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Lactobacillus planetarium strain LP28 and application thereof in mitigation of anaphylactic reaction

A plant lactobacillus, allergic reaction technology, applied in applications, allergic diseases, bacteria, etc., can solve problems such as unsatisfactory efficacy, difficult to effectively improve allergic reactions of the immune system, and inability to excrete intestinal mucosa from the body.

Active Publication Date: 2010-10-06
SYNBIOTECH BIOTECHNOLOGY YANGZHOU CO LTD
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Problems solved by technology

[0005] However, in order to use lactic acid bacteria to achieve the purpose of treating allergic diseases, the efficacy of the current lactic acid bacteria is not satisfactory. The acidity of the human gastric acid is as high as pH 2.5. Lactic acid bacteria are damaged or dead after being attacked by gastric acid and choline, and cannot effectively attach to the intestinal mucosa and are excreted with feces
The intestinal tract is the largest immune organ in the human body. Most of the lactic acid bacteria ingested by the human body cannot survive in the intestinal tract healthily, that is, they cannot exert the function of lactic acid bacteria, and it is difficult to effectively improve the allergic reaction caused by the immune system

Method used

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  • Lactobacillus planetarium strain LP28 and application thereof in mitigation of anaphylactic reaction
  • Lactobacillus planetarium strain LP28 and application thereof in mitigation of anaphylactic reaction
  • Lactobacillus planetarium strain LP28 and application thereof in mitigation of anaphylactic reaction

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Embodiment Construction

[0024] In order to make the above-mentioned and other purposes, features and advantages of the present invention more obvious and easy to understand, the preferred embodiments of the present invention are specifically cited below, together with the accompanying drawings, and are described in detail as follows:

[0025] After extensive and in-depth experiments, the applicant screened out a Lactobacillus plantarum strain LP28 (Lactobacillus plantarum; deposit number: CGMCC No. 3346) with excellent allergy-reducing effects. The screening process of the Lactobacillus strain is as follows:

[0026] 1. Screening of lactic acid bacteria strains from samples

[0027] The first step in the screening of lactic acid bacteria in the present invention: take dried tofu in the traditional market as a source sample for screening of lactic acid bacteria. The samples were inoculated in 10wt% skimmed milk powder culture solution, and the enrichment culture was carried out at 37°C for 16 to 20 h...

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Abstract

The invention relates to a Lactobacillus planetarium strain LP28, which is preserved in China General Microbiological Culture Collection Center (CGMCC). The preservation number of the Lactobacillus planetarium strain LP28 is CGMCC No.3346. The Lactobacillus planetarium strain or metabolite thereof has excellent capability of mitigating an anaphylactic reaction and can be widely used for preparing food compounds or medical pharmaceutical compounds.

Description

technical field [0001] The present invention relates to a lactobacillus strain capable of alleviating allergic reactions. Background technique [0002] Allergic reaction refers to the strong reaction of the immune system to some non-invasive foreign substances. In recent decades, the number of patients with allergic diseases such as bronchial asthma, allergic rhinitis and atopic dermatitis has increased dramatically. Human immune center cells T lymphocytes can be divided into two types according to the different cytokines secreted. The first type T lymphocytes (Th1) mainly secrete interferon γ (Interferon-γ, IFN-γ), and the second type T lymphocytes (Th2) mainly secrete interleukin-4 (Interleukin-4, IL-4), interleukin-5 (Interleukin-5, IL-5) and other cytokines; however, type 1 and type 2 T lymphocytes There is a dynamic balance between them. If the effect of type 1 T lymphocytes is weak, it will easily cause allergic reactions in the human body. At present, most of the tr...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/74A61P37/08A23L1/30A23C9/13C12R1/25A23L33/135A61K35/747
Inventor 徐添根蔡政志朱明财柯博强张忆如
Owner SYNBIOTECH BIOTECHNOLOGY YANGZHOU CO LTD
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