Detection method of residual polychlorinated biphenyl in cosmetics with gas chromatography-mass spectrum method

A gas chromatography and mass spectrometry determination technology, applied in the detection field of polychlorinated biphenyl residues, can solve the problems of no detection of polychlorinated biphenyls and low general content, and achieve the effect of low detection limit and high sensitivity

Inactive Publication Date: 2010-06-02
THE INSPECTION & QUARANTINE TECH CENT ZHEJIANG ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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Problems solved by technology

[0005] At present, countries in the world have no strict residue limits for PCBs in cosmetics. PCBs are mainly brought into cosmetics

Method used

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  • Detection method of residual polychlorinated biphenyl in cosmetics with gas chromatography-mass spectrum method
  • Detection method of residual polychlorinated biphenyl in cosmetics with gas chromatography-mass spectrum method
  • Detection method of residual polychlorinated biphenyl in cosmetics with gas chromatography-mass spectrum method

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Embodiment Construction

[0025] A detailed description will be given below of specific embodiments of the present invention. The gas chromatography-mass spectrometry method of the present invention detects polychlorinated biphenyl residues in cosmetics, and the method comprises the following steps:

[0026] 1. Pretreatment

[0027] Weigh 2.0g (accurate to 0.01g) of solid cosmetics and grind them into powder as much as possible (semi-solid samples such as milky ones should be freeze-dried first). Mix the crushed cosmetic with 6g of diatomaceous earth, load the sample in the order of spacer, diatomite, mixed diatomite, and diatomaceous earth for accelerated solvent extraction (ASE), using n-hexane as the extraction solvent.

[0028] The ASE-passed solution was transferred to a concentration bottle, concentrated to near dryness at 40°C, fixed to volume with 9 mL of cyclohexane / ethyl acetate (1:1, v / v), passed through a membrane, and passed through gel purification (GPC). The solvent cyclohexane / ethyl a...

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Abstract

The invention relates to a detection method of residual polychlorinated biphenyl, in particular to a detection method of residual polychlorinated biphenyl in cosmetics with gas chromatography-mass spectrum method; in the method, a sample is extracted in an accelerating way by solvent, normal hexane is used as extractant, and then gel extraction and Florisil cartridge purification are carried out, and then the gas chromatography-mass spectrum method, selected ion canning detection and an external standard method are used for quantifying. The detection method has the following characteristics that: 1. in the method, the gel extraction and Florisil cartridge purification are firstly combined to measure residual polychlorinated biphenyl in cosmetics. 2. the solvent is adopted to carry out extraction in an accelerating way, and the gel extraction and Florisil cartridge purification are adopted, the gas chromatography-mass spectrum method is used for quantifying and determining the nature, and seven kinds of polychlorinated biphenyl in the matrix of the cosmetics are measured, and the method has the advantages of low detection limit and high sensitivity; the measuring low limit of PCL-180 which has the lowest response is 0.01mug.ml-1, and the linear range is set from 0,01mug.ml-1-0.10mug.ml-1.

Description

technical field [0001] The invention relates to a detection method for polychlorinated biphenyl residues, in particular to a detection method for detecting polychlorinated biphenyl residues in cosmetics by using gas chromatography-mass spectrometry. Background technique [0002] Chlorinated biphenyls (English abbreviation PCBs) are a kind of artificially synthesized organic compounds. Due to their good insulation, heat resistance and chemical stability, they have been mass-produced in the United States, Britain, Japan and other developed countries since the 1930s. Widely used as insulation and heat dissipation medium for batteries, transformers, power capacitors, and additives for insulating oil, paint, ink and other products. Polychlorinated biphenyls are organic substances with low water solubility and high fat solubility. Animal experiments on PCBs have shown that PCBs have an inducing effect on skin, liver, gastrointestinal system lesions and even cancer, and can interfe...

Claims

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Application Information

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IPC IPC(8): G01N30/72
Inventor 蒋沁婷周佳青陈笑梅丁慧瑛谢文朱晓雨刘海山黄雷芳
Owner THE INSPECTION & QUARANTINE TECH CENT ZHEJIANG ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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