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Method for detecting Resina Draconis drug

A technology of dragon's blood and its determination method, which is applied in the field of quality control of dragon's blood medicinal materials

Active Publication Date: 2013-03-20
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] "National Standards of the State Drug Administration" [WS 3 -082(Z-016)-99(Z)] included detection methods for the properties, TLC identification, and content determination of dracaine B of Dracaena dracaena, and the national standard did not include p-total phenols. and 7,4'-dihydroxyflavone content determination items; in addition, after searching, No. 200510010851.1 patent provides a kind of quality control method for detecting the content of dragon blood A and dragon blood in the medicinal material of dragon's blood, but the method There is also no detection of the content of total phenols and 7,4'-dihydroxyflavones in the medicinal materials of dragon's blood. The assay method of content, but also provides another method for assaying dragon's blood B which is different from the previous method, not only that, the present invention also provides the standard fingerprint spectrum of dragon's blood medicinal material and the application method of the spectrum

Method used

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  • Method for detecting Resina Draconis drug
  • Method for detecting Resina Draconis drug
  • Method for detecting Resina Draconis drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0246] Embodiment 1: the content assay method of total phenol

[0247] a. Source of reference substance: 7,4′-dihydroxyflavone, used for content determination, with a purity of 98.23%

[0248] Preparation of the reference substance solution: Take an appropriate amount of 7,4′-dihydroxyflavone, weigh it accurately, put it in a brown measuring bottle, add absolute ethanol to make a solution containing 28 μg per 1 ml, and obtain it;

[0249] b. Preparation of standard curve: Accurately measure reference substance solution 0, 1.0, 1.5, 2.0, 2.5, 3.0ml, put them in 25ml measuring bottles respectively, add absolute ethanol to 5ml, add 0.2% dodecylsulfonic acid Sodium solution 2ml, 0.5% potassium ferricyanide solution 1ml, 0.8% ferric chloride solution 1ml, shake well, place in a dark place for 4min, add 0.1M hydrochloric acid to the mark, shake well, put in dark place According to the ultraviolet-visible spectrophotometry method of appendix VB of the Chinese Pharmacopoeia 2005 edit...

Embodiment 2

[0254] Embodiment 2: the content assay method of total phenol

[0255] a. Source of reference substance: 7,4′-dihydroxyflavone, used for content determination, with a purity of 98.23%

[0256] Preparation of the reference solution: take an appropriate amount of 7,4′-dihydroxyflavone, accurately weigh it, put it in a brown measuring bottle, add absolute ethanol to make a solution containing 32 μg per 1 ml, and obtain it;

[0257] b. Preparation of standard curve: Accurately measure reference substance solution 0, 1.0, 1.5, 2.0, 2.5, 3.0ml, put them in 25ml measuring bottles respectively, add absolute ethanol to 5ml, add 0.3% dodecylsulfonic acid Sodium solution 2ml, 0.6% potassium ferricyanide solution 1ml, 0.9% ferric chloride solution 1ml, shake well, put it in a dark place for 5min, add 0.1M hydrochloric acid to the mark, shake well, put it away from light According to the ultraviolet-visible spectrophotometry method of appendix VB of the Chinese Pharmacopoeia 2005 edition,...

Embodiment 3

[0262] Embodiment 3: the assay method of total phenol

[0263] a. Source of reference substance: 7,4′-dihydroxyflavone, used for content determination, with a purity of 98.23%

[0264] Preparation of the reference substance solution: Take an appropriate amount of 7,4′-dihydroxyflavone, weigh it accurately, put it in a brown measuring bottle, add absolute ethanol to make a solution containing 35 μg per 1 ml, and obtain it;

[0265] b. Preparation of standard curve: Accurately measure reference substance solution 0, 1.0, 1.5, 2.0, 2.5, 3.0ml, put them in 25ml measuring bottles respectively, add absolute ethanol to 5ml, add 0.4% dodecyl sulfonic acid 2ml of sodium solution, 1ml of 0.7% potassium ferricyanide solution, 1ml of 1.0% ferric chloride solution, shake well, place in a dark place for 10min, add 0.1M hydrochloric acid to the mark, shake well, put in dark place According to the ultraviolet-visible spectrophotometry method of appendix VB of the Chinese Pharmacopoeia 2005 e...

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Abstract

The invention provides a method for controlling the quality of Resina Draconis drug. The method can be one or more of the following four methods for controlling the quality: (1) determining the content of total phenols; (2) determining the content of 7,4'-dihydroxyflavone; (3) determining the content of loureirin B; and (4) detecting high performance liquid chromatography fingerprint. The invention provides an accurate and precise method for controlling the quality with good stability, which can effectively control the quality of the Resina Draconis drug.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and relates to a quality control method for Chinese medicinal materials, in particular to a quality control method for dragon's blood medicinal materials. technical background [0002] Dracaena is the resin obtained by extracting the fat-containing wood of Dranaena cochinchinensis (Lour.) S.C.Chen. Mainly produced in Guangxi and Yunnan. According to "Compendium of Materia Medica", it is warm in nature, flat, sweet, salty, non-toxic, enters the blood system, and returns to the three meridians of lung, spleen, and kidney. Muscle sores and other significant effects. Modern medical research has confirmed that dragon's blood can improve the body's microcirculation, adjust the body's metabolism, and improve the body's immune function. [0003] "National Standards of the State Drug Administration" [WS 3 -082(Z-016)-99(Z)] included detection methods for the properties, TLC identif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889G01N21/33G01N30/36G01N30/86
Inventor 萧伟屠鹏飞王振中刘涛徐玉玲毕宇安邹艳萍章晨峰吴云孙永城
Owner JIANGSU KANION PHARMA CO LTD
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