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Chlorambucil/layered double hydroxides nano-hybrid and preparation method thereof

A chlorambucil and nano-hybrid technology, which is applied in the preparation of oxides/hydroxides, pharmaceutical formulations, drug combinations, etc., can solve problems such as serious toxic side effects, nervous system damage, etc., to reduce toxic side effects, reduce Drug toxicity and side effects, simple process effect

Inactive Publication Date: 2011-07-20
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is a cytotoxic drug, and its toxic and side effects are relatively serious, mainly in the damage to the bone marrow and nervous system.

Method used

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  • Chlorambucil/layered double hydroxides nano-hybrid and preparation method thereof
  • Chlorambucil/layered double hydroxides nano-hybrid and preparation method thereof
  • Chlorambucil/layered double hydroxides nano-hybrid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] a. 5.13g (0.02mol) Mg (NO 3 ) 2 ·6H 2 O and 3.75g (0.01mol) Al(NO 3 ) 3 9H 2 O was dissolved in 60 mL of deionized water.

[0033] b. Prepare a 6% ammonia solution.

[0034] c. Dissolve 0.30 g of chlorambucil in 40 mL of ethanol / water solution with a volume ratio of 1:1 containing 0.2 mol / L NaOH to prepare a chlorambucil solution with a concentration of 0.025 mol / L.

[0035]d. Add the solution of step b to the solution of step a, stir and control the pH to 9.5, and the reaction temperature is 30°C; the reaction time is 2 hours, then age the obtained slurry at 30°C for 3 hours, filter, and wash with water to neutral , Peptized at 80°C for 24 hours to obtain layered double hydroxides (LDHs); dry to obtain a powder product.

[0036] e. Disperse 0.4 g of the LDHs powder obtained in step d) into the solution in step c), mix well, and react at 60° C. for 3 days to obtain a chlorambucil / LDHs nanohybrid.

[0037] By XRD spectrum ( figure 1 b) It can be seen that the ch...

Embodiment 2

[0042] a. 5.13g (0.02mol) Mg (NO 3 ) 2 ·6H 2 O and 3.75g (0.01mol) Al(NO 3 ) 3 9H 2 O was dissolved in 60 mL of deionized water.

[0043] b. Prepare a 6% ammonia solution.

[0044] c. Dissolve 0.60 g of chlorambucil in 40 mL of ethanol / water solution with a volume ratio of 1:1 containing 0.2 mol / L NaOH to prepare a chlorambucil solution with a concentration of 0.05 mol / L.

[0045] d. Add the solution of step b to the solution of step a, stir and control the pH to 9.5, and the reaction temperature is 15°C; the reaction time is 2 hours, then the resulting slurry is aged at 15°C for 3 hours, filtered, and washed with water until neutral , Peptized at 80°C for 24 hours to obtain layered double hydroxides (LDHs); dry to obtain a powder product.

[0046] e. Disperse 0.4 g of the LDHs powder obtained in step d) into the solution in step c), mix well, and react at 60° C. for 3 days to obtain a chlorambucil / LDHs nanohybrid.

[0047] By XRD spectrum ( figure 1 c) It can be seen...

Embodiment 3

[0052] a, 4.06g (0.02mol) MgCl 2 ·6H 2 O and 2.41g (0.01mol) AlCl 3 9H 2 O was dissolved in 30 mL deionized water.

[0053] b. Prepare a NaOH solution with a concentration of 2 mol / L.

[0054] c. Dissolve 0.12 g of chlorambucil in 40 mL of ethanol / water solution with a volume ratio of 1:1 containing 0.2 mol / L NaOH to prepare a chlorambucil solution with a concentration of 0.01 mol / L.

[0055] d. Add the solution of step b to the solution of step a, stir and control the pH to 8, the reaction temperature is 45°C; the reaction time is 1 hour, then age the obtained slurry at 45°C for 8 hours, filter, and wash with water until neutral , Peptized at 60°C for 28 hours to obtain layered double hydroxides (LDHs); dry to obtain a powder product.

[0056] e. Disperse 0.4 g of the LDHs powder obtained in step d) into the solution in step c), mix well, and react at 20° C. for 5 days to obtain a chlorambucil / LDHs nanohybrid.

[0057] The sample was analyzed by ultraviolet spectrophoto...

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PUM

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Abstract

The invention relates to chlorambucil / layered double hydroxides (LDHs) nano-hybrid and a preparation method thereof. The chlorambucil / LDHs nano-hybrid prepared by taking LDHs as a carrier is used for controlled release of chlorambucil to improve pesticide effect and reduce toxic and adverse effects of medicament. The chlorambucil / LDHs nano-hybrid is prepared by taking the LDHs as a main body and chlorambucil as an intercalation object by assembling chlorambucil into layers of LDHs through ion exchange process. The hybrid provided by the invention has good effect of slow release of chlorambucil; the adopted preparation method has simple process and mild reaction; and the structure, composition and release rate of the chlorambucil / LDHs nano-hybrid can be realized through changing the synthesis conditions of the chlorambucil / LDHs, such as medicament concentration, synthesis temperature, aging time and other factors.

Description

technical field [0001] The invention belongs to the technical field of materials and pharmaceutical preparations, and relates to a chlorambucil / layered double metal hydroxide (LDHs) nano hybrid and a preparation method thereof. Background technique [0002] With the development of science and the advancement of science and technology, people's requirements for the treatment effect and treatment methods of diseases are increasing day by day. How to improve the curative effect, simplify the way of medication, and reduce the toxic and side effects of drugs is the research focus of scientific and technological workers. Especially for highly toxic drugs, in order to facilitate patients to take them, while ensuring the effective therapeutic concentration, reduce the toxic and side effects of drugs, and avoid the emergence of drug resistance, the effective delivery and controlled release of drugs is undoubtedly an effective method. way. In this effective approach, the development...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/196C01B13/14A61P35/00A61P35/02A61K47/52
Inventor 侯万国徐洁冉德焕赵继宽
Owner QINGDAO UNIV OF SCI & TECH
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