N-(rhodamine 6G) lactam-N'-phenylthiourea derivative fluorescent probe and preparation method

Abstract

The invention discloses an N-(rhodamine 6G) lactam-N'-phenylthiourea derivative. The N-(rhodamine 6G) lactam-N'-phenylthiourea derivative has the chemical structural formula shown as the specifications. The invention also discloses a preparation method of the N-(rhodamine 6G) lactam-N'-phenylthiourea derivative. The preparation method comprises the following steps of: reacting rhodamine 6G serving as a raw material with ammonia to prepare rhodamine 6G lactam; and reacting the rhodamine 6G lactam with phenylisothiocyanate to prepare the N-(rhodamine 6G) lactam-N'-phenylthiourea derivative. A fluorescent probe has the characteristics of increasing dissolution velocity in acetonitrile, enhancing stability of the pH value; stabilizing in acid alkaline environments and the like, and can serves as a probe for a fluorescent indicator of metal ions to detect heavy metal ion content and transition metal ion content of water.

Description

A kind of N-(rhodamine 6G) lactam-N'-phenylthiourea derivative fluorescent probe and preparation method thereof Technical field: The invention relates to a fluorescent probe-N-(rhodamine 6G) lactam-N'-phenylthiourea derivative and a preparation method thereof. Background technique: Rhodamine series compounds are important members of the xanthene dye family. The absorption and emission are at longer wavelengths, the fluorescence quantum yield is high, the extinction coefficient is large, and the photostability is good. It has attracted the attention of scientists for a long time. Due to its excellent optical properties, it is often used as a fluorescent probe for detecting trace metal ions. The selective recognition of metal ions by rhodamine-based dyes is through the complexation of metal ions and probe molecules, which induces the opening of the helical ring structure of the probe, thereby generating fluorescent signals. In view of this, long-wavelength fluorescent switc...

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Problems solved by technology

So far, the spiro rings in this type of compounds are mainly lactam and aromatic structures [Zhang Wenjuan, Wu Zengxi, et al. Spectroscopy and Spectral Analysis. 2010, 30(5): 1305; Li Honglin, Fan Jiangli, Liu Xiaojian, et al. Acta Chemical Sinica. 2010, 31(9): 1725. Zhang Lingfei, Zheng Xiangyong, Zeng Xi, et al. Acta Inorganic Chemistry. 2010, 26(7): 1183.], but the rhodamine in which the hydrogen in the imine group of the spiro ring is replaced Derivatives and their preparation methods are seldom reported

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