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Hemostat and preparation method thereof

A technology of hemostatic agent and liquid preparation, which is applied in the field of preparation of the hemostatic agent, can solve the problems of poor hydrophilicity and unsatisfactory hemostatic effect, and achieve the effect of preventing rebleeding, less stringent preparation conditions, and no toxic and side effects

Inactive Publication Date: 2012-04-04
苏州汇涵医用科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the hemostatic dressings used in surgical operations in hospitals use gelatin sponge. Due to the poor hydrophilicity of this material, the hemostatic effect is not ideal.
Although the performance of raw gelatin sponge is better than that of gelatin sponge, it is difficult to apply in large scale clinically because of the unsatisfactory hemostatic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A) Preparation of termite fungus garden composition powder, termite fungus garden composition powder can be obtained directly from commercially available channels, and can also be self-made. The test (inspection) of the termite main colony bacteria garden containing the termite population excavated from the termite tunnel, confirming that the termite population is the black-winged soil termite population, and confirming that the termite main colony mushroom garden contains the cockroach fungus (Termitomyces albuminosas). heim), Odontotermes formosanus ) the main nest fungus garden, the aforementioned tests can be performed independently, or by a termite control research institution, or by the Chinese Beijing Institute of Nutrient Sources or similar departments (institutions) mentioned in the background art by the applicant. After the test is completed and the qualification is confirmed, first place the black-winged soil termite population and the black-winged soil ter...

Embodiment 2

[0034] Only the weight ratio of the black-winged soil termite population in the step A) and the black-winged soil termite main nest fungus garden containing gallindromycosis is changed to 1: 20, the temperature of the constant temperature drying box is adjusted to 90 ° C, and the drying time is changed to 280min, the sieving mesh number after ball milling is 100 mesh sieve, the time of radiation sterilization is changed to 235min, and the solvent is changed to water (ie, water extraction);

[0035] Only the amount of the termite fungus garden composition powder in step B) was changed to 11g, and the stirring time that it was added into the distilled water with a purity of 0.12 μs / cm in 20g (20ml) was changed to 9min;

[0036] Only the amount of collagen in step C) was changed to 4g, the deionized water was changed to distilled water with a purity of 0.12 μs / cm, the stirring time was changed to 6min, and the mass percentage concentration of bactericide, that is, hydrogen p...

Embodiment 3

[0040] Change the weight ratio of the black-winged soil termite population in the step A) and the termite main nest fungus garden of the black-winged soil containing gallicaria to 1: 18, change the temperature of the constant temperature drying box to 85 ° C, and change the drying time to 290min, the sieving mesh number after ball milling was changed to 85 meshes, and the radiation sterilization time was changed to 200min;

[0041] Change the amount of the termite fungus garden composition powder in step B) to 12g, change the stirring time to 8min, and change the purity of deionized water to 0.1μs / cm;

[0042] The amount of collagen in step C) is changed to 5g, the stirring time is changed to 7min, the consumption of bactericide, that is, hydrogen peroxide, is changed to 7.4g, and then the time of stirring is changed to 33min;

[0043] In step D), the time of stirring and then stirring was changed to 7min, and the amount of deionized water with a purity of 0.1 μs / cm wa...

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Abstract

The invention discloses a hemostat and a preparation method thereof. A finished product liquor per 1000 g comprises 10-16 g of termite fungus garden composition powder, 4-6 g of collagen, 0.02-0.04 g of ternary acid, 7-9 g of bactericidal agent and the balance of water. The invention has the advantages that the termite fungus garden composition powder containing rich nutrient contents is utilizedin the prescription, the functions of detumescence, convergence and hemostasis are achieved, meanwhile the weak body is tonified without any side effect; the collagen has very strong affinity with different cells, and also has ideal affinity with growth factors which play a key role in the process of wound healing, after blood coagulation, the collagen can also prevent bleeding again through stimulating the regeneration and the repair of tissues. The hemostat is not fastidious about the using object, has fast hemostasis effect, excellent functions of anti-inflammatory, detumescence and acesodyne without toxic or side effect, or untoward reaction of stimulations. The preparation method has less technical steps and non-rigorous preparation condition, and can be suitable for the industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of surgical medication, in particular to a hemostatic agent, which is suitable for traumatic hemostasis and surgical hemostasis on the human body, and also relates to a preparation method of the hemostatic agent. Background technique [0002] In daily life, when people encounter skin being rubbed by foreign objects, they are used to smearing with saliva, because saliva has hemostatic function, and the mystery of saliva's hemostatic function has been awarded the Nobel Prize in Medicine (1986) The American scientist Stan Kerns revealed that the scientist found that there is a kind of living cell in saliva, which contains fifty-three amino acid polypeptide substances (referred to as cell chemokine). <ecf>). The biggest feature of polypeptide substances is that they can promote the proliferation and differentiation of cells, and replace senescent and dead cells with new cells. [0003] It is because of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K35/64A61P7/04A61K33/40
Inventor 冯永良孟孝平孟勇朱世辉张琦
Owner 苏州汇涵医用科技发展有限公司
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