Polycaprolactone (PCL) and polylactic acid (PLA) human body absorbable vascular stent and preparation method thereof

Abstract

The invention relates to a polycaprolactone (PCL) and polylactic acid (PLA) human body absorbable vascular stent and a preparation method thereof. The two ends of a degradable vascular stent prepared from PCL and PLA fibers are provided with tracing joints with X-ray dominance. The preparation method comprises the following steps of: preparing PCL and PLA as-spun fibers by a melt blended spinning method and stretching the PCL and PLA as-spun fibers; and weaving the stretched fibers on a self-made vascular stent die, connecting the heads of the fibers by using barium sulfate and PCL hollow tubular joints, and performing heat setting on the stent to obtain the vascular stent of which the two ends have the X-ray dominance. The material of the stent has high compatibility with a human body, the prepared stent has stable performance, and the barium sulfate tubular joints at the two ends of the stent have the function of in-vivo X-ray tracing targets, so the stent is convenient to observe and research after being implanted into the human body; and the preparation method is simple and has low cost and good application prospect.

Description

technical field [0001] The invention belongs to the field of human body absorbable vascular stent and preparation thereof, in particular to a PCL and PLA human body absorbable vascular stent and a preparation method thereof. Background technique [0002] With the improvement of human living standards and changes in diet structure, the incidence of cardiovascular diseases is increasing. Coronary heart disease caused by cardiovascular stenosis has become a major disease that endangers people's health. Since the beginning of the 20th century, people have made unremitting efforts to treat coronary heart disease. From the initial relief of symptoms and relief of pain, it has gradually developed to radical surgery and interventional therapy with balloon stents. In recent years, surgical replacement or bypass grafting is the main means of treating coronary artery or peripheral atherosclerotic disease, and coronary artery stent implantation has been widely used in the treatment of ...

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Problems solved by technology

However, the blending method easily leads to changes in the product, and it is easy to form an ionic developing resin, which is easy to absorb water and cause the loss of developing atoms [Xia Weijuan et al. A preparation method of developing polyurethane (200810223421.5)]

W.A.Chan added barium sulfate into polylactide as a contrast agent to prepare a stent with visual effects. After the stent is implanted in the body, it is easy to be tracked, but the mechanical properties of the stent prepared are lower than The mechanical properties of the stent prepared without adding contrast agent are lower [W.A.Chan, eal. Effect of radio-opaque filler on biodegradable stent Properties. Journal of Biomedical Materials Research Part A, 2005, 6(6): 47-52]

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