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Metal implant with bioactive surface modification and preparation method thereof

A surface modification and biological activity technology, applied in the field of biomedicine, can solve the problems such as failure to achieve growth factor embedding and controlled release, cumbersome surface modification method of chitosan, unsuitable for industrial production, etc. Improve biocompatibility and meet environmental requirements

Inactive Publication Date: 2011-04-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing chitosan surface modification method is relatively cumbersome and not suitable for industrial production. In addition, it has failed to realize the embedding and controlled release of functional substances such as growth factors, and does not have the function of stimulating the healing of fractures and promoting the growth of bone cells.

Method used

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  • Metal implant with bioactive surface modification and preparation method thereof
  • Metal implant with bioactive surface modification and preparation method thereof
  • Metal implant with bioactive surface modification and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Use 400# and 600# metallographic sandpaper to polish the pure metal titanium dental implant (circular metal titanium sheet with a diameter of 9 mm and a thickness of 1 mm). Put the polished titanium sheet into distilled water, acetone, 70% ethanol, and distilled water in turn, and use ultrasonic cleaning for 20, 15, 20, and 20 minutes respectively. Vacuum dry. Dissolve sulfonated chitosan in deionized water containing 0.1MNaCl at room temperature to make a sulfonated chitosan solution with a concentration of 2mg / ml; dissolve chitosan in 1% (v / v) containing 0.1MNaCl In acetic acid, make a chitosan solution with a concentration of 2mg / ml; PEI is dissolved in deionized water containing 0.1MNaCl, and make a PEI solution with a concentration of 2mg / ml; 5mg / ml bovine serum albumin (BSA) with 0.1MNaCl solution. Soak the treated titanium sheet in PEI solution for 20 minutes, wash it twice in deionized water for 2 minutes each, and dry it with cold air to obtain a pretreatment l...

Embodiment 2

[0041] Use 400# and 600# metallographic sandpaper to polish the nickel-titanium alloy medical implant (circular metal sheet with a diameter of 9 mm and a thickness of 1 mm) in sequence. Put the polished nickel-titanium alloy sheet into distilled water, acetone, 70% ethanol, and distilled water in sequence, and clean it with ultrasonic waves for 20, 15, and 20 minutes respectively. Vacuum dry. At room temperature, carboxymethyl chitosan is dissolved in deionized water containing 0.1MNaCl to make a concentration of carboxymethyl chitosan solution of 2mg / ml; chitosan is dissolved in 1% (v / ml) containing 0.1MNaCl v) In acetic acid, the concentration is 2mg / ml chitosan solution; PEI is dissolved in deionized water containing 0.1MNaCl, and the concentration is 2mg / mlPEI solution; 5mg / ml bovine serum albumin (BSA) solution of 0.1MNaCl . Soak the treated nickel-titanium alloy sheet in PEI solution for 20 minutes, wash it twice in deionized water for 2 minutes each, and dry it with c...

Embodiment 3

[0043] Use 400# and 600# metallographic sandpaper to polish the stainless steel medical implant (circular metal sheet with a diameter of 9 mm and a thickness of 1 mm). Put the polished stainless steel sheet into distilled water, acetone, 70% ethanol, and distilled water in sequence, and clean it with ultrasonic waves for 20, 15, and 20 minutes, respectively. Vacuum dry. Dissolve carboxymethyl chitosan and chitosan quaternary ammonium salt in deionized water containing 0.1M NaCl respectively at room temperature to form two solutions with a concentration of 2 mg / ml; PEI is dissolved in deionized water containing 0.1M NaCl , Dubbed PEI solution with a concentration of 2mg / ml; 5mg / ml bovine serum albumin (BSA) solution of 0.1M NaCl. Soak the treated stainless steel sheet in PEI solution for 20 minutes, wash it twice in deionized water for 2 minutes each, and dry it with cold air to obtain a pretreatment layer with stable positive charge. Then soak the stainless steel sheet with ...

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Abstract

The invention discloses a bioactive surface modification method of a metal implant. In the method, chitosan and derivatives thereof with opposite charges are alternately assembled on the surface of the metal implant by a layered self assembly mode, wherein the thickness of a deposition film layer is less than 100nm. A preparation method of the metal implant comprises the following steps of: (1) placing the metal implant subjected to surface polishing and cleaning in a PEI(Polyetherimide) dilute solution and self-assembling to form a pretreatment layer with positive charges; (2) sequentially soaking the metal implant in chitosan and chitosan derivative dilute solutions with positive charges to obtain a multilayer self-assembling surface coating; and (3) continuously carrying out alternate assembly on effective active substances of growth factors, and the like and the chitosan derivatives with opposite charges on the surface of the self-assembling coating to obtain a composite film carrying active ingredients, wherein the active substances have slow release effect in the composite film. The coating of the invention improves the biocompatibility of the metal implant, and the preparation method is simple and accords with environmentally-friendly requirement.

Description

technical field [0001] The invention relates to a metal biomedical implant and a preparation method thereof, in particular to a bioactive surface-modified metal implant and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] Due to their excellent biomechanical properties, biomedical metal materials are widely used in clinical hard tissue repair and replacement materials. In a physiological environment, toxic reactions, side effects and functional failures may occur due to physiological corrosion of metal materials. In order to improve the corrosion resistance, wear resistance and more important biocompatibility of metals and their alloy materials, it is often necessary to Surface bioactive modification and modification are carried out to make the contact between the metal surface and human tissue reach or approach the physiological state, that is, biological combination. [0003] There are many treatment technologies for surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/04A61L27/06A61L27/54A61L31/12A61L31/16A61L31/02
Inventor 王小慧李栋孙润仓
Owner SOUTH CHINA UNIV OF TECH
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