Tamibarotene solid preparation and preparation method thereof

A technology of Tamibarotene and solid preparations, which is applied in the field of medicine, can solve problems such as the composition and preparation methods of Tamibarotene solid preparations, and achieve excellent quality results

Inactive Publication Date: 2010-09-15
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no study on the composition and preparation me

Method used

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  • Tamibarotene solid preparation and preparation method thereof
  • Tamibarotene solid preparation and preparation method thereof
  • Tamibarotene solid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Tamibarotene 1.71g, disintegrant 5.13g, filler 78.23g, lubricant 0.43g.

Embodiment 2

[0099] Tamibarotene accounts for 1.96g, disintegrant 4.36g, filler 78.66g, lubricant 0.52g.

Embodiment 3

[0101] Tamibarotene 2.56g, disintegrant 4.54g, filler 77.81g, lubricant 0.59g.

[0102] The disintegrant in the above-mentioned embodiment is a high-efficiency disintegrant.

[0103] The disintegrants of the above examples are preferably croscarmellose sodium, crospovidone, sodium carboxymethyl starch, microcrystalline cellulose, pregelatinized starch, low-substituted hydroxypropyl methylcellulose, amino acid One or several types of processing agar.

[0104] The fillers in the above examples include but are not limited to the fillers described in the prior art, especially the lubricants commonly used in solid preparations in "Pharmacy", such as talcum powder and magnesium stearate.

[0105] Lubricants in the above examples include but are not limited to lubricants described in the prior art, especially lubricants commonly used in solid preparations in Pharmaceutics, such as talcum powder and magnesium stearate.

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PUM

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Abstract

The invention discloses a tamibarotene solid preparation, which comprises tamibarotene, disintegrant, filler and lubricant. The tamibarotene solid preparation is characterized in that over 70 percent of the tamibarotene solid preparation can be dissolved in 20 minutes. Formula study experiments prove that the tamibarotene solid preparation comprises 2 to 3 weight percent of tamibarotene, 5 to 7 weight percent of disintegrant, 90 to 92 weight percent of filler and 0.5 to 0.7 weight percent of lubricant. Preferably, the tamibarotene solid preparation comprises 2.3 weight percent of tamibarotene, 5.8 weight percent of disintegrant, 91.2 weight percent of filler and 0.6 weight percent of lubricant.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a solid preparation of Tamibarotene and a preparation method thereof. [0002] The "high-efficiency disintegrant" in the present invention refers to an excipient added to the tablet to overcome the binder or the physical force required for tablet compression, and to promote the rapid disintegration of the tablet into small particles. Background technique [0003] The release and absorption of drugs in the body is the key to drug efficacy, and it is impossible to conduct in vivo tests for each batch of products, so an in vitro test method-dissolution test is produced. Dissolution rate, also known as dissolution rate, refers to the speed and degree of drug dissolution from solid preparations such as tablets, capsules, and granules under specified solvents and conditions. The process of determining the dissolution rate of solid preparations is called dissolution test, which is an ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/192A61K47/38G01N21/33A61P35/02
Inventor 顾群金治刚孙学伟徐春霞王东孙德杰
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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