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Costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof

A technology of corynelide and gastrointestinal diseases, applied in the field of medicine, can solve problems such as endocrine system harm, harm to fetal and infant health, mercury harm, etc.

Active Publication Date: 2011-09-07
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its formula contains cinnabar, its function is to calm the nerves, but cinnabar contains mercury, which is very harmful to the human body. It is a subtle and continuous absorption process. Long-term exposure to mercury will cause chronic poisoning: Harmful to human nerves, digestion, endocrine system and kidneys; people with neurasthenia may cause symptoms such as headache, dizziness, insomnia, memory loss, and general fatigue; and long-term exposure to mercury by pregnant and breastfeeding women may also harm the fetus and baby's health
In addition, mercury-containing medicines are subject to certain restrictions when exported to other countries. For example, Singapore requires that the mercury content must be less than 0.5ppm, while the requirements for some European countries are more stringent.

Method used

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  • Costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof
  • Costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof
  • Costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] a. Take the following weight proportion raw materials: 3 g of coynelide, 3 g of naringin, 1 g of total santalol, 1 g of chrysophanol, 0.1 g of artificial musk, 3 g of ligustrazine, 1 g of croton oil and 3 g of jujube polysaccharide; 6 -Hydroxy-2-[2-(4'-methoxyphenethyl)]chromone (A) 3g, 6-hydroxy-2-(2-phenylethyl)chromone (B) 3g, albinoic acid 0.3g, shiragiol 0.3g, emodin 1g, rhein 1g, magnolol 3g, honokiol 3g for later use;

[0119] b. Mix the above raw materials with an appropriate amount of starch evenly, add an appropriate amount of magnesium stearate, mix evenly, and press to obtain.

Embodiment 2

[0121] a. Get the following weight proportion raw materials: 15g of coynelide, 15g of naringin, 10g of total santalol, 10g of chrysophanol, 0.6g of artificial musk, 15g of ligustrazine, 10g of croton oil and 50g of jujube polysaccharide;

[0122] 6-Hydroxy-2-[2-(4'-methoxyphenethyl)] chromone (A) 15g, arboric acid 5g, arborinol 5g, magnolol 20g, honokiol and its 20g standby;

[0123] b. Add sodium carboxymethyl cellulose and powdered sugar to the above raw materials, mix well, make granules, sieve, and dry to obtain.

Embodiment 3

[0125] a. Take the following weight proportion raw materials: 3 g of coynelide, 15 g of naringin, 1 g of total santalol, 1 g of chrysophanol, 0.6 g of artificial musk, 3 g of ligustrazine, 1 g of croton oil and 50 g of jujube polysaccharide;

[0126]The other raw materials are: 6-hydroxyl-2-[2-(4'-methoxyphenethyl)]chromone (A) 3g, 6-hydroxyl-2-(2-phenethyl)chromone (B) 3g, emodin 1g, rhein 1g, magnolol 20g, honokiol 3g for subsequent use;

[0127] b. The above raw materials and an appropriate amount of polyethylene glycol 6000 are heated to melt, and the dropping speed is 85-90 drops / min, and they are dropped into the cooled liquid paraffin to make drop pills.

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PUM

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Abstract

The invention relates to a costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from basic medicines and other medicines, wherein, the basic medicines comprise the following components: costunolide, naringin, santalol, chrysophanol, artificial musk, ligustrazine, croton oil and polysaccharides from Chinese red dates. The traditional Chinese medicine composition is mainly used for clinically treating diseases such as acute diarrhea, irritable bowel syndrome and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof. Background technique [0002] Diarrhea can be divided into infectious and non-infectious categories. Infectious diarrhea is divided into bacterial infection and viral infection; non-infectious diarrhea can be caused by various reasons such as improper diet, food allergies, changes in life patterns, sudden changes in climate, and even emotional stress. Traditional Chinese medicine believes that diarrhea refers to increased frequency of defecation, clear and thin stool, or even watery. The main lesion of diarrhea lies in the spleen, stomach and large and small intestine. The causes of the disease include exogenous evils, injury from diet, disharmony of the seven emotions, internal resistance of dampness, and weakness of viscera. The pathogenicity of dampness seen clinically...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61P1/08A61P1/12A61P1/14A61K31/045A61K31/05A61K31/19A61K31/192A61K31/122A61K31/352A61K31/365A61K31/496A61K31/7048A61K31/715
CPCY02A50/30
Inventor 陈坚王磊袁学海王伟杨瑾王春晨郝忻
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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