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Ferroferric oxide/calcium phosphate nuclear shell structure nano particle and preparation method thereof

A technology of ferroferric oxide and nanoparticles, applied in medical science, prosthesis, etc., can solve the problems that have not been reported, and achieve the effect of accelerating the biomineralization process, promoting repair and regeneration, and simple preparation and processing methods

Active Publication Date: 2010-06-09
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Using the sol-gel method to coat calcium phosphate on ferroferric oxide to form a core-shell structure, combining the superparamagnetism of nanometer ferric oxide with the good biocompatibility and bioactivity of calcium phosphate has not yet been seen. someone reported

Method used

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  • Ferroferric oxide/calcium phosphate nuclear shell structure nano particle and preparation method thereof
  • Ferroferric oxide/calcium phosphate nuclear shell structure nano particle and preparation method thereof
  • Ferroferric oxide/calcium phosphate nuclear shell structure nano particle and preparation method thereof

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Effect test

Embodiment 1

[0025] (1) Mix 9.197g ferric chloride hexahydrate with 4.335g ferrous chloride tetrahydrate (molar ratio 2:1) and 80ml deionized water, stir mechanically in a water bath at 40°C, and add 80ml 3mol / L of Sodium hydroxide solution, after the completion of the reaction, use the magnetite to collect the ferric oxide, rinse with deionized water and ethanol for 3 times each. Dry at 60° C. for 12 hours to obtain ferric oxide nanoparticles. Mix 0.2g iron ferric oxide nanoparticles, 1g sodium citrate and 20ml deionized water, mechanically stir in a water bath at 40°C for 12 hours, centrifuge at 10000r / min to remove the supernatant, add deionized water to separate and remove the supernatant again , poured into 30ml of deionized water and centrifuged to obtain the supernatant, which was stable ferroferrogen tetroxide magnetic fluid with a mass concentration of 1.05%.

[0026] (2) Mix 3.643g triethyl phosphate, 2.76g ethanol and 1.08g deionized water to form a solution, and add nitric aci...

Embodiment 2

[0031](1) Mix 9.197g of ferric chloride hexahydrate with 4.621g of ferrous chloride tetrahydrate and 80ml of deionized water, mechanically stir in a water bath at 40°C, add 70ml of 3mol / L sodium hydroxide solution dropwise, and react After completion, collect the prepared ferric oxide with a magnet, rinse with deionized water and ethanol three times each. Dry at 60° C. for 12 hours to obtain ferric oxide nanoparticles. Mix 0.8g of ferric oxide, 1g of sodium citrate and 20ml of deionized water, mechanically stir in a water bath at 40°C for 12 hours, centrifuge at a speed of 10,000r / min to remove the supernatant, add deionized water to separate and remove the supernatant again, pour Add 30 ml of deionized water and centrifuge to obtain the supernatant, which is a stable ferroferrogen tetroxide magnetic fluid with a mass concentration of 1.05%.

[0032] (2) Mix 3.643g of triethylphosphoric acid, 2.76g of ethanol and 1.08g of deionized water to form a solution, and dropwise add n...

Embodiment 3

[0036] (1) Mix 9.197g of ferric chloride hexahydrate with 5.124g of ferrous chloride tetrahydrate and 80ml of deionized water, mechanically stir in a water bath at 40°C, add 60ml of 3mol / L sodium hydroxide solution dropwise, and react After completion, collect the prepared ferric oxide with a magnet, rinse with deionized water and ethanol three times each. Dry at 60° C. for 12 hours to obtain ferric oxide nanoparticles. Mix 1.0g of ferric oxide, 1g of sodium citrate and 20ml of deionized water, mechanically stir in a water bath at 40°C for 12 hours, centrifuge at a speed of 10,000r / min to remove the supernatant, add deionized water to separate and remove the supernatant again, pour Add 30 ml of deionized water and centrifuge to obtain the supernatant, which is a stable ferroferrogen tetroxide magnetic fluid with a mass concentration of 1.05%.

[0037] (2) Mix 3.643g tributylphosphoric acid, 2.76g ethanol and 1.08g deionized water to make a solution, and add nitric acid dropwi...

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Abstract

The invention discloses a preparation method of a ferroferric oxide / calcium phosphate nuclear shell structure nano particle. The ferroferric oxide used as a nuclear structure is prepared by using a coprecipitation method, and magnetofluid with favorable dispersibility in water can be prepared by modifying the surface of the ferroferric oxide. A mixed solution with the molar ratio of calcium salt and phosphate of 1.0-1.6 is prepared, and the pH value of the solution is adjusted to be 1-10, and the solution is aged at low temperature to form precursor sol. The magnetofluid is uniformly dispersed into the sol to obtain the ferroferric oxide / calcium phosphate nuclear shell structure composite nano particle in the processes of drying and high-temperature sintering. The particle diameter of the composite nano particle is between 80nm and 120nm, wherein the particle diameter of the ferroferric oxide is between 8nm and 60nm. The composite particle is used for a cell regulation and bone repair project under the action of a magnetic field.

Description

technical field [0001] The present invention relates to a preparation method of biologically active nanoparticles with magnetic properties, in particular to a preparation method of iron ferric oxide / calcium phosphate core-shell structure nanoparticles; the present invention also relates to a biologically active nanoparticle with magnetic properties Particles, the composite particles can be used for cell regulation and bone repair engineering under the action of a magnetic field. Background technique [0002] With the rapid development of nanotechnology, nanomagnetic Fe 3 o 4 As a functional material, the research on its preparation process and product properties has received great attention. Nanomagnetic Fe 3 o 4 In addition to the mesoscopic properties of nanomaterials in physics and chemistry, it also has its special magnetic properties - mesoscopic magnetism, mainly including: quantum size effect, superparamagnetism, small size effect of magnetically ordered particles...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/58
Inventor 杨小平方舟刘海洋连鹏飞蔡晴林元华
Owner BEIJING UNIV OF CHEM TECH
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