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Drug composition for resisting inflammation and easing pain and preparation method and application thereof

An anti-inflammatory and analgesic composition technology, applied in the field of pharmaceutical composition and its preparation, can solve the problems of increasing curative effect and so on

Active Publication Date: 2010-12-01
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no combination of the two drugs for anti-inflammatory and analgesic drugs. The combined use of the two increases the curative effect and obtains unprecedented effects

Method used

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  • Drug composition for resisting inflammation and easing pain and preparation method and application thereof
  • Drug composition for resisting inflammation and easing pain and preparation method and application thereof
  • Drug composition for resisting inflammation and easing pain and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Embodiment 1: the preparation of pharmaceutical composition tablet of the present invention

[0169] High Aconitum 95kg Geranium 98kg;

[0170] Soak the medicinal material of Aconitum aconitum with 5 times the weight of 75% ethanol for 5 hours, collect the soaking solution, continue to percolate with 75% ethanol, collect the percolation solution, combine the soaking solution and the percolation solution to obtain a mixed solution, and store the soaking solution at a temperature of 60 ° C. , concentrating the mixed solution into a concentrated solution with a relative density of 1.05-1.15, adding sodium hydroxide solution to adjust the pH to 10, standing still, centrifuging, washing the precipitate with water until neutral, and drying to obtain the Aconitum aconitum extract;

[0171] decocting the geranium medicinal material with 12 times the weight of water twice, each decocting for 3 hours, collecting and combining the extracts, and concentrating the mixed solution int...

Embodiment 2

[0173] Embodiment 2: the preparation of pharmaceutical composition capsule of the present invention

[0174] High aconitum 5kg Geranium 5kg;

[0175] Soak the high aconitum medicinal material with 10 times by weight of 75% ethanol for 18 hours, collect the soaking liquid, and continue to percolate with ethanol until there is no alkaloid reaction, collect the percolating liquid, combine the soaking liquid and the percolating liquid, and reclaim the ethanol to No alcohol smell, dissolve the residue with hydrochloric acid, centrifuge, take the supernatant, pass the supernatant through the cation exchange resin, first elute with water until the effluent is colorless, then analyze with ethanol, collect the ethanol solution, recover ethanol, the above adsorption , washing and analysis flow rates are 5 times the bed volume / hour; add ammonia solution to the recovery solution, adjust the pH to 10, extract with chloroform, combine the chloroform solution, and collect until dry to obtain...

Embodiment 3

[0178] Embodiment 3: the preparation of pharmaceutical composition powder of the present invention

[0179] High Aconitum 98kg Geranium 5kg;

[0180] Take the medicinal materials of Aconitum aconitum and Geranium, mix them and add 6 times the weight of 90% ethanol to reflux and extract once, each time for 4.5 hours, combine the extracts, filter, and concentrate the filtrate to a relative density of 1.25 at a temperature of 80°C. The concentrated solution of -1.35 is dried to obtain a dry paste, and conventional auxiliary materials are added to make a clinically or pharmaceutically acceptable powder according to a conventional process. Embodiment 4: the preparation of pharmaceutical composition soft capsule of the present invention

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Abstract

The invention discloses a drug composition for resisting inflammation and easing pain and a preparation method and application thereof. The drug composition is prepared from aconitum sinomontanum nakai and geranium wilfordii maxim as bulk drugs by the unique extraction processes of the invention. The drug composition of the invention has the following advantages: 1, the novel TCM (traditional Chinese medicine) compound for resisting inflammation and easing pain provided by the invention meets the clinical requirements; 2, according to the pharmacological research on the mutual effect and compatible formula of aconitum sinomontanum nakai and geranium wilfordii maxim, the drug composition of the invention can significantly increase the pain threshold of mice compared with single aconitum sinomontanum nakai or geranium wilfordii maxim; 3, the drug composition of the invention has obvious effects of resisting inflammation, easing pain and enhancing human immunity, thus ensuring the wide application prospect; and 4, the drug composition of the invention can be prepared into any preparation by directly feeding the bulk drug of aconitum sinomontanum nakai and geranium wilfordii maxim or by processing the extracts of aconitum sinomontanum nakai and geranium wilfordii maxim, thus meeting the requirements of mass-production.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and application, in particular to a pharmaceutical composition with anti-inflammatory and analgesic effects which uses aconite and geranium as raw materials, its preparation method and application. Background technique [0002] Aconitum aconitum is the dry root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. It is excavated in autumn, and the fibrous roots and aerial parts are removed, and the soil is washed away and dried in the sun. Distributed in Xiaowutai Mountain, Yuxian County, Hebei Province, Shanxi, counties east of Riyue Mountain in Qinghai, Shaanxi, Gansu, Hubei, Sichuan and Guizhou provinces. Its root is poisonous, used as medicine, can reduce swelling and pain, promote blood circulation and dissipate blood stasis, dispel wind, and treat fractures, rheumatic lumbago and leg pain, boils, syphilis, palpitations, stomach pain, bruise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P29/00A61P37/02
Inventor 张樱山张国霞张朋
Owner TIBET QIZHENG TIBETAN MEDICINE
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