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Synthesis method of taurine

A synthetic method, the technology of taurine, applied in the direction of sulfonic acid preparation, organic chemistry, etc., can solve the problems of difficult control, cumbersome process, expensive raw material cost, etc., and achieve the effect of less reaction steps and concise process

Inactive Publication Date: 2010-06-02
JIANGSU YUANYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method is difficult to control in the actual production process. The reaction takes monoethanolamine as the starting material, and is completed through salt formation, esterification, reduction and refining, and monoethanolamine is obtained by high-pressure ammoniation of ethylene oxide. Complex and expensive raw materials

Method used

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  • Synthesis method of taurine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Put 200 kilograms of water in a 1000-liter stainless steel high-pressure reactor with stirring, heating and devices, and add 145 kilograms of ammonium sulfite (80.0%) (1×10 3 mol), 44 kg (1.0×10 3 mol), then seal and heat, stir until the temperature in the kettle is 150°C to 160°C, and maintain the pressure in the kettle at 0.5-1MPa, and continue to react in between for 5 hours to obtain ammonium taurine salt solution, and lower the temperature while stirring When the temperature is below 50°C, add 50% sulfuric acid to adjust the pH value of the material in the kettle to be ≤7, and centrifuge to obtain 130 kg of crude taurine;

[0013] Put 130 kilograms of the above-mentioned crude product taurine into a 500L reaction kettle, add 200L of water and 0.1 kilogram of activated carbon, dissolve the crude product taurine under heating and stirring, filter and remove the activated carbon to obtain a colorless transparent liquid, and cool down to 5 DEG C, centrifuge and wash t...

Embodiment 2

[0019] Put 200 grams of water in a 1000 milliliter four-necked flask with stirring, heating and devices, and add 290 grams (2mol) of ammonium sulfite (80.0%), and feed 44 grams of ethylene oxide (99.9%) under stirring (1mol), then water-sealed and heated, stirred until the temperature in the kettle was 100°C to 115°C, and the pressure in the flask was maintained at normal pressure for 5 hours to obtain ammonium taurine salt solution, and the temperature was lowered to below 50°C while stirring , adding 50% sulfuric acid to adjust the pH value of the material in the kettle to be less than or equal to 7, and centrifuged to obtain 121 grams of crude product taurine;

[0020] Put 121 grams of the above-mentioned crude product taurine into a 500 milliliter four-neck flask with stirring, heating and devices, add 200 grams of water and 0.1 gram of activated carbon, dissolve the crude product taurine under heating and stirring, and remove the activated carbon by filtration to obtain c...

Embodiment 3

[0022] Put 200 grams of water in a 1000 milliliter four-necked flask with stirring, heating and devices, and add 145 grams (1mol) of ammonium sulfite (80.0%), and feed 88 grams of ethylene oxide (99.9%) under stirring (2mol), then water-sealed and heated, stirred until the temperature in the bottle was 105°C to 100°C, and reacted under normal pressure for 5 hours to obtain a taurine ammonium salt solution, which was cooled to below 50°C while stirring, and 30% sulfuric acid was added to adjust The pH value of the material in the kettle was ≤7, and it was centrifuged to obtain 129 grams of crude taurine;

[0023] Put 129 grams of the above-mentioned crude product taurine into a 500 milliliter four-neck flask with stirring, heating and devices, add 200 grams of water and 0.1 gram of activated carbon, dissolve the crude product taurine under heating and stirring, and remove the activated carbon by filtration to obtain color transparent liquid, cooled to 5°C under stirring, centri...

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Abstract

The invention relates to a synthesis method of taurine, belonging to the technical field of organic chemical synthesis. The synthesis method comprises the following steps of: reacting the oxirane with ammonium sulfite to obtain taurine ammonium salt, and acidating and refining to obtain the taurine. The reaction steps of the technical scheme are less, the taurine ammonium salt can be obtained just by one-step reaction between the oxirane and the ammonium sulfite, the crude taurine can be obtained by acidating, and the taurine is obtained by refining, therefore, the synthesis method has simple process and can embody the economical efficiency and the cleaning production.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a method for synthesizing taurine. Background technique [0002] Taurine, also known as taurine, is a sulfur-containing non-protein amino acid with a chemical name of 2-aminoethanesulfonic acid (NH 2 CH 2 CH 2 SO 3 H), in recent years, along with the in-depth study to the physiological effect of taurine, nutritional value, its application is also more and more extensive, has important applications in aspects such as medicine, food, tensio-active agent, pH buffering agent. As a drug, taurine can be used for choleretic, liver protection, detoxification, anti-inflammatory, antipyretic, sedative, anticonvulsant, antiarrhythmia, treatment of cardiac insufficiency, regulation of osmotic pressure, lowering of blood pressure, treatment of arteriosclerosis, inhibition of central nervous system and maintenance of eyesight etc. At present, developed count...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/14C07C303/02
Inventor 陆昌元陆剑平王建峰温建华
Owner JIANGSU YUANYANG PHARMA
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