Method for continuously extracting and separating 1-deoxynojirimycin (DNJ) and flavone from folium mori
A technology of deoxynojirimycin and mulberry leaves, applied to medical preparations containing active ingredients, pharmaceutical formulas, plant/algae/fungus/moss ingredients, etc., can solve problems such as difficult to remove, low active ingredients, easy to lose, etc. Achieve the effects of reducing viscosity and hygroscopicity, maintaining biological activity, and improving product quality
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Embodiment 1
[0027] The method for producing the mulberry leaf extract of the present invention has the following steps:
[0028] (a) Weigh 20Kg of mulberry leaf powder and place it in an extraction tank, add 160L of 60% ethanol, stir for 2h at 60°C, and filter with a centrifuge to obtain the filtrate;
[0029] (b) Add 160L of 60% ethanol to the filter residue, repeat the extraction once and filter according to the above conditions, combine the filtrates obtained twice, concentrate under reduced pressure at 70°C with a vacuum concentration tank, and recover ethanol;
[0030] (c) Dilute the concentrated solution to 100L with water, adjust the pH to 3 with hydrochloric acid, heat it to 55°C and keep it warm, add 4L of ZTC1+1 flocculant A component (1%) while stirring, and stir once every half hour; 2 hours Finally, add 2L of ZTC1+1 flocculant B component (1% viscose, prepared with 1% acetic acid), stir evenly, and stir again after half an hour, stop the heat preservation, and let stand overn...
Embodiment 2
[0036] The method for producing the mulberry leaf extract of the present invention has the following steps:
[0037] (a) Weigh 10Kg of mulberry leaf powder and place it in an extraction tank, add 400L of 40% ethanol, stir for 1h at 70°C, and filter with a centrifuge to obtain the filtrate;
[0038] (b) Add 40% ethanol to the filter residue, repeat the extraction once and filter according to the above conditions, combine the filtrate obtained twice, concentrate in a vacuum at 70° C. in a vacuum concentration tank, and recover ethanol;
[0039] (c) Dilute the concentrated solution to 60L with water, adjust the pH to 5 with hydrochloric acid, add 5L of 1% chitin solution, stir evenly, and let stand overnight;
[0040] (d) Press filtration to remove the precipitate, and the filtrate is pumped into 2 Dowex-50 cationic resin columns (D×H=10cm×100cm) connected in series, and then flows through 1 HPD-400 macroporous resin column (D ×H=10cm×60cm);
[0041] (e) After the filtrate is a...
Embodiment 3
[0045] The method for producing the mulberry leaf extract of the present invention has the following steps:
[0046] (a) Weigh 20Kg of mulberry leaf powder, place it in an extraction tank, add 400L of 80% ethanol, stir for 2h at 50°C, and filter with a centrifuge to obtain the filtrate;
[0047] (b) Add 200L of 80% ethanol to the filter residue, repeat the extraction once and filter according to the above conditions, combine the filtrates obtained twice, concentrate in a vacuum at 50° C. in a vacuum concentration tank, and recover ethanol;
[0048] (c) Dilute the concentrated solution with water to 100L, adjust the pH to 5 with acetic acid, heat it to 55°C and keep it warm, add 4L of ZTC1+1 flocculant A component (1%) while stirring, and stir once every half hour; 2 hours Finally, add 2L of ZTC1+1 flocculant B component (1% viscose, prepared with 1% acetic acid), stir evenly, and stir again after half an hour, stop the heat preservation, and let stand overnight;
[0049] (d) ...
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