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Application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains

A technology for neurogenic pain and acetylated glucose, which is applied in the fields of medicine, health and chemistry, and can solve problems such as being unsuitable for screening neuralgia treatment drugs.

Inactive Publication Date: 2012-05-23
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0037] Hot plate, tail flick, and writhing are classic animal models commonly used to screen acute pain analgesics, but they are not suitable for screening neuralgia drugs

Method used

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  • Application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains
  • Application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains
  • Application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0053] The specific pharmacological experiments are as follows:

[0054] 1. Test drug

[0055] Name: 7-O-β-D-acetylated glucose-coumarin (XH011)

[0056]

[0057] Appearance: white crystal

[0058] Source: Synthesized by the Biochemical Pharmacology Group of the Natural Resources Medicinal Chemistry Laboratory of Yunnan University.

[0059] Drug preparation, administration volume, and administration route: before use, add 0.2% pure aqueous solution of carboxymethylcellulose sodium to grind and suspend to the desired concentration. Rats were intragastrically administered once a day, and the administration volume was 45mg / Kg, 10mL / Kg.

[0060] 2. Comparative drugs

[0061] 1. Gabapentin, purchased from Sigma, CAS Number: 60142-96-3.

[0062] 2. Gastrodin, provided by Kunming Pharmaceutical Factory, batch number: 200610036.

[0063] Just before use, grind and suspend 0.2% sodium carboxymethylcellulose in pure aqueous solution to a concentration of 45 mg / mL.

[0064] 3. ...

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Abstract

The invention relates to application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains. The 7-O-beta-D-acetylation sugar-coumarin compounds comprise a pharmaceutically acceptable salt, ester or a solvate thereof, and the application relates to the application of the salt, the ester or the solvate in preparing medicaments for treating the chronic neuropathic pains, wherein a glycosyl part is arbitrary pyranose or furanose, the hydroxy of which is totally acetylated; a representative compound is 7-O-beta-D-acetylation glucose-coumarin; and the structural formula is disclosed in the specification. On a classical sciatic nerve chronic compression injury (CCI) model, through single intragastric administration and continuous intragastric administration for7 days, the compound shows definite treatment effect of resisting nervous pains. At a dose point appointed by an experiment, the compound can obviously improve the mechanical stimulus pain threshold,the nervous pain resistant efficacy is equivalent to that of Gabapentin which is a contrast medicament, and the duration is superior to that of the Gabapentin. Proved by research results, the compound can be used for treating the chronic neuropathic pains.

Description

technical field [0001] The present invention relates to pharmaceutical compounds in the fields of medicine, hygiene and chemistry, in particular to 7-O-β-D-acetylated sugar-coumarin compounds and pharmaceutically acceptable salts, esters and solvates thereof for the treatment of chronic neurogenic Uses for pain. Background technique [0002] According to the duration of pain, pain is clinically classified into two types: acute pain and chronic pain. These two types of pain have essential differences in the mechanism of occurrence. Acute pain is called nociceptive pain, that is, pain caused by tissue trauma. With the repair of tissue trauma, the pain stops naturally. Analgesics, such as narcotic analgesics and non-steroidal antipyretic analgesics, can be used during the onset Chronic pain is mainly neurogenic pain, its pathogenesis is complex, and it is difficult to cure it. It is a new field of basic and clinical research and drug development of pain medicine. It has risen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/195A61P25/04A61P29/00
Inventor 戴晓畅肖涵
Owner YUNNAN UNIV
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