Compound fluorouracil liposome oral liquid and preparation method thereof
A technology for fluorouracil and oral solution, which is applied in the field of compound fluorouracil liposome oral solution and its preparation, can solve the problems of product stability attenuation, unsatisfactory effect, long process and the like, achieve stable product quality, avoid adverse reactions, and avoid The effect of the recycling process
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Embodiment 1
[0020] Process prescription: fluorouracil (5-FU) 1000g, ginseng polysaccharide 2000g, distearoylphosphatidylcholine 5000g, Tween-80 3500g, oleic acid 2500g, cholesterol 3000g, povidone K30 (PVP) 2500g, butyl hydroxyl Toluene 250g, glycine 500g, add water for injection to a total volume of 250L, weigh distearoylphosphatidylcholine and 36L water for injection (80-85°C) into the colloid mill together, circulate for 10 minutes, then switch to heating In the reaction kettle, add Tween-80 and melted oleic acid and cholesterol, stir at 80°C for 20 minutes, transfer to the colloid mill, add antioxidant butyl hydroxytoluene and phosphate buffer (pH6.7 -6.8) Circulate for 15 minutes to form solution I, then transfer to the reaction kettle and keep warm at 80°C. Then weigh the PVP and 5-FU of the formula, dissolve PVP in 100L, 80°C water for injection, then add 5-FU, heat to 80°C, and then slowly add it to I under stirring to form solution II , after the dropwise addition, add the prepa...
Embodiment 2
[0022] (a) Process prescription:
[0023] Fluorouracil 0.41g, Ginseng Polysaccharide 0.66g, Distearoyl Phosphatidylcholine 1.65g, Tween-801.115g, Oleic Acid 0.825g, Cholesterol 0.66g, Povidone K300.825g, Butylated Hydroxytoluene 0.0825g, Glycine 0.0825g, water for injection to 100ml.
[0024] (b) Weigh distearoylphosphatidylcholine and 25ml of water for injection with a water temperature of 85°C and add them to the colloid mill. After circulating for 20 minutes, transfer them to the heating reaction kettle and set aside;
[0025] (c) heating and melting oleic acid and cholesterol, and stirring for 20 minutes for subsequent use;
[0026] (d) Add Tween-80 and melted oleic acid and cholesterol into the reaction kettle, stir at 85°C for 20 minutes, and transfer to the colloid mill;
[0027] (e) Add butylated hydroxytoluene to the colloid mill, add a phosphate buffer with a pH value of 8.0, and circulate for 15 minutes to form a solution I, then transfer it to the reaction kettle...
Embodiment 3
[0039] After making product according to above-mentioned embodiment 1,2 and comparative example 1,2, under the same condition, immediately measure the encapsulation efficiency of prepared liposome according to Sephadex method, (assay method and calculation method refer to ( Zhang Qi, Deng Yingjie. Freeze-thaw method to prepare 5-FU liposomes [J]. Shenyang Pharmaceutical University) method described in the literature. The experimental results are shown in Table 1.
[0040] Table 1:
[0041]
[0042] Experimental results show that the product provided by the invention has a better encapsulation effect.
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