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Rapid-release fructose diphosphate sodium tablet and preparation method thereof

A sodium diphosphate tablet and sodium fructose diphosphate technology, which is applied in the field of solid oral preparations, can solve the problems of whether the active ingredients can be released in time and completely, and achieve the effects of improving reliability and effectiveness, rapid release, and simple preparation

Inactive Publication Date: 2011-05-04
SHANGHAI TIANLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As is well known, both tablets and capsules have the problem of timely and complete release of the active ingredient

Method used

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  • Rapid-release fructose diphosphate sodium tablet and preparation method thereof
  • Rapid-release fructose diphosphate sodium tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] prescription:

[0040] Sodium fructose diphosphate 300mg

[0041] Calcium hydrogen phosphate 200mg

[0042] Croscarmell Starch Sodium 70mg

[0043] Poloxamer 188 40mg

[0044] Micronized silica gel 20mg

[0045] Preparation: Grind the above excipients and pass through a 60-mesh sieve; fully mix sodium fructose diphosphate and poloxamer 188, sieve and mix with calcium hydrogen phosphate and cross-linked sodium carboxymethyl starch, and prepare by dry granulation Granules, including pressing into large tablets, then crushing, passing through a 14-mesh sieve for granulation, adding micro-powder silica gel to press into tablets, and then obtain.

Embodiment 2

[0047] prescription:

[0048] Sodium fructose diphosphate 300mg

[0049] Compressible starch 200mg

[0050] Low-substituted hypromellose 70mg

[0051] Sodium Lauryl Sulfate 40mg

[0052] Micronized silica gel 20mg

[0053] Preparation: Grind the above-mentioned auxiliary materials and pass through a 60-mesh sieve; fully mix sodium fructose diphosphate and sodium dodecylsulfonate, sieve and mix with compressible starch and low-substituted hypromellose, add micropowder silica gel to press Slices, ready to serve.

Embodiment 3

[0055] prescription:

[0056] Sodium fructose diphosphate 300mg

[0057] Lactose 200mg

[0058] Cross-linked polyvinylpyrrolidone 70mg

[0059] Sodium Alginate 40mg

[0060] Micronized silica gel 20mg

[0061] Preparation: Grind the above-mentioned auxiliary materials and pass through a 60-mesh sieve; fully mix sodium fructose diphosphate and sodium alginate, sieve and mix with lactose and cross-linked polyvinylpyrrolidone, add micronized silica gel to press into tablets, and obtain the product.

[0062] Implement effect test;

[0063] The tablet prepared by above-mentioned comparative example and embodiment is carried out dissolution test respectively, and the results are as follows:

[0064]

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Abstract

The invention provides a rapid-release fructose diphosphate sodium tablet, which comprises the active constituent of fructose diphosphate sodium as well as one or more of a filler, a disintegrating agent, a binder, a lubricant, a flow aid, a flavoring agent, a smelling agent and a coloring agent, and further comprises a release accelerator for accelerating the release of the active constituent. The release accelerator can be selected from the following substances of lauryl sodium sulfate, poloxamer, tweens, brominated hexadecane trimethylamine, sodium lauryl sulfate, stearyl alcohol sulfonate sodium, polyoxyethylene higher fatty alcohol, sucrose ester, sorbitol fatty ester, soyabean lecithin, alginic acid, sodium alginate and colloidal magnesium aluminum silicate, and the dosage of the release accelerator accounts for 0.1-5% of the total weight of the tablet.

Description

technical field [0001] The present invention relates to a solid oral preparation for the treatment of cardiovascular diseases, such as myocarditis, cardiomyopathy, ischemic encephalopathy and other diseases, in particular to a fast-release sodium fructose diphosphate tablet, and the present invention also relates to the tablet The preparation method of the agent. Background technique [0002] Fructose 1,6 Diphosphate Sodium (FDP) is a cardiovascular disease treatment drug, mainly used for coronary heart disease, angina pectoris, acute myocardial infarction, heart failure, arrhythmia, hemorrhagic, toxic and cardiogenic shock , Adjuvant treatment of acute adult respiratory distress syndrome and other diseases. [0003] FDP is an important intermediate metabolite in the process of glucose glycolysis in the body. It exists in the cells of the human body and all other higher animals and plants. It can regulate the activity of several enzymes in glucose metabolism, restore and im...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/70A61K47/02A61K47/18A61K47/20A61K47/24A61K47/34A61K47/36A61P9/10A61K47/10A61K47/26
Inventor 丁杰王小蕾
Owner SHANGHAI TIANLONG PHARMA
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