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Application of secoisolariciresinol in preparation of medicament for treating depression and anxiety

A technology of secoisolarix, depression, applied in the direction of drug combination, endocrine system diseases, nervous system diseases, etc., can solve problems such as breast cancer risk

Inactive Publication Date: 2013-05-22
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The low level of estrogen in the body is one of the main causes of depression and anxiety in the menopausal population. At present, the commonly used treatment method is estrogen replacement therapy (HRT), but long-term use of estrogen will cause endometrial cancer and breast cancer. Danger

Method used

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  • Application of secoisolariciresinol in preparation of medicament for treating depression and anxiety
  • Application of secoisolariciresinol in preparation of medicament for treating depression and anxiety
  • Application of secoisolariciresinol in preparation of medicament for treating depression and anxiety

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Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1, the application of secoisolaricine in the treatment of depression

[0018] 1. Preparation of secoisolaricine sample solution

[0019] Secoisolaricine was dissolved in 0.5% Tween 80 solution to prepare a 2mg / mL test solution.

[0020] Imipramine hydrochloride (Sigma, USA) was dissolved in 0.5% Tween 80 solution to prepare a 1 mg / mL solution.

[0021] 2. Grouping and administration

[0022] The mice were randomly divided into sham operation group, model group, (+)-SECO high-dose group, (+)-SECO middle-dose group, (+)-SECO low-dose group, (-)-SECO high-dose group, (-) -SECO middle-dose group, (-)-SECO low-dose group and imipramine group (positive control) consisted of nine groups, with 12 rats in each group. Drinking water freely, natural light, room temperature (23±1)℃, humidity (60±10)%; after feeding for three days, refer to the literature (KimuraN, YoshimuraH, Ogawa N Sexdifferences in stress induced gastric ulceration: effects of castration andovariecto...

Embodiment 2

[0066] Embodiment 2, the application of secoisolaricine in the treatment of anxiety

[0067] 1. Preparation of secoisolaricine sample solution

[0068] Secoisolaricine was dissolved in 0.5% Tween 80 solution to prepare a 2 mg / ml test solution.

[0069] Diazepam tablets (Beijing Yimin Pharmaceutical Co., Ltd., batch number: 0806009) were dissolved in 0.5% Tween 80 solution to prepare a 0.1 mg / ml solution.

[0070] 2. Grouping and administration

[0071] The mice were randomly divided into sham operation group, model group, (+)-SECO high-dose group, (+)-SECO middle-dose group, (+)-SECO low-dose group, (-)-SECO high-dose group, (-) -SECO middle-dose group, (-)-SECO low-dose group and diazepam group (positive control) consisted of nine groups, with 12 rats in each group. Drinking water freely, natural light, room temperature (23±1)℃, humidity (60±10)%; after feeding for three days, refer to the literature (Kimura N, Yoshimura H, Ogawa N Sex differences in stress induced gastric...

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Abstract

The invention discloses application of secoisolariciresinol in preparation of a medicament for treating depression and anxiety. The invention also provides the medicament for treating the depression and / or the anxiety, wherein the ingredient of the medicament is secoisolariciresinol. The secoisolariciresinol can promote the increment of monoamine neurotransmitter content of an ovary removed mouse, improve the medicament for the uterine function of the ovary removed mouse and improve the mouse behaviors of depression and anxiety models, and has the effect of resisting the depression and the anxiety. The invention provides a new path for treating the depression and the anxiety, and has great value.

Description

technical field [0001] The invention relates to the application of secoisolaricine in the preparation of medicines for treating depression and anxiety. Background technique [0002] Depression and anxiety are the main symptoms of menopausal syndrome, especially depression accounts for about 47% of menopausal syndrome patients. It is a chronic recurrent disease, characterized by emotional disturbance and persistent depression. Social function is significantly reduced, and the risk of suicide is high. Depression is often accompanied by anxiety. Currently clinically used antidepressants (such as imipramine, amitriptyline, doxepin, fluoxetine, etc.) and zolpidem, etc.) although the curative effect is definite, but it can cause drowsiness, dry mouth, nausea, vomiting weakness, blurred vision, constipation, rapid heartbeat, difficulty urinating and postural hypotension, and overdose can also cause acute poisoning and even death. side effect. Therefore, the development of safe ...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61P25/24A61P25/22A61P15/12A61P25/00A61P5/30
Inventor 杨东辉库宝善刘树林姚海燕
Owner PEKING UNIV
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