Method for preparing cefuroxime sodium

Abstract

The invention provides a method for preparing cefuroxime sodium. The method comprises a step of reacting cefuroxime acid with mixed sodium salt to produce the cefuroxime sodium, wherein the mixed sodium salt comprises two or three of sodium acetate, sodium lactate and sodium iso-octoate. The product prepared by the method has the advantages of uniform crystal dispersion, greatly improved fluidityand easy packaging; the solubility of the product is greatly improved, and compared with similar products prepared by the conventional methods, the dissolution time is the shortest; the method greatly shortens the time for washing, filtering and drying the product, reduces the opportunities of powder exposure and human contact, more easily controls visible foreign matters in the product and effectively reduces the number of insoluble particles in the product; because the method improves the crystal form of the product, the crystal is easy to wash and dry, the time of the product at a high temperature is shortened and the stability of the product is improved effectively. The color grade of the product is further reduced, and the product is more stable and uniform and has better performanceon indexes such as the color grade, content, impurities and the like.

Description

technical field [0001] The invention belongs to the technical field of drug synthesis, and relates to a preparation method of cephalosporin antibiotics, in particular to a preparation method of cefuroxime sodium. Background technique [0002] Cefuroxime sodium is the sodium salt of cefuroxime, which belongs to the second-generation cephalosporin antibiotics. It has a broad antibacterial spectrum and is effective against most Gram-negative bacteria, including Haemophilus influenzae, Neisseria gonorrhoeae, meningococcus, Escherichia coli, Klebsiella, Proteus mirabilis, Enterobacter, Citrobacter, Salmonella Bacteria, Shigella, and certain indole-positive denatured bacilli. The antibacterial spectrum against gram-positive bacteria is similar to that of cephalexin, mainly including staphylococci and streptococci. This product is relatively stable to β-lactamase, and its stability is no less than that of the third-generation cephalosporins. It is stable to almost all standard en...

AI Technical Summary

Problems solved by technology

[0003] However, in the existing cefuroxime sodium preparation process, sodium isooctanoate or sodium lactate is used as a raw material to form sodium salt in the product refining process, and the product has crystal stickiness during the salt formation process, resulting in difficulty in solid-liquid separation and difficult washing of the product. Dry, poorly soluble and poor crystal fluidity, and prolongs post-processing steps, increasing product exposure, making visible foreign matter and aseptic control difficult in products

Images