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Pharmaceutical composition containing quercetin and usage thereof

A technology of quercitrin and medicine, which is applied in the field of medicine, can solve the problems of difficulty in promotion and use and high price, and achieve the effects of reducing potential safety hazards, reliable formulations, and ensuring drug safety

Active Publication Date: 2011-08-03
XIAN XINTONG PHARM RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Tamiflu and other drugs are effective in the treatment of H1N1 influenza virus, they are expensive, and it is not easy to fully promote and use them in the third world countries

Method used

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  • Pharmaceutical composition containing quercetin and usage thereof
  • Pharmaceutical composition containing quercetin and usage thereof
  • Pharmaceutical composition containing quercetin and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation and safety test of embodiment 1 quercitrin pharmaceutical preparation

[0043] 1.1 Preparation of quercitrin oral tablet

[0044] Prescription: Quercitrin 50g

[0045] Lactose 100g

[0046] Microcrystalline Cellulose 30g

[0047] Cross-linked polyvinylpyrrolidone 10g

[0048] 3% (w / v) polyvinylpyrrolidone K 30 Ethanol solution 20ml

[0049] Magnesium stearate 0.5g

[0050] Made into 1000 pieces

[0051] Concrete preparation method: take quercitrin and adjuvant of prescription quantity, fully mix it, add 3% (w / v) polyvinylpyrrolidone K 30 The ethanol solution is made into a soft material, granulated with a 20-mesh sieve, blast-dried at 45°C, granulated with a 18-mesh sieve, added with the prescribed amount of magnesium stearate, mixed evenly, pressed into tablets, and coated with a film coat.

[0052] 1.2 Preparation of quercitrin oral liquid

[0053] Prescription: Quercitrin 100g

[0054] Tween 80 20g

[0055] Sucrose 100g

[0056] Sorbic acid 10...

Embodiment 2

[0082] The pharmacodynamics test of embodiment 2 quercetin

[0083] 1. Test material

[0084] 1.1 Animals: ICR strain mice, ♀ Half and half, weight 18-22g, quality certificate: Shanyi Dongzi No. 200-006; New Zealand white rabbit, ♀ For dual use, weighing 2-2.5g, the certificate of conformity is SCXK (Shaanxi) No. 2009-001, purchased from the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0085] 1.2 Test drugs

[0086] Test drug: quercetin oral liquid prepared by the method of embodiment 1.2 (calculated as quercetin: 10mg / ml)

[0087] Positive drug: Cyclophosphamide (CTX) injection dry powder, 200mg / bottle. Shanghai Hualian Pharmaceutical Co., Ltd., batch number 091020.

[0088] Lactose erythromycin injection. Xi'an Lijun Pharmaceutical Company, batch number 20090410

[0089] Ribavirin Injection Specification: 0.1g / bottle. Zhengzhou Yonghe Pharmaceutical Co., Ltd., batch number: 0910056

[0090] Tamiflu Specification: 75mg Yichang Chang...

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Abstract

The invention provides the application of quercetin in the preparation of medicine for preventing or treating diseases caused by influenze virus, adenovirus, staphylococcus aureus and / or streptococcus hemolyticus and the like, and a pharmaceutical composition thereof. The pharmaceutical composition has the activity for resisting the influenze virus being equivalent to oseltamivir.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to quercitrin in the preparation of medicines for preventing or treating diseases caused by influenza virus, adenovirus, Staphylococcus aureus and / or hemolytic streptococcus application and its pharmaceutical composition. Background technique [0002] Quercetin is a structural analogue of quercetin, and its molecular structure is: [0003] [0004] Although there are many reports on quercetin and its derivatives, there are few studies on quercetin itself, and the research on quercetin itself basically focuses on the quality control of traditional Chinese medicine extracts. For example, Chinese Patent Application No. 99120216.3 discloses the preparation method of quercetin and its application in the prevention or treatment of depression or anxiety; [0005] Chinese patent application No. 99812942.9 discloses the method of quercetin and isoquercetin (querc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P31/04A61P31/16A61K31/7048A61P31/12
Inventor 张登科
Owner XIAN XINTONG PHARM RES CO LTD
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