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Medicine composition of naloxone hydrochloride and polyethylene glycol and preparation method thereof

A technology of naloxone hydrochloride and polyethylene glycol, which is applied in the field of medicine, can solve problems such as unstable light exposure and difficulty in mastering clinical dosage, and achieves difficult degradation, safe and effective clinical medication, convenient dosage and effective dosage. The effect of dosing on mastery

Active Publication Date: 2010-06-16
BEIJING SIHUAN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems that the existing naloxone hydrochloride preparations are unstable to light and the clinical dosage is difficult to grasp, the present invention provides a medicine of naloxone hydrochloride and polyethylene glycol with stable properties, safety, controllability and convenient storage. Composition, the pharmaceutical composition can be made into any pharmaceutically acceptable dosage form, especially injection

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  • Medicine composition of naloxone hydrochloride and polyethylene glycol and preparation method thereof
  • Medicine composition of naloxone hydrochloride and polyethylene glycol and preparation method thereof
  • Medicine composition of naloxone hydrochloride and polyethylene glycol and preparation method thereof

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Embodiment Construction

[0049] Hereinafter, the above-mentioned content of the present invention will be further described in detail through specific implementations in the form of examples. However, it should not be understood that the scope of the above-mentioned subject of the present invention is limited to the following embodiments. All technologies implemented based on the foregoing content of the present invention belong to the scope of the present invention.

[0050] Example Preparation of the composition injection of the present invention

[0051] Prescription 1

[0052] Naloxone Hydrochloride 2g

[0053] Polyethylene glycol 2g

[0054] Add water for injection to 2000ml

[0055]

[0056] 1000 pieces in total

[0057] Prescription 2

[0058] Naloxone Hydrochloride 2g

[0059] Polyethylene glycol 1g

[0060] Add water for injection to 2000ml

[0061]

[0062] 1000 pieces in total

[0063] Preparation method of prescription 1, 2:

[00...

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Abstract

The invention belongs to the technical field of medicine, which discloses a medicine composition of naloxone hydrochloride and polyethylene glycol and a preparation method thereof. The weight percent of the naloxone hydrochloride to the polyethylene glycol of the composition is 1:0.1-10. The invention solves the problem that naloxone hydrochloride injection in the prior art is unstable to light, is convenient to master the application quantity and the effective dose and enables the clinical application to be safer and more effective.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition of naloxone hydrochloride and polyethylene glycol and a preparation method thereof. 2. Background technology [0002] Naloxone Hydrochloride is a specific morphine receptor antagonist, its chemical name is 17-allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride, Synthesized in 1960, began to be used in clinical practice in the United States in 1971, and was included in the United States Pharmacopoeia in 1975. The drug has greater affinity for opioid receptors than morphine and enkephalin. It can competitively block and replace the binding of opioids and receptors, clear the symptoms of opioid poisoning, and quickly induce withdrawal in opioid addicts symptom. It was first synthesized by the Institute of Toxicology and Drugs of the Academy of Military Medical Sciences in 1985, and obtained the naloxone new drug certificate and produ...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K47/34A61K9/08A61P39/02A61P25/30A61P9/10A61P43/00A61K47/10
Inventor 车冯升郭维城贾中新霍彩霞孟宪慧
Owner BEIJING SIHUAN PHARMA
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