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Acipimox push-pull osmotic pump controlled release tablet and preparation method thereof

A technology of osmotic pump controlled release and acyclolimus, which is applied in the field of acyclomus double-layer osmotic pump controlled release tablet and its preparation, and achieves the effect of overcoming the frequent taking and maintaining blood drug concentration

Inactive Publication Date: 2010-08-04
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And in the prior art, there is no relevant report of making acipimox into double-layer osmotic pump controlled release tablets

Method used

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  • Acipimox push-pull osmotic pump controlled release tablet and preparation method thereof
  • Acipimox push-pull osmotic pump controlled release tablet and preparation method thereof
  • Acipimox push-pull osmotic pump controlled release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Tablet prescription:

[0026] Drug-containing layer

[0027] Acipimox 250mg

[0028] Polyoxyethylene 200mg

[0029] Mannitol 20mg

[0030] Magnesium Stearate 3mg

[0031] Anhydrous ethanol amount

[0032] booster layer

[0033] Sodium Alginate 90mg

[0034] Sucrose 15mg

[0035] Semi-permeable coating film prescription:

[0036] Cellulose acetate 18g

[0037] Macrogol 4000 4g

[0038] Solvent prescription for dissolving film coating material:

[0039] Acetone 1000mL

[0040] Distilled water 20mL

[0041] Preparation Process:

[0042] Pass the prescribed amount of medicine, polyoxyethylene with a molecular weight of 200,000, and mannitol through an 80-mesh sieve, mix evenly, use absolute ethanol as a binder to make a soft material, and granulate with a 20-mesh sieve. After the wet granules are dried, sieve through a 18-mesh sieve Granules, dry granules and lubricants are...

Embodiment 2

[0044] Tablet prescription:

[0045] Drug-containing layer

[0046] Acipimox 250mg

[0047] Gum Arabic 300mg

[0048] Sodium chloride 30mg

[0049] Magnesium Stearate 5mg

[0050] 95% ethanol appropriate amount

[0051] booster layer

[0052] Polyoxyethylene PEO WSR301 100mg

[0053] Lactose 10mg

[0054] Semi-permeable coating film prescription:

[0055] Ethyl cellulose 20g

[0056] Macrogol 6000 4g

[0057] Solvent prescription for dissolving film coating material:

[0058] Acetone 500mL

[0059]Distilled water 30mL

[0060] Preparation Process:

[0061] Pass the prescribed amount of medicine, gum arabic, and sodium chloride through an 80-mesh sieve, mix evenly, use 95% ethanol as a binder to make a soft material, granulate with a 20-mesh sieve, and after the wet granules are dried, granulate with an 18-mesh sieve and dry The drug layer is obtained after the granules and lubricant a...

Embodiment 3

[0063] Tablet prescription:

[0064] Drug-containing layer

[0065] Acipimox 250mg

[0066] Polyoxyethylene 150mg

[0067] Lactose 10mg

[0068] Micronized silica gel 3mg

[0069] Anhydrous ethanol amount

[0070] booster layer

[0071] Polyoxyethylene 130mg

[0072] Sodium chloride 17mg

[0073] Semi-permeable coating film prescription:

[0074] Cellulose acetate 12g

[0075] Acrylic 8

[0076] Macrogol 1500 5g

[0077] Solvent prescription for dissolving film coating material:

[0078] Acetone 1000mL

[0079] Distilled water 30mL

[0080] Preparation Process:

[0081] Pass the prescribed amount of medicine, polyoxyethylene with a molecular weight of 500,000, and lactose through a 80-mesh sieve, mix evenly, use absolute ethanol as a binder to make a soft material, granulate with a 20-mesh sieve, and dry the wet granules, then sieve through a 18-mesh sieve Granules, d...

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Abstract

The invention belongs to the technical field of medicinal preparations, which discloses an acipimox push-pull osmotic pump controlled-release tablet and a preparation method thereof. The acipimox push-pull osmotic pump controlled-release tablet comprises a label and a controlled-release coating membrane which is coated outside the label and has medicine-release holes, wherein a medicine layer comprises the following components: 250mg of acipimox, 100-300mg of supensoid agent, 10-80mg of permeation pressure active substance, 2-7mg of lubricant and proper bonding agents; a boosting layer comprises the following components: 50-150mg of swelling agent and 5-50mg of permeation pressure active substance; a semipermeable coating membrane comprises the following components: 10-20g of semipermeable high polymer material, 2-6g of water-solubility pore-foaming agent and proper organic solvents; the weight of the coating membrane is 6-12 percent of the weight of the label, and 1-2 medicine-release holes are prepared on a medicine-content layer of a coating tablet by a laser or power drill. By regulating the label and a coating membrane prescription, the acipimox push-pull osmotic pump controlled release tablet can effectively regulate the constant release rate of medicines, thereby obtaining balanced blood concentration, reducing medicine-taking times, increasing the compliance of patients and achieving good lipid-regulating effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a bilayer osmotic pump controlled-release tablet of acipimus and a preparation method thereof. Background technique [0002] Acipimox is a derivative of niacin, its mechanism of action is to inhibit the decomposition of free fatty acids (FFA) from adipose tissue, reduce the release of FFA from adipose tissue, thereby reducing the synthesis of triglycerides, and by inhibiting the The synthesis of high-density lipoprotein (VLDL) and low-density lipoprotein (LDL) reduces the concentration of triglyceride (TG) and total cholesterol (TC) in the blood. [0003] As a new broad-spectrum and long-acting lipid-regulating drug, acilimus has good lipid-lowering effect, few adverse reactions, good tolerance, and can effectively reduce the risk of coronary heart disease. It is the most promising lipid-lowering drug in the niacin preparations so far. Compared with niacin, it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K31/4965A61P3/06
Inventor 潘卫三杨星钢刘岩关津刘强庞茗之
Owner SHENYANG PHARMA UNIVERSITY
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