A kind of pharmaceutical composition for treating diabetic retinopathy

A technology for diabetic retina and composition, applied in the field of traditional Chinese medicine, can solve the problems of low content of active ingredients, loss of market competitiveness, and insignificant effects, and achieve the effects of stable curative effect, simple and clear chemical composition, and remarkable effect.

Inactive Publication Date: 2021-03-16
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Chinese medicine treatment has gradually lost its market competitiveness due to defects such as low active ingredient content, large dosage, and ineffective effects. Compared with traditional compound prescriptions, the composition of effective parts of Chinese herbal medicine that has the effect of treating diabetic retinopathy can achieve high ingredient content. , small dosage, good efficacy and clear therapeutic effect

Method used

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  • A kind of pharmaceutical composition for treating diabetic retinopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Prescription: Astragalus Ligustrum lucidum wine total glucosides of dogwood 240g, Chrysanthemum Angelica total phenolic acid 120g, Lycium barbarum malt water-soluble effective part 160g

[0083]Preparation method: Preparation of total glycosides of Astragalus Ligustrum Ligustrum wine and cornus: take astragalus, Ligustrum lucidum and cornus, crush them, add 14 times the amount of 70% ethanol to reflux and extract 3 times, each time for 2 hours, and combine ethanol The solvent is recovered from the extract, and dried to obtain an ethanol extract. After the ethanol extract is dissolved in a small amount of water, it is chromatographed on a D101 macroporous adsorption resin column according to the ratio of the amount of resin to the medicinal material at 1:1. It is first eluted with 6 times the amount of water, and then used 80% ethanol was eluted at a speed of 2BV / h, and the eluate of 4BV was collected; concentrated under reduced pressure, evaporated to dryness, and the to...

Embodiment 2

[0088] Prescription: astragalus wine Ligustrum lucidum wine 120g total glycosides of cornus, 60g total phenolic acids of chrysanthemum angelica, 80g water-soluble active parts of wolfberry malt

[0089] Preparation method: Preparation of total glycosides of Astragalus Ligustrum Ligustrum wine and cornus: take astragalus, Ligustrum lucidum and cornus, crush them, add 14 times the amount of 70% ethanol to reflux and extract 3 times, each time for 2 hours, and combine ethanol The solvent is recovered from the extract, and dried to obtain an ethanol extract. After the ethanol extract is dissolved in a small amount of water, it is chromatographed on a D101 macroporous adsorption resin column according to the ratio of the amount of resin to the medicinal material at 1:1. It is first eluted with 6 times the amount of water, and then used 80% ethanol was eluted at a speed of 2BV / h, and the eluate of 4BV was collected; concentrated under reduced pressure, evaporated to dryness, and the ...

Embodiment 3

[0094] Prescription: Astragalus wine Ligustrum lucidum wine 600g total glycosides of cornus, 300g total phenolic acids of chrysanthemum angelica, 400g water-soluble active parts of wolfberry malt

[0095] Preparation method: Preparation of total glycosides of Astragalus Ligustrum Ligustrum wine and cornus: take astragalus, Ligustrum lucidum and cornus, crush them, add 14 times the amount of 70% ethanol to reflux and extract 3 times, each time for 2 hours, and combine ethanol The solvent is recovered from the extract, and dried to obtain an ethanol extract. After the ethanol extract is dissolved in a small amount of water, it is chromatographed on a D101 macroporous adsorption resin column according to the ratio of the amount of resin to the medicinal material at 1:1. It is first eluted with 6 times the amount of water, and then used 80% ethanol was eluted at a speed of 2BV / h, and the eluate of 4BV was collected; concentrated under reduced pressure, evaporated to dryness, and th...

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Abstract

The invention discloses a drug combination for treatment of diabetic retinopathy, and belongs to the field of traditional Chinese medicine. The drug combination is formed by total glycosides extracted from membranous milkvetch roots, wine-prepared glossy privet fruits and wine-prepared fructus corni, total phenolic acid extracted from chrysanthemum and angelica sinensis, and a water-soluble component extracted from barbary wolfberry fruit and malt with a certain ratio, and conventional ingredients in the pharmacy are further added to be prepared into various forms of drugs. The drug combination for treatment of diabetic retinopathy can be clinically used for treating the diabetic retinopathy.

Description

technical field [0001] The present invention relates to a pharmaceutical composition with the effect of treating diabetic retinopathy and a preparation method thereof, specifically a combination of effective parts of traditional Chinese medicine extracted from astragalus, Ligustrum lucidum, chrysanthemum, medlar, angelica, cornus and malt A compound and a preparation method thereof belong to the field of traditional Chinese medicines. Background technique [0002] Diabetes mellitus (DM) is a lifelong endocrine disease with glucose metabolism disorder caused by various reasons. Currently, the number of DM patients in the world is about 240 million, and it is estimated that by 2025, the number will reach 350 million. Diabetic retinopathy (DR) is one of the most common and serious complications of DM. It is the reflection of DM metabolic disorder, endocrine and blood system damage on the retina, and is one of the main causes of blindness. Hyperglycemia is an important risk fac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8998A61P3/10A61P9/10A61P27/02
CPCA61K36/232A61K36/287A61K36/481A61K36/638A61K36/754A61K36/815A61K36/8998A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 代龙孙志强徐莉
Owner BINZHOU MEDICAL COLLEGE
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