Pharmaceutical composition for treating inflammatory infectious diseases and/or cardiovascular and cerebrovascular diseases and preparation method and application thereof

A technology for cardiovascular and cerebrovascular diseases and infectious diseases, applied in the field of medicine, can solve problems such as no combination

Inactive Publication Date: 2018-11-27
山东科迪臻药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chinese patent medicines for the treatment of diabetic nephropathy and cardiovascular and cerebrovascular diseases have occupied a certain market, but most of these medicines are only additions and subtractions on the basis of traditional Chinese medicine prescriptions, without combining the latest scientific research results of modern medicine

Method used

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  • Pharmaceutical composition for treating inflammatory infectious diseases and/or cardiovascular and cerebrovascular diseases and preparation method and application thereof
  • Pharmaceutical composition for treating inflammatory infectious diseases and/or cardiovascular and cerebrovascular diseases and preparation method and application thereof
  • Pharmaceutical composition for treating inflammatory infectious diseases and/or cardiovascular and cerebrovascular diseases and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Composition of raw materials: Salvia miltiorrhiza 500g, Astragalus 300g, Chuanxiong 200g;

[0067] Preparation method: Take the raw material according to the proportion, chop it up, mix it evenly, extract twice, add 10 times the weight of the medicinal material in water for the first time, soak and extract at 95°C for 2 hours, filter, collect the filtrate, continue to add 8 times the water to the filter residue , soaked and extracted at 95°C for 2 hours, filtered, combined the two extracts, settled for about 4 hours, filtered, and the filtrate was concentrated under reduced pressure at 60°C to a relative density of 1.20 under the condition of a vacuum of 0.09MPa. Clear the paste, place it at 60°C to vacuum-dry to obtain the extract and crush it, pass through an 80-mesh sieve, and take the sieved material for future use.

[0068] Weigh 50 parts of the above extracts, add 30 parts of mannitol, 0.004 parts of folic acid, mix well, add 60 parts of 95% ethanol as a wetting a...

Embodiment 2

[0070] Composition of raw materials: Salvia miltiorrhiza 500g, Astragalus 300g, Chuanxiong 200g;

[0071] Preparation method: Take the raw material according to the proportion, chop it up, mix it evenly, extract twice, add 10 times the weight of the medicinal material in water for the first time, soak and extract at 95°C for 2 hours, filter, collect the filtrate, continue to add 8 times the water to the filter residue , extract by warm soaking at 95°C for 2 hours, filter, combine the two extracts, concentrate under reduced pressure to 1ml approximately equal to 1g crude drug, stand still, add 95% ethanol to make the alcohol concentration reach 80%, after standing overnight, filter, The filtrate was concentrated under reduced pressure at 60°C to a clear paste with a relative density of 1.20 under the condition of a vacuum of 0.09MPa, then dried in a vacuum at 60°C to obtain an extract and crushed, passed through a 80-mesh sieve, and the under-sieve was taken for future use.

[...

Embodiment 3

[0074] Composition of raw materials: Salvia miltiorrhiza 400g, Astragalus 400g, Chuanxiong 200g;

[0075] Preparation method: Weigh 400g of Salvia miltiorrhiza, chop it up, extract twice, add water 10 times the weight of the medicinal material for the first time, soak and extract at 95°C for 2 hours, filter, collect the filtrate, continue to add 8 times the water to the filter residue, and put it at 95°C Warm soaking and extraction for 2 hours, filtering, combining two extracts, static sedimentation for about 4 hours, filtering, the filtrate was concentrated under reduced pressure at 60°C to a clear paste with a relative density of 1.20 under a vacuum of 0.09MPa, and placed Vacuum-dry at 60°C to obtain the extract and crush it, pass through a 80-mesh sieve, and take the under-sieve to obtain the salvia miltiorrhiza extract;

[0076] Weigh 400g of Radix Astragali, chop it up, add ethanol to extract twice, add 8 times the amount of 70% ethanol for the first time, heat and reflux...

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Abstract

The invention discloses a pharmaceutical composition for treating inflammatory infectious diseases and / or cardiovascular and cerebrovascular diseases and a preparation method and application thereof.The composition is prepared from, by weight, 20-90 parts of salviae miltiorrhizae, 10-80 parts of milkvetch roots, 5-50 parts of rhizoma chuanxiong and 0.001-0.005 parts of folic acid. According to the compositions, the three traditional Chinese medicines are matched according to the component, not only qi circulation but also blood circulation are promoted, qi assists in blood circulation, and then stasis is removed; folic acid is added, and from the perspectives of modern medicine, the very good supplementary function on diabetic nephropathy and cardiovascular and cerebrovascular disease prevention and treatment is achieved. The proportion of ingredients in the component has the high synergies, and the pharmaceutical composition is an ideal product for protecting heart and brain cells, preventing and treating the diabetic nephropathy and cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for preventing or treating inflammatory infectious diseases and / or cardiovascular and cerebrovascular diseases, its preparation method and application. Background technique [0002] Diabetic nephropathy (Diabetic Nephropathy, DN) is one of the most important complications of diabetic patients. The incidence rate in my country is also on the rise, and it has become the second cause of end-stage renal disease, second only to various glomerulonephritis. Due to its complex metabolic disorders, once it develops into end-stage renal disease, it is often more difficult to treat than other kidney diseases. Therefore, timely prevention and treatment is of great significance for delaying diabetic nephropathy. Diabetic nephropathy is one of the most common chronic microvascular complications of diabetes. The pathological manifestations of the kidneys are chara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P29/00A61P13/12A61P3/10A61P9/10A61K31/519
CPCA61K31/519A61K36/236A61K36/481A61K36/537A61P3/10A61P9/10A61P13/12A61P29/00A61K2300/00
Inventor 赵增超李佐君任维军
Owner 山东科迪臻药业有限公司
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