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Compound neomycin sulfate soluble powder and production method thereof

A technology of neomycin sulfate and its production method, which can be used in powder delivery, pharmaceutical formulations, organic active ingredients, etc. It can solve the problems of short maintenance time, general curative effect, and difficult absorption, and achieve low toxicity, good oral absorption, and increased absorption. Effect

Inactive Publication Date: 2012-04-04
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neomycin sulfate is not easy to absorb when taken orally alone, and the concentration in the intestine is high. After oral administration, only 3% of the total amount is excreted from the urine after being absorbed, and the rest is directly excreted. Therefore, the curative effect of controlling enteritis and diarrhea is general, and the maintenance time is short

Method used

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  • Compound neomycin sulfate soluble powder and production method thereof
  • Compound neomycin sulfate soluble powder and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Mix (1) 5 kg of neomycin sulfate, (2) 2 kg of doxycycline hydrochloride, (3) 2 kg of trimethyl benzalkonium pyrimidine, (4) 1 kg of atropine sulfate and 10 kg (7) anhydrous glucose for 5 minutes, and then Add (5) 2 kg of Astragalus extract, (6) 1 kg of fine silica powder and the remaining 77 kg (7) of anhydrous glucose for mixing for 10 minutes to obtain the final product. The content of neomycin sulfate in the final product is 5%; the pH of the aqueous solution is 4.4; and the moisture content is 7.6%.

Embodiment 2

[0017] Mix (1) 8kg of neomycin sulfate, (2) 5kg of doxycycline hydrochloride, (3) 3kg of trimethylbenzylammonium pyrimidine, (4) 3kg of atropine sulfate and 19kg (7) of anhydrous glucose for 5 minutes. Add (5) 2kg of Astragalus extract, (6) 2kg of fine silica powder and the remaining 58kg (7) of anhydrous dextrose for mixing for 10 minutes to obtain the final product. The content of neomycin sulfate in the final product is 8%; the pH of the aqueous solution is 4.5; and the moisture content is 8.3%.

Embodiment 3

[0019] Mix (1) 10kg of neomycin sulfate, (2) 8kg of doxycycline hydrochloride, (3) 6kg of trimethylbenzylammonium pyrimidine, (4) 4kg of atropine sulfate and 28kg (7) anhydrous glucose for 5 minutes, then Add (5) 4kg of Astragalus extract, (6) 4kg of fine silica powder and the remaining 36kg (7) of anhydrous glucose for mixing for 10 minutes to obtain the final product. The content of neomycin sulfate in the final product is 10%; the pH of the aqueous solution is 4.6; and the moisture content is 8.7%.

[0020] In the foregoing Examples 1 to 3, the neomycin sulfate, doxycycline hydrochloride, trimethylbenzylammonium pyrimidine, atropine sulfate, astragalus extract, fine silica powder and anhydrous glucose are all commercially available general products .

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Abstract

The invention provides compound neomycin sulfate soluble powder and a production method thereof. The soluble powder is prepared by mixing neomycin sulfate, doxycycline hydrochloride, trimethoprim, atropine sulfate, astragalus root extract, silicon dioxide fine powder and anhydrous dextrose. The obtained neomycin sulfate soluble powder is compounded by using multiple components, and has the effects of greatly reducing diarrhea of livestock and poultry animals, quickly recovering health status and the like.

Description

technical field [0001] The invention relates to the technical field of animal health medicines, in particular to a compound neomycin sulfate soluble powder and a production method thereof. Background technique [0002] The antibacterial spectrum of neomycin sulfate is similar to that of kanamycin sulfate, and it mainly acts on most Gram-negative bacilli, such as Escherichia coli, Proteus, Salmonella, and Pasteurella multocida. The curative effect on enteritis caused by the above diseases is particularly significant. Oral administration can be used to treat intestinal infections, such as chicken colibacillosis and pullorum. However, neomycin sulfate is not easy to absorb when taken orally alone, and the concentration in the intestine is high. After oral administration, only 3% of the total amount is excreted from the urine after being absorbed, and the rest is directly excreted. Therefore, the curative effect of controlling enteritis and diarrhea is general, and the maintenan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7036A61K9/14A61K47/04A61K47/26A61P1/12A61P31/04A61K36/481A61K31/46A61K31/505A61K31/65
Inventor 周玲
Owner WUXI ZHENGDA POULTRY
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