines ...

experiment example 2

[0271] Experimental example 2. Pharmacodynamics experiment

[0272] 1.1 Experimental materials

[0273] Drug group I (660g in total): 320g of fennel, 60g of calamus, 160g of licorice, 80g of black medicine, 40g of Yizhiren (stir-fried)

[0274] Drug group II (total 660g): 207g of fennel, 39g of Shichangpu, 104g of licorice, 52g of black medicine, 26g of Yizhiren (stir-fried), 155g of dodder, 77g of poria cocos

[0275] Testosterone Propionate Injection, produced by Shanghai Ninth Pharmaceutical Factory;

[0276] Qianliekang Tablets are produced by Zhejiang Yunshan Pharmaceutical Factory. Diethylstilbestrol tablets, produced by Beijing Xiangyang Pharmaceutical Factory;

[0277] Sodium pentobarbital, imported from Shanghai Pharmaceutical Purchasing Station;

[0278] Testosterone, estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin radioimmunoassay kit, produced by Tianjin Depu Biotechnology and Medical Products Co., Ltd.;

[0279] Animals Wistar male rat...

Embodiment 1

[0322] Fen 萆薢 320g Shichangpu 60g Licorice 160g

[0323] Wuyao 80g Yizhiren (stir-fried) 40g Cuscuta 240g

[0324] Poria cocos 120g

[0325] The above seven flavors are made into clinically acceptable preparations according to conventional techniques in the art, such as: granules, capsules, tablets, soft capsules, and pills.

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Abstract

The invention discloses a method for detecting a medicinal composition for treating urinary system diseases. The medicinal composition comprises 200-400 parts by weight of rhizoma dioscoreae hypoglaucae, 30-90 parts by weight of grassleaf sweelfal rhizome, 100-200 parts by weight of liquorice, 50-120 parts by weight of combined spicebush root, 20-80 parts by weight of fried sharpleaf galangal fruit, 200-300 parts by weight of dodder, 80-160 parts by weight of tuckahoe and the like. In the quality controlling method of the composition, the contents of diosgenin and glycyrrhizic acid are determined by adopting high performance liquid chromatography; and the rhizoma dioscoreae hypoglaucae, the grassleaf sweelfal rhizome, the liquorice, the fried sharpleaf galangal fruit and the combined spicebush root are subjected to qualitative thin layer identification. The composition has the efficacies of separating clear and resolving turbidity, warming kidney and removing dampness through diuresisand is used for the situations of the unsmooth flow of qi in the kidney, no separation of the clear from the turbid, frequent urination, as well as ongoing whitish turbidity.

Description

[0001] The present invention is a divisional application, the original application number is 200710121722.2, the original application date is September 13, 2007, and the original invention name is: a pharmaceutical composition for treating urinary system diseases and its quality control method. technical field [0002] The invention relates to a pharmaceutical composition for treating diseases of the urinary system, in particular to a medicinal composition for the treatment of chronic prostatitis, which is prepared from fennel, dodder, calamus, licorice, black medicine, yizhiren (stir-fried), and poria as raw materials. The pill belongs to the technical field of traditional Chinese medicine. Background technique [0003] Although the clinical symptoms of acute and chronic urinary system diseases such as pyelonephritis, chyluria, prostatitis, gout, chronic nephritis, and chronic pelvic inflammatory disease are different, TCM syndrome differentiation studies have found that the...

Claims

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Application Information

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IPC IPC(8): A61K36/9062G01N30/02G01N30/90A61P13/08
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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