Use of oxyresveratrol

A technology of oxidized resveratrol and uses, applied in the directions of application, active ingredients of hydroxyl compounds, metabolic diseases, etc., can solve the problem of lack of hypoglycemic drugs, and achieve good inhibitory effect, relieve weight loss, and lower blood sugar levels.

Inactive Publication Date: 2010-06-02
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is a lack of hypoglycemic drugs prepared from monomeric natural compounds in the current drug market. Through research, the present invention finds that oxidized resveratrol is a monomeric compound with hypoglycemic effect

Method used

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  • Use of oxyresveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 In vitro inhibitory effect of oxidized resveratrol on α-glucosidase

[0018] drug:

[0019] α-glucosidase (EC 3.2.1.20, from yeast), Wako Pure Chemical Industries, Japan;

[0020] 4-nitrophenyl-α-D-glucopyranoside (PNPG), reduced glutathione, Shanghai Xibao Biotechnology Co., Ltd. Potassium dihydrogen phosphate and sodium hydroxide are analytically pure;

[0021] Oxygenated resveratrol, according to the literature (Fu Daxu, Chen Lei, Hou Aijun, Yao Qing, Zhang Wenwen. Research on the chemical constituents of black mulberry. Chinese herbal medicine, 2005, 36 (9): 1296-1299), the purity > 98% (HPLC).

[0022] Reagent:

[0023] Buffer: 0.1mol / l PH 7 phosphate buffer (potassium dihydrogen phosphate-sodium hydroxide);

[0024] Enzyme solution: Enzyme should be stored at -20°C. 0.01mol / l buffer solution (containing 0.2% BSA) was prepared into 0.2U / ml solution, and the enzyme solution was stored at -80°C;

[0025] Inhibitor: centrifuge the extract to get the s...

Embodiment 2

[0036] Example 2 Hypoglycemic effect experiment of oxidized resveratrol on alloxan diabetic mice

[0037] drug:

[0038] Alloxan, sigma company, ready-to-use, normal saline with a concentration of 1%, dose: 200mg / kg;

[0039] Glucose kit, Shanghai Rongsheng Biomedical Co., Ltd.;

[0040] Glyburide, 2.5mg / tablet, Shanghai Pharmaceutical (Group) Co., Ltd.;

[0041] Oxidized resveratrol, prepared in the laboratory according to the method of the literature (Fu Daxu, Chen Lei, Hou Aijun, Yao Qing, Zhang Wenyu. Research on the chemical constituents of black mulberry. Chinese herbal medicine, 2005, 36(9): 1296-1299), the purity> 98 % (HPLC).

[0042] animal:

[0043] Kunming mice, weighing 22-25g, Shanghai Slack Experimental Animal Co., Ltd.

[0044] Experimental method and results:

[0045] Ten normal male Kunming mice (22-25g) were randomly selected as the normal group, and the remaining mice were fasted for 16 hours, injected intraperitoneally with 200 mg / kg of alloxan, fed ...

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PUM

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Abstract

The invention relates to the use of oxyresveratrol in the preparation of medicaments, foods or health-care products capable of inhibiting the activity of alpha-glucosidase, the use of the oxyresveratrol in the preparation of hypoglycaemic medicaments, foods or health-care products, and the use of the oxyresveratrol in the preparation of medicaments, foods or health-care products for treating and preventing diabetes and complications of the diabetes. Therefore, in the invention, the oxyresveratrol can be used in the preparation of the medicaments, foods or health-care products capable of inhibiting the activity of the alpha-glucosidase, the preparation of the hypoglycaemic medicaments, foods or health-care products and the medicaments, foods or health-care products for treating and preventing diabetes and complications of the diabetes, thereby bringing good news for diabetics.

Description

technical field [0001] The present invention relates to the technical field of application of compounds, in particular to the technical field of application of stilbene compounds, and specifically refers to the application of oxidized resveratrol. Background technique [0002] Diabetes mellitus (DM) is a syndrome characterized by persistent high blood sugar. It is mainly due to the disorder of glucose metabolism caused by the relative or absolute deficiency of insulin in the body. In recent years, the incidence of diabetes has been increasing year by year, and it has become the third serious chronic disease after tumors and cardiovascular and cerebrovascular diseases. If diabetic patients do not take hypoglycemic treatment in time, it can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels and heart, and eventually blindness, lower limb gangrene, uremia, stroke or myocardial infarction. [0003] Except for insulin, most of the h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P3/10A23L1/30A23L33/105
Inventor 卢艳花王菡菁
Owner EAST CHINA UNIV OF SCI & TECH
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