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Chinese medicine effective part composition with antitumor effect and preparation method thereof

A technology with anti-tumor effect and effective parts, which can be used in anti-tumor drugs, drug combinations, medical preparations containing active ingredients, etc. , the effect of high safety

Inactive Publication Date: 2013-04-17
NANJING TIANYUAN PEPTIDE PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, surgery is the simplest, but only has a more thorough treatment effect on early cancers; radiation therapy is an adjuvant therapy, which has poor accuracy and large side effects; biological therapy is a new tumor treatment method that has just emerged in the past ten years. In research and development, it is only effective for a small number of tumors clinically, most of which are not obvious; chemical drug therapy (also known as chemotherapy) is currently the most important treatment for cancer clinical treatment, but there are still toxic side effects, tumor cell drug resistance, etc. Problems that greatly limit the clinical application of chemotherapy

Method used

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  • Chinese medicine effective part composition with antitumor effect and preparation method thereof
  • Chinese medicine effective part composition with antitumor effect and preparation method thereof
  • Chinese medicine effective part composition with antitumor effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Preparation of total flavonoids from Hedyotis diffusa and Astragalus total polysaccharides from Hedyotis diffusa

[0111] Preparation method: Take Hedyotis diffusa and Radix Astragali (3:1, w / w), add 12 times the amount of 80% ethanol to reflux and extract twice, each time for 1.5 hours, filter, and use the dregs for later use; combine the filtrates, and recover under reduced pressure Ethanol, add water to dilute the concentrated solution, pass through the macroporous resin column according to the amount of resin: medicinal material amount 1:1, first elute with 6 times the amount of deionized water, then elute with 8 times the amount of 70% ethanol, collect the eluate, reduce The ethanol is recovered under pressure, concentrated, and dried to obtain the active parts of total flavonoids. Take the above medicinal residues, add 15 times the amount of water to extract 3 times, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to 1g cru...

Embodiment 2

[0113] Preparation of Denon Small Peptide

[0114] Preparation method: Take Tianlong, crush it properly, pass through a 50-mesh sieve, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2, and then add pepsin with 3% substrate amount, Enzymolysis at 45°C for 3 hours, then use 20% sodium hydroxide solution to adjust the pH to 8, add trypsin with 1% substrate amount, and enzymatic hydrolysis at 50°C for 4 hours, stir frequently and adjust the pH to 8-8.5 Within the range, after the enzymolysis is completed, continue to heat up and boil for 5 minutes, let cool, centrifuge, concentrate under reduced pressure to a clear paste of 4:1 (ml / g), add solid paraffin with 40% medicinal material, heat and melt, and stir evenly, and refrigerate Overnight, take out the paraffin layer, filter, the filtrate is concentrated under reduced pressure, and dried to obtain the obtained pro...

Embodiment 3

[0116] Preparation of total flavonoids and total polysaccharides of Astragalus barbatae

[0117] Preparation method: Take Scutellaria barbata and Radix Astragali (3:1, w / w), add 10 times the amount of 60% ethanol to reflux and extract twice, each time for 1.5 hours, filter, and use the dregs for later use; combine the filtrates, and recover ethanol under reduced pressure , add water to dilute the concentrated solution, pass through the macroporous resin column according to the amount of resin: medicinal material amount 1:1, first elute with 8 times the amount of deionized water, then elute with 10 times the amount of 70% ethanol, collect the eluate, and decompress The ethanol is recovered, concentrated, and dried to obtain the effective fractions of total flavonoids. Take the above medicinal residues, add 20 times the amount of water to extract 3 times, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to 1g crude drug / ml, add ethanol to ...

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Abstract

The invention discloses a Chinese medicine effective part composition with an antitumor effect and a preparation method thereof, in particular to a Chinese medicine effective part composition extracted from oldenlandia diffusa, astragalus mongholicus and centipede and a preparation method thereof, belonging to the field of traditional Chinese medicines. In the Chinese medicine composition, effective parts are extracted from the oldenlandia diffusa, the astragalus mongholicus and the centipede as main ingredients, then corresponding auxiliary materials are added so as to prepare pills, tablets, granules, hard capsules, mixtures, pill drops, soft capsules, effervescent tablets, injections or powder-injections used for inhabiting tumor growth, reducing a tumor body, adjusting immunologic function, improving immunity of a human body, prolonging the life of a patient with the tumor, effectively relieving adverse reactions such as leucopenia, dizziness, tireness, weakness, magersucht, poor appetite, nausea and vomiting and the like caused by operation, radiotherapy or chemotherapy of the patient with the tumor; and the Chinese medicine effective part composition has the advantages of definite effective ingredients, obvious drug effect, less dosage and diversified formulation, is convenient to use, conforms to the modern requirements on the traditional Chinese medicine and has betterdevelopment prospect.

Description

technical field [0001] The invention relates to a composition of effective parts of traditional Chinese medicine with antitumor effect and a preparation method thereof, in particular to a composition of effective parts of traditional Chinese medicine extracted from Hedyotis diffusa, Radix Astragali and Tianlong and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Cancer is the No. 2 killer of human beings, and it is also the most feared among all diseases. People almost turn pale when they talk about cancer. In essence, cancer is a disease induced by gene mutation. With the prolongation of human life expectancy and the aggravation of environmental pollution caused by industrialized production, the cumulative time of mutations becomes longer and the factors that induce mutations increase, thus leading to the incidence of tumors. Significantly increased. It is predicted that cancer will soon replace cardiovasc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/02A61K36/74A61P35/00A61P37/04
Inventor 魏永利代龙
Owner NANJING TIANYUAN PEPTIDE PHARMA TECH CO LTD
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