Artificial propagation technology of SPF experimental hare

Abstract

The invention relates to the artificial propagation technology of SPF experimental hare, which comprises elements, such as breeding shed layout design, artificial insemination, semen collection and detection screening, inheritance purity family control technology, female hare aphrodisiac, concentrated breeding, full-in full-out feeding and the like; the hare shed layout is microcommunity and large scale; the semen collection and detection screening technology is used for preparing a semen product through processing semen by artificial collection technology training, quality detection, dilution with diluent and the like; the concentrated inheritance purity family control technology is used for accurately guiding works of breeding and matching by means of breeding software and field breeding family records to ensure that the inheritance background of each hare is clear so as to avoid inbreeding; the female hare aphrodisiac technology is used for making the female heat and ovulate in the same time through biology treatment method, hormone treatment method and environment stimulation method; the concentrated breeding technology refers to concentrated matching, concentrated farrowing, concentrated breeding and concentrated slaughtering on the basis of concentrated reproduction; and the full-in full-out technology refers to clearing, sterilizing and cleansing hare sheds regularly based on the concentrated breeding technology and the layout design of the hare shed to improve the sanitary level of the hare sheds; and by the invention, direct contact between the male hare and the female hare is avoided so as to reduce opportunity of pathophoresis and injury.

Description

technical field [0001] The invention relates to a breeding technology for SPF level experimental rabbits, in particular to an artificial breeding technology system for high-efficiency breeding of SPF level experimental rabbit seeds. Background technique [0002] Experimental animals are the supporting conditions for modern life science, medicine and drug research, and promote the development of life science and medicine. Experimental rabbits are widely used in immunology research, drug identification, ophthalmology research, skin sensitivity research, cardiovascular and coronary heart disease research and other fields. However, because rabbits enter the SPF barrier environment, the production efficiency is low and the pedigree control is chaotic, which cannot meet the needs of SPF-level experimental rabbits in various scientific research fields in my country, as long as the following problems exist: [0003] (1) The traditional SPF level experimental rabbit has too many see...

AI Technical Summary

Problems solved by technology

However, because rabbits enter the SPF barrier environment, the production efficiency is low and the pedigree control is chaotic, which cannot meet the needs of SPF-level experimental rabbits in various scientific research fields in my country, as long as the following problems exist:

[0003] (1) There are too many seeds in the traditional SPF level experimental rabbits, which refer to the breeding mode of small rats, and the failure is caused by the loss of genetic purity.

Stable genetic purity and clear origin of blood are the necessary conditions for experimental animal seeds. Because my country lacks the technology of breeding rabbits with SPF grade seed, we simply borrow the breeding method of small rats, without strictly establishing family lines, not strictly avoiding inbreeding, and without strict breeding. Subsequent breeding, resulting in the confusion of the genetic background of the strain, the decline of the variety, and the loss of the value of the seed;

[0004] (2) SPF rabbits have not achieved the same high-efficiency breeding as ordinary rabbits, resulting in high cost and loss of marketing value: because SPF rabbits are in a barrier environment, subject to many conditions, all have not implemented high-efficiency breeding techniques such as artificial insemination, and still adopt The natural mating method leads to low production efficiency, high labor and feeding costs, and loses the promotion value of the market;

[0005] (3) Adopting the traditional natural mating method greatly increases the chance of rabbits spreading diseases and injuries, reduces the qualified rate of products, and increases the loss of breeding rabbits: SPF experimental rabbits require rabbits to be absolutely healthy and completely avoid the chances of disease transmission and injuries , but natural reproduction must require male rabbits and female rabbits to achieve direct mating, resulting in some unhealthy breeding male rabbits leading to the spread of diseases, some causing mutual damage and other problems, which seriously threaten the quality and safety of SPF seeds and experimental rabbit products

[0006] (4) The traditional breeding mode cannot achieve "all in, all out, clean environment": daily breeding, calving, weaning, fattening and other work, resulting in there are always rabbits in the rabbit house, and it is impossible to regularly vacate the rabbit house for cleaning and disinfection, resulting in Long-term accumulation of pathogenic microorganisms such as fungi, parasites, Pasteurella, and Staphylococcus

Disinfection can only kill some microorganisms, the transmission route cannot be cut off, the pathogens will continue to multiply at any time, and the whole environment will always be in a polluted state, which makes it difficult to improve the health level of the rabbit group, and cannot produce qualified SPF level experimental rabbits

[0007] (5) The traditional breeding mode is not conducive to the process and specialization of feeding and management work: because the physiological stages of each breeding rabbit are inconsistent every day, some give birth, some are mated, some are weaned, etc., the breeder must be at the same time every day. It is impossible to realize the specificity and regularity of the work of each link, and it is impossible to establish a perfect standardized process

[0008] (6) The traditional breeding mode cannot achieve accurate statistics, scientific supervision, and continuous improvement of production levels: the status of each female rabbit is inconsistent every day, and batch statistical analysis cannot be performed

Ultimately, the production data is confused, the indicators are vague, and it is impossible to summarize and analyze, and the production level cannot be targeted to improve

[0009] (7) The traditional breeding mode raises too many male rabbits, which increases the pressure on environmental control: the SPF barrier environment is a highly clean environment that is completely controlled by air conditioning, and has strict requirements on the content of microorganisms and the concentration of harmful gases. It is much more vigorous than other rodent experimental animals, and the environmental pressure is also much greater. Because there is no artificial insemination technology, every 6 female rabbits are matched with 1 male rabbit, and the excretion of male rabbits is greater, which aggravates the environment. pressure, increasing the quality risk of SPF experimental rabbits