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Dietary supplements containing natural ingredients

A technology for food additives and additives, applied in the field of food additives, can solve the problems of high cost and impractical sources of flavonoids.

Inactive Publication Date: 2013-02-20
MELALEUCA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The result is that many sources of flavonoids are impractical, too expensive, or both based on flavonoids available on a daily basis

Method used

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  • Dietary supplements containing natural ingredients
  • Dietary supplements containing natural ingredients
  • Dietary supplements containing natural ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1 - Evaluation of platelet inhibitory activity of food additives

[0094] Using Folts, J., Circular Magazine (Supplement 4) Ten anesthetized dogs with coronary artery stenosis and medial injury were established for evaluation using the Folts model method disclosed in , 83:3-14 (1991). Blood pressure and coronary blood flow were continuously monitored throughout the experiment. Such as figure 2 As indicated, at administration of PROVEXCV TM Previously, 10 dogs exhibited 8 ± 3 episodes of acute platelet thrombosis with figure 2 CFR's in similar CFR's. All data representing strip charts are based on the same level, with 12 squares each representing 10 minutes. Give each dog 10 mg / kg of PROVEXCV via gastric tube TM . Such as image 3 Shown, in 9 out of 10 dogs intragastric administration of 10 mg / kg PROVEXCV was observed within 174 ± 24 minutes TM CFR's can be eliminated. At 10 mg / kg PROVEXCV TM After 3 hours, the number of CFR's present in the tenth...

Embodiment 2

[0097] Example 2 - Evaluation of the Effects of Food Additives on the Oxidation of LDL Cholesterol

[0098] As mentioned above, when LDL cholesterol is exposed to oxidative conditions, usually by observing the time at 234nm (Abs 234nm ) to measure the oxidation of low-density lipoprotein cholesterol. Determination of PROVEXCV TM and the antioxidant efficiency of other substances.

[0099] Preparation of LDL cholesterol from blood samples of volunteers. Separated LDL cholesterol was then mixed with a buffer, Vitamin E, ProVex Plus TM ( Figure 6 "orig" in ) or PROVEXCV TM ( Figure 6 “Curr” in ) mixed. ProVex Plus TM and PROVEXCV TM Experimental solutions were prepared at final concentrations of 0.5 and 1.0 mg / ml. Selected ProVex Plus TM and PROVEXCV TM The concentrations are the expected blood levels of the food additive estimated based on accepted blood absorption models. A measured amount of copper ions was added to each sample. The amount of vitamin E used c...

Embodiment 3

[0102] Example 3 - to PROVEXCV2 TM evaluation of

[0103] Evaluation of PROVEXCV2 in dogs using the Folts model TM The effect on platelet activity, and its effect in vitro was evaluated by whole blood platelet aggregation assay. Briefly, 10 mongrel adult dogs of both sexes were anesthetized and the thorax was opened in the 5th intercostal space. The left curved coronary artery was cut open, and an electromagnetic flow probe was placed around the artery to measure the blood flow of the coronary artery. At the end of the flow probe, the artery was clamped 3 times with a specific surgical forceps to injure the intima and media. A plastic ring of suitable inner diameter is placed on the outer ring of the artery to create a 70% stenosis of the inner diameter of the artery.

[0104] During the development of CFR's, blood samples were collected for in vitro whole blood platelet aggregometry. After monitoring the continuous formation of CFR's for 20 minutes, 15 mg / kg of PRO...

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PUM

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Abstract

The invention provides a dietary supplement comprising at least one flavonoid source and an enzyme, that is effective for inhibiting in vivo platelet activity and LDL cholesterol oxidation in a mammal at a dosage of about 30 mg / Kg or less. The supplement may contain flavonoid sources found in grape seed extracts, grape skin extracts, bilberry extracts, ginkgo biloba extracts or the flavonoid quercetin. The supplement may also contain fungal proteases, acid stable proteases and bromelain. The invention further provides a method for using the dietary supplement and an article of manufacture containing the supplement.

Description

[0001] This application is a divisional application of the Chinese patent application 98808675.1 with the filing date of August 5, 1998 and the title of the invention being "A Food Additive Containing Natural Components". technical field [0002] The invention relates to a food additive containing natural ingredients. Background technique [0003] Coronary heart disease, myocardial infarction, stroke and other vascular embolism diseases are the main factors that threaten health. A common feature of these diseases is atherosclerosis or narrowing of the arteries. Platelets are factors that lead to the formation and occurrence of atherosclerosis. They release growth factors, chemical polymers and other factors to accelerate the process of atherosclerosis. In addition, aggregation of platelets at or near the site of arterial injury leads to atherosclerosis formation and acute platelet thrombosis. [0004] Low-density lipoprotein (LDL) cholesterol has also been linked to athero...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/29A23L1/30A23L29/00A23L33/00A61K31/685A61K31/715A61K36/00A61K36/16A61K36/18A61K36/87A61K38/43A61P7/02A61P9/10
CPCC12Y304/00A23L1/034A23L1/3002A23L29/06A23L33/105A61P7/02A61P9/10A23V2002/00A61K31/352A61K36/16A61K36/45A61K36/87A61K38/48A61K38/4873A61K2300/00A23V2250/2116A23V2250/2106A23V2250/2122
Inventor 林恩·珀克斯
Owner MELALEUCA INC
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