Preparation process of 68Ge line source used for PET attenuation correction

A preparation process and attenuation correction technology, applied in the field of nuclear medicine imaging, can solve the problems of affecting imaging correction quality, poor radiation resistance, dose distribution changes, etc., and achieve good linear uniformity, convenient procurement, and easy filling. Effect

Active Publication Date: 2012-07-25
HTA CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0006] Ion exchange adsorption preparation 68 Ge line source, the ion exchange resin used as the adsorption medium is mostly poor in radiation resistance, long-term irradiation will cause the resin to age or break, resulting in changes in dose distribution and affecting the quality of image correction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Concrete preparation process is as follows:

[0018] This embodiment mainly adopts two steps to complete the preparation.

[0019] first step 68 Adsorption of Ge. The concentration of nitric acid solution, the concentration of Ge ions and the selection of oscillation adsorption time in the process play a key role in improving the utilization rate of Ge ions, the adsorption rate and the uniformity of adsorption. In this embodiment, 10 ml of nitric acid solution with a concentration of 15 mol / L and 1 ml of germanium chloride solution with a concentration of 25 mg / ml are mixed, and then 0.1 ml of carrier-free chlorine [ 68 Ge] germanium solution, configured as a mixed system. The concentration of nitric acid solution in the mixed system is 13.6mol / L, and the concentration of Ge ions is 2.3mg / ml. Put 3g of ceramic microspheres with a particle size of 100-200 mesh into the mixing system, and react for 15 minutes under shaking conditions to fully absorb the ceramic micros...

Embodiment 2

[0024] The present embodiment is the same as Example 1, and its difference is that in the first step, the nitric acid solution adopts 10ml concentration to be 15mol / L and 2.5ml concentration to mix the germanium chloride solution that is 25mg / ml, and the nitric acid in the mixed solution that is configured The concentration is 12 mol / L, and the concentration of Ge ions is 5 mg / ml. Add ceramic microspheres with a particle size of 100 to 200 mesh into the mixing system, shake and react for 20 minutes, and wash the ceramic microspheres with 12mol / L nitric acid, 1mol / L nitric acid, water, and acetone in sequence. According to the formula, The adsorption efficiency of this example is

Embodiment 3

[0026] The present embodiment is the same as Example 1, and its difference is that in the first step, the nitric acid solution is mixed with 10ml concentration of 15mol / L and 0.2ml concentration of germanium chloride solution of 25mg / ml, and the concentration of nitric acid in the mixed solution is configured The concentration is 15 mol / L, and the concentration of Ge ions is 0.5 mg / ml. Add ceramic microspheres with a particle size of 100-200 mesh into the mixing system, shake and react for 10 minutes, and wash the ceramic microspheres with 15mol / L nitric acid, 1mol / L nitric acid, water, and acetone in sequence. According to the formula, The adsorption efficiency of this embodiment is 90%.

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Abstract

The invention discloses a preparation process of a 68Ge line source used for PET attenuation correction, which aims to provide a preparation process of a 68Ge line source which has high utilization rate, uniform activity distribution and low cost and is used for PET attenuation correction. The process comprises the following steps: (1) putting a ceramic microsphere into a mixed solution of nitricacid and germanium chloride [68Ge], carrying out an oscillating reaction, taking out after the 68Ge is absorbed on the ceramic microsphere, washing and then airing; and (2) evenly filling the dried ceramic microsphere adsorbed with the 68Ge into a stainless steel tube one end of which is sealed, sealing the other end of the stainless steel tube by using glass wool, then sleeving the stainless steel tube into a stainless steel sleeve and finally, connecting the stainless steel sleeve with a magnetic tungsten steel base, wherein the concentration of the nitric acid in the mixed solution in the step (1) is 12 to 15mol / L, the concentration of Ge ions is not greater than 5mg / ml, and the adsorption time is 10 to 20min.

Description

technical field [0001] The invention relates to the field of nuclear medicine imaging, in particular to a PET attenuation correction 68 The preparation process of Ge line source. Background technique [0002] 68 As a radiation source for PET attenuation correction, Ge line source is widely used in attenuation correction of special PET and some PET / CT imaging, such as SIEMENS ECAT PET, GE Advance PET, GE Discovery LS PET / CT, etc. , especially special-purpose PET, 68 Ge line source correction is a classic attenuation correction method in special PET imaging. 68 The Ge line source is usually made of surface adsorbed radioactive 68 Ge carrier microspheres (ceramics, SiO 2 、TiO 2 , SnO 2 etc.) welded and sealed in stainless steel tubes. [0003] Currently, will 68 There are many methods for uniformly adsorbing Ge on the carrier, and the common ones are electroplating, colloidal method and adsorption method. [0004] The electroplating method is difficult to popularize a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G21G4/08
Inventor 尹卫李忠勇陈大明白红升高惠波韩连革崔洪起张文辉金小海
Owner HTA CO LTD
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