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Application of macleaya cordata extractive in veterinary drugs for economic animals

A technology of Boluohui extract and veterinary medicine, which is applied in the application field of Boluohui extract in economic animal veterinary medicine, can solve the problems of economic loss in livestock and poultry breeding industry, and achieve the effect of improving feed conversion rate

Active Publication Date: 2011-02-16
MICOLTA BIORESOURCE INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cause serious economic losses to the livestock and poultry industry

Method used

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  • Application of macleaya cordata extractive in veterinary drugs for economic animals
  • Application of macleaya cordata extractive in veterinary drugs for economic animals
  • Application of macleaya cordata extractive in veterinary drugs for economic animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 The preparation method of Boluohui extract

[0017] Take Boluo fruit pods, extract with 20 times the amount of 0.5% sulfuric acid aqueous solution, then adjust the pH to 8-10 with alkali, separate the precipitate, then extract with 90% ethanol, filter part of the concentrated extract, add concentrated sulfuric acid to precipitate A large amount of orange-red precipitates, after drying, obtain the Boluohui extract. The total biological content measured by HPLC is about 66.4% (total the content of prosanginarine and chelerythrine, the same below), wherein sanguinarine is about 66.4%. For 46.4%, chelerythrine is about 20%.

Embodiment 2

[0018] Example 2 Preparation of Boluohui Extract Premix

[0019] Weigh 100 g of the Boluohui extract prepared by the method in Example 1, use a medicine pulverizer to pulverize, pass through a 120-mesh sieve, and set aside; then weigh 3900 g of medicinal starch. Thoroughly mix the Boluohui extract and medicinal starch with a small mixer for 15 minutes, check that the coefficient of variation is <0.5, and obtain 4000 grams of Boluohui extract premix.

Embodiment 3

[0020] Example 3 In vitro inhibition test of Boluohui extract on common pathogenic bacteria of livestock and poultry

[0021] Select Boluohui extract for use, and measure its content In order to carry out experimental research, the solution prepared by the Boluohui extract prepared in Example 1 is respectively common to livestock and poultry such as Haemophilus, Listeria, Pasteurella, and Streptococcus. In vitro antibacterial test for animal pathogenic bacteria. According to the aseptic operation procedure, under aseptic conditions, dump the medium plate corresponding to the corresponding strain, and apply the corresponding strain inoculum on it. Paper and tablet are tightly bonded. At the same time, a filter paper soaked in aureomycin was used as a control. Three copies of each sample were made, and the results were averaged. Invert culture at 37°C, observe the antibacterial effect at 24 hours, measure the diameter of the antibacterial zone, and judge the sensitivity.

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PUM

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Abstract

The invention relates to the application of a macleaya cordata extractive in veterinary drugs for economic animals, in particular to the application of the macleaya cordata extractive in the preparation of veterinary drugs with favorable inhibition effect and killing effect on common livestock and poultry diseases, such as protoblem listeria monocytogenes, haemophilus and pasteurella.

Description

Technical field: [0001] The present invention relates to the feed that the extract obtained from the plant Macleaya cordata (Willd) R.Br. containing benzylisoquinoline alkaloid (Benzylisoquinoline Alkaloid) can promote economic animal growth and improve feed conversion rate Applications in pharmaceutical additives and veterinary medicine. The extract mainly contains benzylisoquinoline total alkaloids, including sanguinarine, chelerythrine, protopine, allocryptine, dihydrosanguinarine, dihydroallocryptine and the like. Background technique: [0002] For a long time, due to the widespread use of growth-promoting health care agents such as antibiotics, chemically synthesized drugs, and hormones in animal feed and veterinary medicine, these additives have brought many harms to humans while promoting the development of animal husbandry. The disadvantages of the abuse of antibiotics are becoming more and more prominent. The main manifestations are: endogenous infection and super...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/12A61K36/66A61P31/04A61K127/00A61K131/00
Inventor 曾建国饶华蔡鹏
Owner MICOLTA BIORESOURCE INC LTD
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