Brominated butyl rubber plug for sterile powder for injection

Abstract

The invention relates to a brominated butyl rubber plug for sterile powder for injection, which belongs to the technical field of medical bottle plugs and is characterized in that the brominated butyl rubber plug for sterile powder for injection comprises following ingredients in parts by weight: 49 to 50 parts of brominated butyl rubber, 42 to 43 parts of calcined china clay, 0.4 to 0.5 parts ofstearic acid, 2 to 3 parts of Tissuemat E, 2 to 3 parts of zinc oxide, 0.7 to 0.8 parts of phenolic resin, 1 to 2 parts of titanium dioxide, 0.1 to 0.2 parts of soot carbon and 0.2 to 0.3 parts of magnesium oxide. The brominated butyl rubber plug of the invention can be vulcanized by using few cleaning vulcanized agents, has low quantity of auxiliary agents and impurities, and has the advantages of high air / vapor penetration resistance, chemical agent and solvent resistance, ozone resistance, weathering resistance, thermal stability, low compression deformation and good bioinert. The brominated butyl rubber plug of the invention can be widely used for subpackage of antibiotic powder-injection medicine.

Description

technical field [0001] The invention belongs to the technical field of medicinal bottle stoppers, in particular to a bromobutyl rubber stopper for sterile powder for injection. Background technique [0002] Drugs are a special commodity, and their efficacy and quality are directly related to personal health and safety. The materials and structural forms of drug packaging, especially the packaging materials that directly contact drugs, play a decisive role in ensuring the stability of drugs. Unsuitable packaging materials can cause exudation, adsorption, and even chemical reactions of active pharmaceutical ingredients, leading to drug failure and sometimes serious toxic side effects. Therefore, whether the selection of pharmaceutical packaging materials is appropriate is an important indicator for evaluating the quality of pharmaceuticals. [0003] Rubber stoppers are an important part of bottle sealing materials in pharmaceutical packaging, mainly including natural rubber a...

AI Technical Summary

Problems solved by technology

Third, poor air tightness

The macromolecules of natural rubber stoppers have high flexibility and high diffusivity for various gases, thus affecting their sealing performance

Fourth, the use of complex technology

However, in the actual production process, polyisoprene rubber plugs will also cause some problems, such as: chemical index fluctuations, easy mold sticking during vulcanization, sticky products, strict cleaning requirements, etc.