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Fructose combination medicament

A composition and fructose technology, applied in the directions of drug combinations, non-active components of polymer compounds, pharmaceutical formulations, etc., can solve the problems of allergy, injection pain, fever caused by drugs, etc., and achieve the effect of reducing allergic and heat-induced adverse reactions and eliminating

Inactive Publication Date: 2010-12-29
吴赣英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But fructose and fructose diphosphate sodium preparation thereof of prior art, oral large-dose fructose can cause abdominal pain, diarrhea, and intravenous injection can cause lactic acidosis and excessive uric acid in blood occasionally death takes place, also has anaphylaxis, injection pain, drug-induced Adverse reactions such as fever

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The fructose combination medicine provided by the invention is composed of the following medicinal ingredients in parts by weight:

[0021] Fructose 3.75

[0022] Composition of vitamin C and glutathione weight ratio 1:1 0.01

[0023] Edetate disodium 0.00015

[0024] Or replace fructose with sodium fructose diphosphate, and the parts by weight are calculated in parts by weight of fructose.

[0025] The present invention also provides a method for preparing the above-mentioned combination medicine, the steps are as follows:

[0026] (1) get the 0.9% sodium chloride solution that the weight is 15-50 times of described fructose weight, under the agitation of 80-100 rev / min rotating speed, add respectively and put the described amount of fructose or sodium fructose diphosphate respectively 1. The composition of vitamin C and glutathione with a weight ratio of 1:1 and edetate disodium are completely dissolved to obtain a fructose combined drug solution or a fructose sodi...

Embodiment 2

[0033] The fructose combination medicine provided by the invention is composed of the following medicinal ingredients in parts by weight:

[0034] Fructose 50

[0035] Composition of vitamin C and glutathione weight ratio 1:1 0.05

[0036] Edetate Disodium 0.00020

[0037] Or replace fructose with sodium fructose diphosphate, and the parts by weight are calculated in parts by weight of fructose.

[0038] The present invention also provides a method for preparing the above-mentioned combination medicine, the steps are as follows:

[0039] (1) get the 0.9% sodium chloride solution that the weight is 15-50 times of described fructose weight, under the agitation of 80-100 rev / min rotating speed, add respectively and put the described amount of fructose or sodium fructose diphosphate respectively 1. The composition of vitamin C and glutathione with a weight ratio of 1:1 and edetate disodium are completely dissolved to obtain a fructose combined drug solution or a fructose sodium...

Embodiment 3

[0046] The fructose combination medicine provided by the invention is composed of the following medicinal ingredients in parts by weight:

[0047] Fructose 4.10

[0048] 1:1 composition of vitamin C and glutathione weight ratio 0.037

[0049] Edetate Disodium 0.00016

[0050] Or replace fructose with sodium fructose diphosphate, and the parts by weight are calculated in parts by weight of fructose.

[0051] The present invention also provides a method for preparing the above-mentioned combination medicine, the steps are as follows:

[0052] (1) get the 0.9% sodium chloride solution that the weight is 15-50 times of described fructose weight, under the agitation of 80-100 rev / min rotating speed, add respectively and put the described amount of fructose or sodium fructose diphosphate respectively 1. The composition of vitamin C and glutathione with a weight ratio of 1:1 and edetate disodium are completely dissolved to obtain a fructose combined drug solution or a fructose sod...

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Abstract

The invention provides a fructose combination medicament or a fructose diphosphate sodiumcombination medicament. The fructose combination medicament or the fructose diphosphate sodium combination medicament is characterized by comprising the following activated pharmaceutical ingredients in part by weight: 3.75 to 50 parts of fructose, 0.01 to 0.05 part of composition consisting of vitamin C and glutathione in the weight ratio of 1:1 and 0.00015 to 0.00020 part of disodium edentate. The invention also provides a method for preparing the fructose combination medicament. The fructose combination medicament and the fructose diphosphate sodium combination medicament are mainly used for treating shock, coronary heart diseases, angina pectoris, acute myocardial infarction and ischemia myocardial, heart failure, peripheral vascular diseases, acute adult respiratory distress and anesthetic accidents, and used for parenteral nutrition therapy for critical patients, heart surgery extracorporeal circulation and the adjuvant therapy for patients requiring multiple times of blood transfusion.

Description

technical field [0001] The invention relates to fructose combined medicine and sodium fructose diphosphate combined medicine and a preparation method thereof. Background technique [0002] Fructose, molecular formula: C 6 h 12 o 6 , Structural formula: CH 2 OH(CHOH) 3 COCH 2 Oh. Containing 6 carbon atoms in fructose, it is also a monosaccharide, which is an isomer of glucose. It exists in a large amount in fruit juice and honey in a free state. Fructose can also combine with glucose to form sucrose. Fructose and its salt Sodium fructose diphosphate is used for shock, coronary heart disease, angina pectoris, acute myocardial infarction and myocardial ischemia, heart failure, peripheral vascular disease, acute adult respiratory distress, anesthesia accidents, parenteral nutrition therapy for critically ill patients, in vitro cardiac surgery Adjuvant therapy for circulation and multiple transfusion patients. Its pharmacological action is basically the same as that of gl...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61K31/7024A61K47/42A61K47/22A61P3/02A61K47/18
Inventor 刘会梅张连印蔡海德吴赣英
Owner 吴赣英
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