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Porous biodegradable stent and preparation method thereof

A biodegradable and biodegradable technology, applied in the field of porous biodegradable scaffolds and their preparation, can solve the problem of failing to realize commercialization, and achieve no immune rejection, tissue compatibility and blood compatibility , the effect of high porosity

Inactive Publication Date: 2013-01-16
四川合泰新光医药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The method described above is to manufacture a three-dimensional polymer scaffold that can induce cell attachment and differentiation, but there are still many problems in the method of using degradable polymers to manufacture three-dimensional scaffolds for tissue regeneration
In the field of tissue engineering, except for the small-scale PGA suture manufacturing method, it has not been commercialized

Method used

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  • Porous biodegradable stent and preparation method thereof
  • Porous biodegradable stent and preparation method thereof
  • Porous biodegradable stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1), at normal temperature, PLGA (75PLA: 25PGA) with a molecular weight of 5000 was naturally dissolved in an organic solvent prepared by dichloromethane at 20:80 by weight percentage for 2 hours to form a highly viscous solution;

[0040] (2), according to the weight ratio of sodium chloride and biodegradable polymer is 1: 5, add sodium chloride, stir evenly at normal temperature, mixing and stirring time is 1 minute, form biodegradable polymer, organic solvent and chlorine The pasty mixture of sodium chloride, then the pasty mixture is quickly filled in the plastic mold, under 345 kilopascals pressurized 10 minutes to form semi-finished product;

[0041] (3), drying the semi-finished product at 29°C for 24 hours, removing the organic solvent, and forming a molded product;

[0042] (4), carry out continuous dechlorination to molded product 30 hours with purified water, cause sodium chloride concentration to be less than 3 micrograms / ml;

[0043] (5) After removing sod...

Embodiment 2

[0046] (1), at normal temperature, the PLGA (65PLA: 35PGA) that molecular weight is 200000 is by weight percentage 30: 70 in the organic solvent that is prepared by weight percentage 50: 50 by dichloromethane and acetone naturally for 2.5 hours, forms high viscous solution;

[0047] (2), according to the weight ratio of potassium chloride and biodegradable polymer is 1: 10, add potassium chloride, stir evenly at normal temperature, mixing and stirring time is 2 minutes, form biodegradable polymer, organic solvent and chlorine A paste mixture of potassium chloride, then the paste mixture is quickly filled into a plastic mold, and pressurized at 414 kPa for 9 minutes to form a semi-finished product;

[0048] (3), dry the semi-finished product at 28°C for 30 hours, remove the organic solvent, and form a molded product;

[0049] (4), carry out continuous dechlorination of potassium to molded product for 24 hours with purified water, causing potassium chloride concentration to be ...

Embodiment 3

[0053] (1), at normal temperature, the PLGA (50PLA: 50PGA) that molecular weight is 350000 is naturally dissolved in the organic solvent prepared by acetone 3 hours by weight percentage 35: 65, forms highly viscous solution;

[0054] (2), add potassium nitrate by the weight ratio of potassium nitrate and biodegradable polymer as 1: 15, stir evenly at normal temperature, mixing and stirring time is 2 minutes, form biodegradable polymer, organic solvent and potassium nitrate Paste mixture, then the paste mixture is quickly filled in the plastic mold, pressurized at 483 kPa for 8 minutes to form a semi-finished product;

[0055] (3), dry the semi-finished product at 27°C for 35 hours, remove the organic solvent, and form a molded product;

[0056] (4), using purified water to carry out continuous denitrification of potassium for 48 hours to the molded product, resulting in a potassium nitrate concentration of less than 3 micrograms / ml;

[0057] (5) After removing potassium nitra...

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Abstract

The invention discloses a porous biodegradable stent and a preparation method thereof. The porous biodegradable stent mainly consists of a biodegradable polymer. The preparation method of the porous polymer stent comprises the following steps: dissolving the biodegradable polymer in an organic solvent; then stirring the mixture and soluble salt at normal temperature to form paste; pressurizing the paste in a die to form a semi-finished product; drying the semi-finished product; removing the organic solvent and desalting in pure water; and finally preparing the finished product by freeze drying pretreatment and freeze drying. The invention has the advantage that the porous biodegradable stent provided by the invention has the characteristics of good biodegradability, high porosity, specific pore size, high continuity, high ratio of superficial area to volume, histocompatibility, blood compatibility and the like and makes the human body have no foreign body sensation and have no immunological rejection. The invention is suitable for nose augmentation, breast augmentation, face-lifting and the like of the human body and tissue regeneration of tissue organ defect, cartilages of the human body, skeletons, liver, heart valves, ductus cysticus, alimentary canal and the like.

Description

technical field [0001] The invention relates to a porous biodegradable support and a preparation method thereof. Background technique [0002] With the development of biomaterials and tissue engineering, tissue engineering products are gradually used in the diagnosis and treatment of clinical diseases, especially in the repair and regeneration of some human organs. In the 20th century, the first generation of biomaterials and tissue engineering products using organic and inorganic medical materials have extended or improved the lives of more than 20 million people around the world. According to statistics, 1 / 5 of the elderly over 65 years old in the United States need to undergo temporary or permanent organ transplantation. The cost of human organ transplantation in the world accounts for 8% of medical expenses, and its expenditure is 350 billion U.S. dollars. It is foreseeable that with the development of science and technology, especially the progress of biotechnology, c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/16A61L27/18A61L27/22A61L27/24
Inventor 崔明杜彦军
Owner 四川合泰新光医药有限公司
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