Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Uniconazole slow-release microcapsules and preparation method thereof

A technology of uniconazole and microcapsules, applied in the field of agriculture, can solve the problems of easy drift, low bioavailability, easy optical isomerization inactivation, etc.

Active Publication Date: 2013-09-11
CHINA AGRI UNIV
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the commercial preparations of uniconazole are mainly emulsifiable concentrates and wettable powders, which have application problems such as easy drift, easy optical isomerization inactivation, and low bioavailability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Uniconazole slow-release microcapsules and preparation method thereof
  • Uniconazole slow-release microcapsules and preparation method thereof
  • Uniconazole slow-release microcapsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1, Preparation of Uniconazole Sustained-release Microcapsules with Average Particle Size of 75 μm

[0030] The original drug selects the original drug of 97% uniconazole produced by Jiangsu Qizhou Green Chemical Co., Ltd. (the following examples are the same).

[0031] Weigh 0.5g of sodium alginate and dissolve it in 20mL of water, slowly add 1.0mL of sorbitan monooleate polyoxyethylene ether under stirring at 800rpm, continue stirring and emulsifying at the same rate for 10min; weigh 0.1g of uniconazole solution In 2.0mL acetone, slowly add 0.5mL tristyrylphenol polyoxyethylene polyoxypropylene ether under stirring at 1500rpm, stir and emulsify for 5min; slowly add uniconazole emulsion into the emulsified In the sodium alginate solution, continue to stir and emulsify for 30 minutes until the mixed solution is evenly dispersed; set the inlet temperature of the spray dryer to 150°C, and the outlet temperature to 95°C, and use the spray dryer to solidify and dry t...

Embodiment 2

[0037] Example 2, Preparation of Uniconazole Sustained-release Microcapsules with Average Particle Size of 20 μm

[0038]Weigh 2.0 g of chitosan and 1.0 g of gelatin and dissolve them in 100 mL of 2% acetic acid solution, slowly add 2 mL of sorbitan monolaurate into the above solution under stirring at 800 rpm, and continue stirring for 20 min. Then 1.0 mL of fatty alcohol polyoxyethylene ether was mixed with 2.0 mL of 7.5% uniconazole ethanol solution, and stirred and emulsified at 1000 rpm for 10 min. Then slowly add the uniconazole emulsion into the acetic acid solution of emulsified chitosan and gelatin under stirring at 1200 rpm, and continue stirring for 45 minutes until the mixture is evenly dispersed. Finally, the obtained mixed solution is solidified and dried in a spray dryer with an inlet temperature of 135° C. and an outlet temperature of 85° C., and the obtained powder is uniconazole sustained-release microcapsules.

[0039] The method for measuring the performan...

Embodiment 3

[0041] Example 3, Preparation of Uniconazole Sustained-release Microcapsules with Average Particle Size of 5 μm

[0042] Weigh 0.3g of sodium alginate and 0.15g of gelatin and dissolve them in 20mL of water, slowly add 1.0mL of nonylphenol polyoxyethylene ether into the above solution under stirring at 1000rpm, and continue stirring for 20min. Then 1.0 mL of polyoxyethylene polyoxypropylene ether of sorbitan was mixed with 2.0 mL of 6% uniconazole isopropanol solution, and stirred and emulsified at 1200 rpm for 8 min. Then slowly add the uniconazole emulsion into the emulsified sodium alginate and gelatin solution under stirring at 1800rpm, and continue stirring for 40 minutes until the mixture is uniformly dispersed. Finally, the obtained mixed solution is solidified and dried in a spray dryer with an inlet temperature of 145° C. and an outlet temperature of 90° C., and the obtained powder is uniconazole sustained-release microcapsules.

[0043] The method for measuring the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses uniconazole microcapsules and a preparation method thereof. The uniconazole microcapsules consist of the following substances in parts by mass: 0.1 to 0.5 part of uniconazole, 0.5 to 4.0 parts of degradable polymer and 0.55 to 10 parts of hydrophilic emulsifier, wherein capsule cores of the uniconazole microcapsules are uniconazole. The preparation method prepares the uniconazole slow-release microcapsules by selecting degradable polymer capsule materials and combinations thereof different in proportion, utilizing the hydrophilic emulsifier to emulsify the capsule materials and the capsule cores respectively and then spray-drying obtained emulsified mixed solution of the capsule materials and the capsule cores at a certain inlet / outlet temperature. The slow-release microcapsules are safe for human bodies and little in environmental pollution, and have the advantages of controlling or delaying the release of uniconazole, improving bioavailability, prolonging persistent-effect period, reducing application dosage, reducing the degradation of active components in environment, improving the stability of the active components, and the like.

Description

technical field [0001] The invention belongs to the technical field of agriculture, and relates to a slow-release microcapsule of a plant growth regulator and a preparation method thereof, in particular to uniconazole slow-release microcapsules and a preparation method thereof. Background technique [0002] Uniconazole is a new type of triazole plant growth regulator. It has been widely used in production. Its activity is 6-10 times higher than that of paclobutrazol, but its residual amount in soil is only 1 / 3 of that of paclobutrazol. 10. It has little impact on subsequent crops, no secondary control phenomenon, and has a good market prospect. English common name of the compound: uniconazole; CAS registration number: 83657-22-1; chemical name: (E-1-(p-chlorophenyl)-2-(1,2,4-triazol-1-yl)- 4,4-Dimethyl-1-penten-3-ol; formula C 15 h 18 ClN 3 O; the structural formula is shown in formula I; physical and chemical properties: the pure product of uniconazole is a white crysta...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/28A01N43/653A01P21/00
Inventor 段留生朱晓峰谭伟明周繁李召虎田晓莉张明才
Owner CHINA AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com