Preparation method for extracting chlorogenci acid from honeysuckle and application of honeysuckle extract

Abstract

The invention provides a honeysuckle extract and a preparation method for extracting chlorogenci acid. The method has the advantages of good repeatability and good stability; by using the method, the content of an active component can be improved, a large amount of impurities are removed, raw materials are high in yield and low in cost; and the method is suitable for industrial production. The percentage of the main active component chlorogenci acid in the honeysuckle extract is 30%. The preparation process of the honeysuckle extract comprises the following steps: adding water the volume of which is 8-20 times as large as that of taken honeysuckle medicinal material in the taken honeysuckle medicinal to extract for 2-4 times for 0.5-1.5 hours each time; regulating the pH value of the extract to 1-6; and on a large pore absorption resin column, eluting impurities with water firstly, then eluting with 10-70% ethanol, colleting ethanol eluent, recovering the ethanol, concentrating, regulating the pH value of a concentrated liquid to 1-6, adding ethyl acetate for extraction, recovering the ethyl acetate, concentrating and drying. By using the method, the content of the active component in the extract is improved, the curative effect is improved, a large amount of impurities are removed, the problem of large moisture absorption commonly occurring in Chinese patent medicines is solved, and side effects are reduced.

Description

technical field [0001] The invention relates to a honeysuckle extract, a method for extracting chlorogenic acid from the traditional Chinese medicine honeysuckle, and the application of the extract in dosage forms such as tablets, granules, and capsules, and in preparing heat-clearing, detoxifying, and anti-infective drugs. Background technique [0002] This product is the dry flower bud or the first flower of Lonicera japonica Thunb. Harvest before the flowers bloom in early summer and dry them; or smoke them with sulfur and then dry them. Mostly produced in Shandong and Henan, mostly cultivated. The main effect is to clear away heat and detoxify, cool and dispel wind-heat. For carbuncle swollen furuncle, sore throat, erysipelas, pyretic toxin bloody dysentery, wind-heat cold, febrile disease heating. [0003] In recent years, scholars at home and abroad have carried out comprehensive analysis and research using modern theoretical knowledge, and done a lot of pharmacolog...

AI Technical Summary

Problems solved by technology

At present, most of the products containing honeysuckle are traditional Chinese medicine products with complex prescriptions. Although they have a certain curative effect, they also have disadvantages such as large dosage, slow onset of effect, inconvenient use, limited efficacy and difficult quality control.

[0004] The main active ingredient of honeysuckle is chlorogenic acid. We mainly use chlorogenic acid in the extraction. The traditional preparation methods of honeysuckle extracts reported in the literature include water extraction, alcohol extraction, water extraction and alcohol precipitation, and alcohol extraction. Shen method, etc., but the composition of honeysuckle medicinal materials is complex and contains many components other than chlorogenic acid, so the content obtained by traditional preparation methods is generally low

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