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Preparation method for starch nanospheres

A nano-starch and microsphere technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of low product yield, uneven particles, long cycle, etc., and achieve easy industrialization promotion, uniform particle size distribution, and easy process control. Effect

Inactive Publication Date: 2015-07-22
INST OF CHEM CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The physical method mainly uses a ball mill or strong air flow to micronize various starches, which has disadvantages such as long cycle, large particle size, uneven particles and poor roundness.
The chemical method is mainly to hydrolyze starch under acidic or alkaline conditions. The hydrolysis process is not easy to control, accompanied by dextrin, maltose or glucose hydrolyzate, and the product yield is low.
The inverse microemulsion method has mild reaction conditions, easy control of various influencing factors, and good reaction reproducibility. It is the most commonly used method for preparing starch microspheres, but it will use toxic reagents such as toluene, chloroform or phosphorus oxychloride, which will pollute Biological properties of native starch

Method used

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  • Preparation method for starch nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of nano starch microspheres in embodiment 1, LiOH solution

[0038] (1) Add 0.1 g of corn amylose (purchased from Sigma Aldrich, molecular weight 40 to 340K) into a sample bottle containing 10 mL of 0.25 mol / L LiOH solution, and stir at a constant speed of 400 rpm under normal temperature and pressure for 30 min to form a uniform Dispersed starch suspension.

[0039] (2) Put the above-mentioned starch suspension into the freezer of the refrigerator and let it stand for 40 minutes until it freezes completely. The set temperature of the freezer of the refrigerator is -10°C.

[0040] (3) Take the pre-frozen sample obtained in step (2) out of the freezer compartment of the refrigerator, and place it on the test bench at normal temperature and pressure until it completely melts to obtain a transparent and clear starch solution.

[0041] (4) Transfer the starch solution obtained in step (3) into a cellulose acetate dialysis bag with a molecular weight cutoff ...

Embodiment 2

[0044] The preparation of nano starch microspheres in embodiment 2, KOH solution

[0045] (1) Add 0.1 g of rice amylose (purchased from Sigma Aldrich, molecular weight 40 to 340K) into a sample bottle filled with 10 mL of 0.25 mol / L KOH solution, stir magnetically at a constant speed of 400 rpm under normal temperature and pressure for 60 min to form a uniform Dispersed starch suspension.

[0046] (2) Put the above-mentioned starch suspension into the freezer of the refrigerator and let it stand for 60 minutes until it freezes completely. The set temperature of the freezer of the refrigerator is -10°C.

[0047] (3) Take the pre-frozen sample obtained in step (2) out of the freezer compartment of the refrigerator, and place it on the test bench at normal temperature and pressure until it completely melts to obtain a transparent and clear starch solution.

[0048] (4) Transfer the starch solution obtained in step (3) to a cellulose acetate dialysis bag with a molecular weight c...

Embodiment 3

[0051] The preparation of nano starch microspheres in the NaOH solution of embodiment 3,0.25mol / L

[0052] (1) Add 0.1 g of potato amylose (purchased from Sigma Aldrich, molecular weight 40 to 340K) into a sample bottle filled with 10 mL of 0.25 mol / L NaOH solution, stir at a constant speed of 400 rpm under normal temperature and pressure for 30 min to form a uniform Dispersed starch suspension.

[0053] (2) Put the above suspension in the freezer of the refrigerator and let it stand for 40mim until it freezes completely. The set temperature of the freezer of the refrigerator is -10°C.

[0054] (3) Take out the pre-frozen sample obtained in step (2) from the freezer compartment of the refrigerator, and place it on the test bench under normal temperature and pressure until it completely melts to obtain a transparent and clear starch solution.

[0055] (4) transfer the starch solution obtained in step (3) to a dialysis bag with a molecular weight cutoff of 3500, change the wate...

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Abstract

The invention discloses a preparation method for starch nanospheres. The method comprises the following steps: (1) dissolving amylase in an alkaline solution, and stirring to obtain suspension; (2) completely freezing the suspension obtained in the step (1); (3) thawing a product obtained in the step (2), and obtaining a starch solution; (4) dialyzing the starch solution obtained in the step (3), and obtaining starch dispersion liquid; (5) filtering the starch dispersion liquid obtained in the step (4), and drying to obtain the starch nanospheres. The preparation method is energy-saving, environment-friendly and simple to operate, and a process is easy to control; the preparation method only adopts a general chemical reagent and simple experimental equipment, can realize large-scale production and is easy for industrialized promotion; the starch nanospheres prepared with the method are high in purity, and the starch structure is not changed; the starch nanospheres prepared with the method are controllable in particle size and uniform in particle size distribution, can be stably dispersed in water, and can be used for biomedical carriers and food additives.

Description

technical field [0001] The invention relates to a preparation method of nano-starch microspheres, belonging to the field of nano-materials and nano-technology. Background technique [0002] Nanotechnology refers to the technology of observing, manipulating and processing atoms and molecules on the scale of several to hundreds of nanometers. Studies have found that many strange physical and chemical changes have taken place in matter at the nanoscale. In addition to changes in optical, electrical, thermal, and magnetic properties, nanomaterials also have many new properties such as radiation, absorption, catalysis, sterilization, and adsorption, thus bringing breakthrough changes to people's lives. Nanotechnology has been applied in many fields such as electronics, materials science and biology. [0003] Starch is a polysaccharide macromolecular compound composed of glucose. It has two structures of straight chain and branched chain. It is widely found in seeds, roots and f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 刘志景康宏亮刘瑞刚黄勇
Owner INST OF CHEM CHINESE ACAD OF SCI
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