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A kind of medicine for treating lymphedema and venous edema and application thereof

A lymphedema and drug technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of poor lymphedema effect, prevent skin tissue infection, be suitable for long-term use, and reduce lymphatic The effect of edema

Inactive Publication Date: 2012-02-15
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned traditional Chinese medicine preparations are not effective in treating lymphedema
And oral administration of the above-mentioned traditional Chinese medicine preparations is prone to gastric side effects

Method used

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  • A kind of medicine for treating lymphedema and venous edema and application thereof
  • A kind of medicine for treating lymphedema and venous edema and application thereof
  • A kind of medicine for treating lymphedema and venous edema and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of drug capsules for treating lymphedema and venous edema (1)

[0030] 1. Take 30kg of Sophora Radix (Sophorae Radix is ​​purchased from Ningxia Bauhinia Pharmaceutical Co., Ltd.), 10kg of Scrophularia (Scrophulariaceae from Ningxia Bauhinia Pharmaceutical Co., Ltd.), and 10kg of Salvia Miltiorrhiza (from Yuxi Wanfang Natural Medicine Co., Ltd., Yunnan) , break the crude drugs of Sophora Radix, Scrophulariaceae, and Salvia miltiorrhiza,

[0031] 2. Soak with 10 times the volume of 80% ethanol for 30 minutes,

[0032] 3. Heating and refluxing, extracting three times, the first time is maintained for 2.5h, the second time is maintained for 2h, the third time is maintained for 1.5h, the temperature of each time is about 80 ℃,

[0033] 4. Combine the three times of extracts and concentrate under reduced pressure, and the temperature is about 50 ° C to obtain a liquid extract,

[0034] 5. Drying under reduced pressure, the temperature is controlled at 50°C,

...

Embodiment 2

[0042] Preparation of drug capsules for treating lymphedema and venous edema (2)

[0043] 1. Take 50kg of Sophora Radix (Sophorae Radix was purchased from Ningxia Bauhinia Pharmaceutical Co., Ltd.), 30kg of Scrophulariaceae (Scrophularia Radix was purchased from Ningxia Bauhinia Pharmaceutical Co., Ltd.), and 30kg of Salvia Miltiorrhiza (Radix Salviae Miltiorrhiza was purchased from Yunnan Yuxi Wanfang Natural Medicine Co., Ltd.) , break the crude drugs of Sophora Radix, Scrophulariaceae, and Salvia miltiorrhiza,

[0044] 2. Soak with 10 times the volume of 80% ethanol for 30 minutes,

[0045] 3. Heating and refluxing, extracting three times, the first time is maintained for 2.5h, the second time is maintained for 2h, the third time is maintained for 1.5h, the temperature of each time is about 80 ℃,

[0046] 4. Combine the three times of extracts and concentrate under reduced pressure, and the temperature is about 50 ° C to obtain a liquid extract,

[0047] 5. Drying under r...

Embodiment 3

[0055] Preparation of drug capsules for treating lymphedema and venous edema (3)

[0056] 1. Take 70kg of Sophora Radix (Sophorae Radix was purchased from Ningxia Bauhinia Pharmaceutical Co., Ltd.), 10kg of Scrophularia (Scrophularia Radix was purchased from Ningxia Bauhinia Pharmaceutical Co., Ltd.), 20kg of Salvia Miltiorrhiza (Radix Salviae Miltiorrhiza was purchased from Yunnan Yuxi Wanfang Natural Medicine Co., Ltd.) , break the crude drugs of Sophora Radix, Scrophulariaceae, and Salvia miltiorrhiza,

[0057] 2. Soak with 10 times the volume of 80% ethanol for 30 minutes,

[0058] 3. Heating and refluxing, extracting three times, the first time is maintained for 2.5h, the second time is maintained for 2h, the third time is maintained for 1.5h, the temperature of each time is about 80 ℃,

[0059] 4. Combine the three times of extracts and concentrate under reduced pressure, and the temperature is about 50 ° C to obtain a liquid extract,

[0060] 5. Drying under reduced p...

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Abstract

The invention relates to a medicament for treating lymphedema and venous edema. The medicament is mainly prepared from the following crude drugs in parts by weight: 20-40 parts of Sophora flavescens, 5-15 parts of Scrophulariaceae, and 5-15 parts of Salvia miltiorrhiza. The invention also discloses the use of the drug for treating lymphedema and venous edema. The invention belongs to the compound preparation of traditional Chinese medicine, and its compatibility conforms to the principle of "junchenzuoshi" of traditional Chinese medicine. It is verified by pharmacodynamic experiments that the medicine can significantly reduce lymphedema and venous edema of patients, prevent and treat skin tissue infection, skin, subcutaneous tissue hyperplasia and Complications of fibrosis. Sophora flavescens, Radix Scrophulariae and Salvia miltiorrhiza in drugs for treating lymphedema and venous edema have obvious synergistic effects, ginger can reduce the coldness of drugs, and amomum has the effect of nourishing the stomach. Therefore, the medicament of the present invention reduces the side effect of stomach discomfort while improving the curative effect. The medicine has few side effects, is suitable for long-term use, and is a safe and effective medicine for treating lymphedema.

Description

【Technical field】 [0001] The invention relates to a medicine for treating lymphedema and venous edema and its application. Specifically, Chinese patent medicines are prepared from Chinese herbal medicines. 【Background technique】 [0002] Lymphatic circulation is one of the body's physiological and functional systemic circulation. Lymph is the interstitial fluid in the intercellular spaces that flows back into the veins through the lymphatic vessels. Limb lymphedema, commonly known as elephantiasis, is caused by the obstruction of lymphatic flow and the rapid accumulation of fluid and protein in the superficial soft tissue, and the high concentration of protein causes the increase of the osmotic pressure of the limb in the tissue, thereby forming edema and causing secondary inflammation. The fascia and skin are thickened and rough, the patient's limbs are bloated, and it is inconvenient to walk. Some patients have recurrent erysipelas-like inflammatory attacks, chapped ski...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P7/10A61P9/00A61P17/00
Inventor 刘宁飞
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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