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Method for detecting medicinal composition for treating viral hepatitis

A detection method and composition technology, which can be used in drug combinations, antiviral agents, pharmaceutical formulations, etc., and can solve problems such as drug resistance, obvious side effects, and addiction.

Active Publication Date: 2013-03-27
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drugs currently used clinically for the treatment of viral hepatitis have certain curative effects, they have defects such as easy to cause drug resistance, addiction, and obvious side effects in the body to varying degrees.

Method used

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  • Method for detecting medicinal composition for treating viral hepatitis
  • Method for detecting medicinal composition for treating viral hepatitis
  • Method for detecting medicinal composition for treating viral hepatitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental example 1: Pharmacodynamic test of the drug group on the ability of protecting the liver, reducing enzymes, promoting choleretics, reducing jaundice, and phagocytic clearance

[0038] Pharmaceutical group I: take the pharmaceutical composition mixture prepared in Example 2 of the present invention

[0039] Pharmaceutical Group II: Take the pharmaceutical composition mixture prepared in Example 13 of the present invention

[0040] Control group: Commercially available Qingre Shugan mixture.

[0041] 1. Liver protection and enzyme reduction effect

[0042] 1. Protective effect on acute liver injury

[0043] Eighty-four Kunming mice, weighing 18-20 g, half male and half female, were randomly divided into 7 groups. The first group: the normal control group, the same amount of drinking water daily; the second group: the model group, the same amount of drinking water daily; the third group: the drug group I, the drug group I 30ml ( Equivalent to crude drug 9.32g) / kg body ...

experiment example 2

[0066] Experimental example 2 Excipient screening experiment

[0067] Optimization of the technological conditions for the inclusion of volatile oil β-cyclodextrin

[0068] Because the volatile oil is easy to dissipate, if the volatile oil is added directly, left for a long time or slightly heated, the volatile oil will be lost, thereby reducing the content and affecting the efficacy of the drug. In order to solve this problem, the β-cyclodextrin inclusion method was used, and the orthogonal test method was used to optimize the inclusion conditions.

[0069] See the attached drawings for the experiment process.

[0070] Adopting saturated aqueous solution method for inclusion: weigh a certain amount of β-cyclodextrin, add appropriate amount of distilled water, and heat in a 70℃ water bath to make a 5% β-cyclodextrin aqueous solution. At different temperatures (20℃, 40℃, 60℃) Stir at a speed of 2500 rpm, add quantitative volatile oil, stir well for a certain period of time to obtain i...

experiment example 3

[0081] Experimental example 3 Identification test of Yinchen

[0082] The blank sample is prepared according to the medicine composition and dosage ratio of the present invention, and the group medicines without Yinchen, Radix Paeoniae Rubra, Angelica, Salvia, Polygonum cuspidatum are prepared separately, and the blank preparation is prepared according to the preparation process.

[0083] Preparation of blank solution Take a 14 / 1000 daily dose of a blank sample of the preparation of this pharmaceutical composition, add 20ml of water to dissolve it, and extract twice with ethyl acetate, the first time is 30ml, the second time is 20ml, and the ethyl acetate solution is combined , Evaporate to dryness in a water bath, add 1ml ethyl acetate to the residue to dissolve it as a blank solution.

[0084] Preparation of the sample solution Take the same amount of the drug group and substance samples, and prepare the sample solution according to the preparation method of the blank solution.

[0...

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Abstract

The invention discloses a method for detecting a medicinal composition for treating viral hepatitis. The medicinal composition is prepared from the following raw material medicaments: virgate wormwood herb, indigowoad root, male fern rhizome, Indian buead, root-tuber of aromatic turmeric, barbed skullcap herb, patchouli and the like. The method for detecting the medicinal composition is obtained by screening a great number of specific creative tests. In an identification method, the identification specificity is high by screening sample processing methods and selecting a developing solvent; and the method is economic and practical, is used for quickly acquiring results and can be applied to different thin layer plates. In a content detecting method, the quality of products can be effectively controlled by screening samples and sample supply processing methods and selecting the developing solvent. The products detected by the method have more stable medicinal effects than products detected by other methods.

Description

[0001] This invention is a divisional application, the original application number is 200710119920.5 , The original application date is 2007 August 3 , The original name is Medicine composition and quality control prescription for treating viral hepatitis law . Invention field [0002] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a pharmaceutical composition for treating viral hepatitis, a preparation method and a quality control method. Background technique [0003] Viral hepatitis is a common infectious disease caused by a variety of hepatitis viruses. It has the characteristics of strong contagion, complicated transmission routes, wide spread, and high incidence. The main clinical manifestations are fatigue, loss of appetite, nausea, vomiting, hepatomegaly and liver damage. Some patients may have jaundice and fever. Some patients develop urticaria, joint pain, or upper respiratory tract symptoms. In...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/90A61K36/9066A61K36/9064A61K36/896A61P1/16A61P31/14A61P31/20A61K35/10
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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